Prediction of intravenous immunoglobulin resistance in Kawasaki disease in children
作者机构：Department of PediatricsPeking University First Hospital.No.1 Xi’an Men StreetXicheng DistrictBeijingChina Key Laboratory of Molecular Cardiovascular SciencesMinistry of Education.BeijingChina
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2020年第16卷第6期
页 面：607-613页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：The work was supported by Peking University Clinical Scientist Program(BMU2019LCKXJ001) and Fundamental Research for the Central Universities
主 题：Intravenous immunoglobulin Kawasaki disease Resistance Prediction
摘 要：Background We aimed to explore predictive measures for intravenous immunoglobulin(IVIG)resistance in children with Kawasaki disease(KD).Methods Patients diagnosed with KD were enrolled in this *** analysis and multiple logistic regression were utilized to analyze the clinical features and laboratory results prior to IVIG-treatment of the two *** predictors of IVIG resistance were analyzed,and a predictive model for KD children with IVIG resistance was *** A total of 277 children with KD,180 boys and 97 girls,aged 2-128(median 23)months,were enrolled in the *** with the IVIG-responsive group,the IVIG-resistant group had higher levels of the peripheral neutrophil count,mean platelet volume,mean platelet volume-to-lymphocyte ratio and C-reactive protein,and total serum bilirubin,but lower levels of peripheral lymphocyte count,serum albumin and serum ***(in months),peripheral neutrophil count,lymphocyte count and mean platelet volume and serum albumin were independent indicators for IVIG resistance by multivariate logistic regression analysis.A logistic regression model and a scoring system were set up,where cut-off values of—0.46 and 6.5 points yielded sensitivities of 83.9%and 77.4%,and specificities of 74.8%and 61.0%,*** areas under the curve(AUC)were 0.808 in the logistic regression model,and 0.750 in the scoring *** Our model for predicting IVIG-resistant children with KD,involving age(months),peripheral neutrophil count,lymphocyte count and mean platelet volume and serum albumin prior to IVIG-treatment,is helpful for clinical prediction of children with IVIG-resistant KD.
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