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sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection

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Asian Journal of Andrology 2021年第1期23卷 59-63页

作者： Hong-Liang Zhang Lian-Ming Zhao Jia-Ming Mao De-Feng Liu Wen-Hao Tang Hao-Cheng Lin Li Zhang Ying Lian Kai Hong Hui Jiang Department of Urology Peking University Third HospitalBeijing 100191China Department of Reproductive Medicine Center Peking University Third HospitalBeijing 100191China Department of Andrology Peking University Third HospitalBeijing 100191China Department of Human sperm Bank Peking University Third HospitalBeijing 100191China

The aim of our study was to compare the sperm retrieval rates(SRRs)and clinical outcomes of patients with different causes of azoospermia who underwent microdissection testicular sperm extraction-intracytoplasmic sperm injection(micro-TESE-ICSI).We conducted a retrospective study at the Reproductive Medicine Center of Peking University Third Hospital in Beijing,China,from January 2014 to December *** study examined 769 patients with nonobstructive azoospermia who underwent 347 cycles of *** with azoospermia were classified into Group A(Klinefelter syndrome,n=284,125 cycles),Group B(azoospermia Y chromosome factor c[AZFc]microdeletion,n=91,64 cycles),Group C(cryptorchidism,n=52,39 cycles),Group D(previous mumps and bilateral orchitis,n=23,23 cycles),and Group E(idiopathic azoospermia,n=319,96 cycles).Clinical characteristics,SRR,embryonic development,and pregnancy outcomes of the patients were compared between all *** in Group D had the highest and most successful *** average SRR for all patients was 46.0%.The rates of clinical pregnancy,implantation,and live birth in Group D were 78.3%,65.0%,and 74.0%,respectively,which were higher than those in all other groups(P0.05).Patients with orchitis had the highest SRR and best clinical *** AZFc microdeletion patients had a higher SRR,their clinical outcomes were worse.

关键词： azoospermia intracytoplasmic sperm injection microdissection testicular sperm extraction pregnancy outcomes sperm retrieval rate

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Clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection with fresh or cryopreserved sperm in patients with nonobstructive azoospermia

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Asian Journal of Andrology 2021年第2期23卷 211-214页

作者： Hong-Liang Zhang Jia-Ming Mao De-Feng Liu Lian-Ming Zhao Wen-Hao Tang Kai Hong Li Zhang Ying Lian Hao-Cheng Lin Hui Jiang Department of Urology Peking University Third HospitalBeijing 100191China Department of Reproductive Medicine Center Peking University Third HospitalBeijing 100191China Department of Human sperm Bank Peking University Third HospitalBeijing 100191China

We performed this study to evaluate the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection(micro-TESE-ICSI)treatment that used fresh or cryopreserved sperm in patients with nonobstructive azoospermia(NOA).A total of 338 NOA patients with 344 consecutive cycles received treatment in the reproductive medicine center of Peking University Third Hospital in Beijing,China,from January 2014 to December *** oocytes and fresh sperm were used in 222 patients with 234 cycles(Group A).Fresh oocytes and cryopreserved sperm were used in 116 patients with 110 cycles(Group B).We compared patient characteristics,embryonic development,and pregnancy outcomes between Groups A and *** was no statistical difference in the patient characteristics,and no differences were observed with fertilization or quality embryo rates between Groups A and *** rates of clinical pregnancy and live birth were both higher for Group A than those for Group B(both Psperm appears to produce better ICSI outcomes than cryopreserved testicular sperm in patients with NOA.

