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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Prediction of intravenous immunoglobulin resistance in Kawasaki disease in children

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World Journal of Pediatrics 2020年第6期16卷 607-613页

作者： Shu Wu Ying Liao Yan Sun Chun-Yu Zhang Qing-You Zhang Hui Yan Jian-Guang Qi Xue-Qin Liu Yong-Hong Chen Yu-Li Wang Xue-Ying Li Hong-Fang Jin Jun-Bao Du Department of Pediatrics Peking University First Hospital.No.1 Xi’an Men StreetXicheng DistrictBeijingChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education.BeijingChina

Background We aimed to explore predictive measures for intravenous immunoglobulin(IVIG)resistance in children with Kawasaki disease(KD).Methods Patients diagnosed with KD were enrolled in this *** analysis and multiple logistic regression were utilized to analyze the clinical features and laboratory results prior to IVIG-treatment of the two *** predictors of IVIG resistance were analyzed,and a predictive model for KD children with IVIG resistance was *** A total of 277 children with KD,180 boys and 97 girls,aged 2-128(median 23)months,were enrolled in the *** with the IVIG-responsive group,the IVIG-resistant group had higher levels of the peripheral neutrophil count,mean platelet volume,mean platelet volume-to-lymphocyte ratio and C-reactive protein,and total serum bilirubin,but lower levels of peripheral lymphocyte count,serum albumin and serum ***(in months),peripheral neutrophil count,lymphocyte count and mean platelet volume and serum albumin were independent indicators for IVIG resistance by multivariate logistic regression analysis.A logistic regression model and a scoring system were set up,where cut-off values of—0.46 and 6.5 points yielded sensitivities of 83.9%and 77.4%,and specificities of 74.8%and 61.0%,*** areas under the curve(AUC)were 0.808 in the logistic regression model,and 0.750 in the scoring *** Our model for predicting IVIG-resistant children with KD,involving age(months),peripheral neutrophil count,lymphocyte count and mean platelet volume and serum albumin prior to IVIG-treatment,is helpful for clinical prediction of children with IVIG-resistant KD.

关键词： intravenous immunoglobulin Kawasaki disease Resistance Prediction

intravenous immunoglobulin Treatment of Recurrent Miscarriage:an Update of Placebo-controlled Trials

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Journal of Reproduction and Contraception 2002年第3期13卷 177-186页

作者： ChristiansenOleB PedersenBjΦrn FertilityClinic4071 RigshospitaletCopenhagenDenmark DepartmentofObstetricsandGynaecology AalborgHospitalDenmark

Background Immunological disturbances which may be treated with intravenous immunoglobulin (IvIg) play a significant role in the majority of patients with recurrent miscarriage (RM). The present study aimed to review the current knowledge about IvIg treatment in RM primarily based on results from published placebo controlled trials. Seven placebo controlled trials were identified comprising a total of 343 patients. The background variables, the treatment protocols and the results were extremely different between the trials. Among the patients with secondary RM, a meta analysis showed that the pooled odds ratio for live birth among IvIg treated women compared with women infused with placebo was 1.69 (95 % CI = 0.72～3.96, not significant). IvIg also seemed to be efficacious in patients with repeated second trimester intrauterine fetal deaths. A new big placebo controlled trial should be conducted which focus on RM patients with secondary RM or recurrent second trimester fetal deaths. Sufficient IvIg doses should be given with optimal time intervals.

关键词： intravenous immunoglobulin recurrent miscarriage

A Systematic Review Incorporating Meta-Analysis on the Effectiveness of intravenous immunoglobulin Versus Corticosteroids in the Treatment of Pediatric Myocarditis

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Journal of Clinical and Nursing Research 2022年第3期6卷 14-23页

作者： Ahmed Mahmoud Abdelhaleem Ali Mohamed EA Abdelrahim Department of Pharmaceutics and Industrial Pharmacy College of PharmacyTaif University P.O.Box 11099 Taifi 21944Saudi Arabia Department of Clinical Pharmacy Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Background:Concerns have been raised about the efficacy of intravenous immunoglobulin and corticosteroids in pediatric myocarditis;however,the relationship between the risk and efficacy of these two therapies in children with myocarditis ***:A systematic review on seventeen studies was conducted in July 2020,which included 1,960 subjects at the baseline,with 788 receiving intravenous immunoglobulin and 142 receiving *** mean difference(MD)or odds ratio(OR)with 95%confidence intervals(Cis)was calculated to assess the prognostic role of both treatments using dichotomous and continuous methods with random or fixed-effect ***:The use of intravenous immunoglobulin was significantly associated with a lower mortality rate or heart transplantation in children with myocarditis(OR,0.55;95%CI,0.40-0.77,^intravenous immunoglobulin was not significantly related to improving left ventricular ejection in children with myocarditis(OR,2.30;95% CI,-9.65-14.25,p=0.71)and so were corticosteroids(MD,5.17;95% CI,-0.26-10.60,p=0.06).Conclusion:The use of intravenous immunoglobulin might have an independent risk relationship with a lower mortality rate or heart transplantation and is recommended in children with myocarditis to prevent complications.