关键词： azoospermia cryopreservation intracytoplasmic sperm injection microdissection testicular sperm extraction pregnancy outcomes

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Modified strict sperm morphology threshold aids in the clinical selection of conventional in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)

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Asian Journal of Andrology 2022年第1期24卷 62-66页

作者： Yong Zhu Feng Zhang Hua Cheng Xiao-Xi Sun Feng Jiang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Ji Ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China

For infertility treatment,the selection of in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI)is decided by multiplying indicators(including fallopian tube factors,semen count,and semen motility),except for sperm *** this study,we conducted a retrospective analysis,from implantation to birth,over a period of 5 years.A total of 1873 couples with primary or secondary fallopian tube factors and an increased defective sperm morphology rate(DSMR)were divided into different groups to receive IVF or ICSI *** comparing the outcomes,we found that the F1 group(DSMR98%,IVF group 3;P98%,ICSI group 3)had higher cleavage rate(Psperm morphology should also be considered when selecting IVF or ICSI combined with other semen parameters before the first assisted reproductive technologies(ART)cycle,especially for males with severe sperm defects.

关键词： clinical outcome in vitro fertilization intracytoplasmic sperm injection sperm morphology

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A nomogram predicting clinical pregnancy in the first fresh embryo transfer for women undergoing in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI) treatments

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The Journal of Biomedical Research 2019年第6期33卷 422-429页

作者： Fang Wu Feng Liu Yichun Guan Jiangbo Du Jichun Tan Hong Lv Qun Lu Shiyao Tao Lei Huang Kun Zhou Yankai Xia Xinru Wang Hongbing Shen Xiufeng Ling Feiyang Diao Zhibin Hu Guangfu Jin State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Reproduction Henan Women and Children Health HospitalHenan 450052China Department of Reproduction Shengjing Hospital of China Medical UniversityShenyangLiaoning 110011China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Reproduction the Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical UniversityNanjingJiangsu 210004China Department of Reproduction the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The extent to which factors affect the probability of clinical pregnancy in the first fresh embryo transfer after assisted conception is *** order to examine the predictors of clinical pregnancy,a retrospective cohort study was launched between January 1,2013 and December 31,2016 in four infertility clinics including 19837 in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI)fresh cycles with known outcomes and relevant records.A multivariable logistic regression was used to select the most significant predictors in the final nomogram for predicting clinical ***,the model was validated by an independent validation set and the performance of the model was evaluated by the receiver operating characteristic(ROC)curves along with the area under the ROC curve(AUC)and calibration *** a training set including 17854 participants,we identified that female age,tubal factor,number of embryos transferred,endometrial thickness and number of good-quality embryos were independent predictors for clinical *** developed a nomogram using these five factors and the predictive ability was 0.66 for AUC(95%CI=0.64−0.68),which was independently validated in the validation set(AUC=0.66,95%CI=0.65−0.68).Our results show that some specific factors can be used to provide infertile couples with an accurate assessment of clinical pregnancy following assisted conception and facilitate to guide couples and clinicians.

关键词： clinical pregnancy prediction model in vitro fertilization intracytoplasmic sperm injection nomogram

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Pregnancy outcome after intracytoplasmic sperm injection with strontium oocyte activation in a globozoospermic patient

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Asian Journal of Andrology 2012年第2期14卷 341-343页

作者： Xiao-Yu Yang Jing Wang Jia-Yin Liu Yan Gao Zuo-Min Zhou Jia-Hao Sha Wei Zhang Yu-Gui Cui Xiao-Qiao Qian State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineFirst Affiliated HospitalNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologyNanjing Medical universityNanjing 210029China Department of Urology First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Dear Editor, I am Dr Xiao-Yu Yang, from the Center of Clinical Reproductive Medicine in the First Affiliated Hospital at the NanJing Medical University, Nanjing, China. We present here a case report of a globo- zoospermic patient whose partner became pregnant after intracyto- plasmic sperm injection （ICSI） with assisted oocyte activation （AOA）.