关键词： intravenous immunoglobulin Corticosteroids Pediatric myocarditis Left ventricular ejection fraction Mortality rate Heart transplantation

Adverse events of intravenous immunoglobulin infusions:a three-year retrospective study in China

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Journal of Chinese Pharmaceutical Sciences 2019年第1期28卷 56-61页

作者： Shurong Shao Wei Guo Pharmaceutical department Ningbo Women&Children’s HospitalNingbo 315012China Molecular Neuropharmacology Laboratory School of Optometry and Ophthalmology and Eye HospitalWenzhou Medical UniversityWenzhou 325035China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of HealthChina and Zhejiang Provincial Key Laboratory of Ophthalmology and OptometryWenzhou 325035China

intravenous immunoglobulin(IVIG) is biological product, which is extensively used in pediatric patients, with high adverse effects on children among different brand preparations. In the present study, we aimed to describe the adverse events of pediatric patients given IVIG infusions in China. Data were collected from all patients receiving IVIG infusion at the largest children’s hospital in Ningbo of China form January 2015 to December 2017. Descriptive statistics was used. A total of 2100 patients received IVIG infusion. All the patients who experienced adverse reactions were children(0.48%), with the highest frequency of infusion among those age 1 to 3 years old(40%). Among 10 infusions with adverse reactions, the most common indication was Kawasaki disease(40%) followed by severe pneumonia(30%). Rash was the most common adverse event(80%), followed by chest pain & cough(50%) and cyanosis(40%). Adverse events were observed to occur most frequently within 30 min from onset of infusion. Most of the reactions occurred with the large dose and the indications of used for. Since the hospital changed the brand, the incidence of adverse reactions was decreased from 1.39% to 0.13%. In this study, 0.48% of pediatric patients given IVIG infusions experienced adverse events. Anaphylactoid reaction was the most common manifestation. Symptoms occurred within 30 min from onset of infusion, which were affected by the dose, the value of lgE, the indications and the different brands.

关键词： intravenous immunoglobulin Adverse reactions Children Retrospective study

Role of intravenous immunoglobulin in suspected or proven neonatal sepsis

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东南大学学报（医学版） 2013年第5期32卷 621-625页

作者： GAUTAM M K JIANG Li School of Medicine Southeast University Department of Pediatrics Zhongda HospitalSoutheast University

Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment,incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defence mechanisms. Though not approved by Food and Drug Administration(FDA) U. S. A,off label use of intravenous immunoglobulin as prophylactic or adjuvant agent in suspected or proven neonatal infections continues in many countries. In a recent large multicenter clinical trial by International Neonatal Immunotherapy Study(INIS) group, the use of polyvalent IgG immune globulin was not associated with significant differences in the risk of major complications or other adverse outcomes in neonates with suspected or proven sepsis. Hence,use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population,given the minimal benefit as demonstrated by many individual studies and by meta-analysis is not justified.

关键词： neonatal sepsis intravenous immunoglobulin review article

Haemolytic Anaemia Following High Dose intravenous immunoglobulin Treatment for Epidermolysis Bullosa Acquisita

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Pharmacology & Pharmacy 2016年第1期7卷 25-28页

作者： Sarah Madeline Brown Philip Jeremy Hampton Department of Dermatology The Newcastle upon Tyne Hospitals NHS Foundation Trust Royal Victoria Infirmary Newcastle UK

Background: Epidermolysis bullosa aquisita (EBA) is a severe acquired blistering skin disease that is often resistant to prednisolone but can respond well to intravenous immunoglobulin infusion (IVIg). Main Observations: We describe the case of a 35 years old male patient with EBA who developed clinically significant haemolytic anaemia with a drop in Hb from 15.3 g/dL to a nadir of 8.4 g/dL within 5 days post IVIg infusion. The patient was blood group A and the IVIg batch was found to have a high titre of anti-A immunoglobulin. Conclusions: IVIg is an effective treatment for EBA. Haemolysis associated with IVIg has not previously been reported in the dermatology literature but review of data from other specialties shows that the problem is well recognised. Dermatologists using IVIg should be aware of this potential complication and patients should be consented appropriately and warned about this potential side effect.

关键词： Haemolytic Anaemia Haemolysis intravenous immunoglobulin Epidermolysis Bullosa Aquisita EBA

An effective initial polytherapy for children with West syndrome

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Neural Regeneration Research 2013年第17期8卷 1623-1630页

作者： Feiyong Jia Huiyi Jiang Lin Du Ning Li Ji Sun Chunbo Niu Department of Pediatorehabilitation Second Part of First Hospital Jilin University Department of Pathology China-Japan Union Hospital of Jilin University

Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy, seizures recur in 33% of patients who initially respond to adrenocorticotropic hormone monotherapy, and side effects are relatively common during adrenocorticotropic hormone treatment. Topiramate, vitamin B6, and immunoglobulin are effective in some children with infantile spasms. In the present study, we hypothesized that combined therapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin would effectively treat infantile spasms and have mild adverse effects. Thus, 51 children newly diagnosed with West syndrome including infantile spasms were enrolled and underwent polytherapy with the four drugs. Electroencephalographic hypsarrhythmia was significantly improved in a majority of patients, and these patients were seizure-free, had mild side effects, and low recurrence rates. The overall rates of effective treatment and loss of seizures were significantly higher in cryptogenic children compared with symptomatic children. The mean time to loss of seizures in cryptogenic children was significantly shorter than in symptomatic patients. These findings indicate that initial polytherapy with adrenocorticotropic hormone, topiramate, vitamin Be, and immunoglobulin effectively improves the prognosis of infantile spasms, and its effects were superior in cryptogenic children to symptomatic children.

关键词： neural regeneration brain injury West syndrome spasm etiology polytherapy adrenocorticotropichormone topiramate vitamin B6 intravenous immunoglobulin seizure-free electroencephalograph neuroregeneration

Treatment of multisystem inflammatory syndrome in children

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World Journal of Pediatrics 2024年第4期20卷 325-339页

作者： Tong Tong Yi-Hua Jin Min Wang Fang-Qi Gong Department of Cardiology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNo.3333 Binsheng RoadHangzhou 310052China

Background Multisystem inflammatory syndrome in children(MIS-C),a relatively uncommon but severe pediatric complication,is associated with coronavirus disease 2019(COVID-19).A variety of treatment approaches,including intravenous immunoglobulins(IVIGs),glucocorticoids(GCs)and biologic agents,such as anakinra and infliximab,have been described for the management of COVID-19-related *** therapy is also ***,a well-developed treatment system has not been established,and many issues remain *** recently published articles related to the treatment of MIS-C have been ***,in this review,we identified relevant articles published recently and summarized the treatment of MIS-C more comprehensively and *** sources We reviewed the literature on the treatment of MIS-C through 20 September *** PubMed/Medline,Web of Science,EMBASE,and Cochrane Library databases were searched with the combination of the terms"multisystem inflammatory syndrome","MIS-C","PIMS-TS","therapy","treatment","drug","IVIG","GCs","intravenous immunoglobulin","corticosteroids","biological agent",and"aspirin".Results The severity of MIS-C varies,and different treatment schemes should be used according to the specific *** research and data collection are vital to better understand the pathophysiology and optimal management of *** MIS-Cis a disease involving multiple systems and has great *** the accumulation of additional experience,we have garnered fresh insights into its treatment ***,there remains a critical need for greater standardization in treatment protocols,alongside the pressing necessity for more robust and meticulously conducted studies to deepen our understanding of these protocols.

关键词： Coronavirus disease 2019-Corticosteroids intravenous immunoglobulin Multisystem inflammatory syndrome in children-Treatment

Current status and prospects of primary immunodeficiency diseases in Asia

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Genes & Diseases 2020年第1期7卷 3-11页

作者： Rakesh Kumar Pilania Himanshi Chaudhary Ankur Kumar Jindal Amit Rawat Surjit Singh Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarh160012India

Primary Immunodeficiency Diseases(PIDs)are increasingly being reported across the *** advances have been made in the diagnostic and therapeutic research related to *** increasing awareness,the field of PIDs has rapidly evolved in Asia as *** this review,we summarize the progress that has been made in the field of PIDs in Asian countries;major limitations and challenges faced by the clinicians working in this field in Asia;difference in spectrum of PIDs in Asia from rest of the World;current state of diagnostic and treatment facilities available in various countries in Asia and the future prospects of these diseases in the continent.

关键词： Asia Genetic diagnosis Hematopoietic stem cell transplant intravenous immunoglobulin Primary immunodeficiency diseases