关键词： strontium globozoospermic patient intracytoplasmic sperm injection

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Cumulative live birth rates of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in China

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The Journal of Biomedical Research 2020年第5期34卷 361-368,I0002-I0006页

作者： Lei Huang Qun Lu Jiangbo Du Hong Lv Shiyao Tao Shiyao Chen Xiuzhu Li Xiumei Han Kun Zhou Bo Xu Xiaoyu Liu Hongxia Ma Yankai Xia Guangfu Jin Hongbing Shen Xiufeng Ling Zhibin Hu Jichun Tan Feiyang Diao State Key Laboratory of Reproductive Medicine School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Epidemiology School of Public HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Toxicology School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Reproduction the Affiliated Nanjing Maternity and Child Health Hospital of Nanjing Medical UniversityNanjingJiangsu 210004China Center of Reproductive Medicine Department of Obstetrics and GynecologyShengjing Hospital of China Medical UniversityShenyangLiaoning 110022China Department of Reproduction the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

There were few studies of cumulative live birth rates(CLBRs) based on multicenter reproductive clinical data from the general Chinese *** we report a retrospective cohort study,including 14 311 women with17 315 cycles,in three reproductive centers to evaluate two estimated parameters of CLBRs with multiple transfer cycles of in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI) in a Chinese *** found that CLBRs were related to female age and endometrial *** the fourth transfer cycle,the conservative and optimal estimates of CLBRs were 52.95% and 77.30% in women under 30 years of age,and 18.17% and26.51% in those 37 years of age or older,*** two estimates were 44.70% and 63.15% in women with endometrial thickness more than 7 mm,and 32.05% and 46.18% in those with less than 7 mm,*** addition,body mass index(BMI),duration of infertility,and infertility diagnoses may also be related to CLBRs on certain *** findings from this study on CLBRs after multiple transfer cycles of IVF/ICSI treatment on different conditions in the Chinese population should be beneficial to both infertile couples and clinicians.

关键词： cumulative live birth rate in vitro fertilization intracytoplasmic sperm injection

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Genetic and epigenetic risks of intracytoplasmic sperm injection method

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Asian Journal of Andrology 2006年第6期8卷 643-673页

作者： Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology loannina University School of Medicine loannina 45110 Greece Cytogenetics Unit Laboratory of General Biology Medical School University of loannina loannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan Department of Molecular Pharmacology Tottori University School of Medicine Yonago 683 Japan

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection （ICSI） procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent thatconsequences of the genetic abnormalities underlying male subfertility （or infertility） and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.

关键词： genetic risks epigenetic risks intracytoplasmic sperm injection testis male infertility

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Chinese Medical Journal 2021年第12期134卷 1405-1415页

作者： Rui Yang Zi-Ru Niu Li-Xue Chen Ping Liu Rong Li Jie Qiao Center for Reproductive Medicine Peking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Background:More and more scholars have called for the cumulative live birth rate(CLBR)of a complete ovarian stimulation cycle as a key indicator for assisted reproductive *** research aims to study the CLBR of the first ovarian hyperstimulation cycles and analyze the related prognosis factors that might affect the ***:Our retrospective study included first in vitro fertilization or intracytoplasmic sperm injection(IVF/ICSI)cycles performed between January 2013 to December 2014.A total of 17,978 couples of first ovarian hyperstimulation IVF/ICSI cycles were *** study was followed up for 4 years to observe the *** multivariable logistic regression model was used to analyze the prognosis factor,P value of<0.05 was considered statistically ***:The cumulative pregnancy rate was 58.14%(10,452/17,978),and the CLBR was 49.66%(8928/17,978).The female age was younger in the live birth group when compared with the non-live birth group(30.81±4.05 vs.33.09±5.13,P<0.001).The average duration of infertility was shorter than the non-live birth cohort(4.22±3.11 vs.5.06±4.08,P<0.001).The preliminary gonadotropin used and the total number of gonadotropin used were lower in the live birth group when compared with the non-live birth group(both P<0.001).Meanwhile,the number of oocytes retrieved and transferrable embryos were both significantly higher in the live birth group(15.35±7.98 vs.11.35±7.60,P<0.001;6.66±5.19 vs.3.62±3.51,P<0.001,respectively).Conclusions:The women's age,body mass index,duration of infertility years,infertility factors,controlled ovarian hyperstimulation protocol,the number of acquired oocytes,and number of transferrable embryos are the prognosis factors that significantly affected the CLBR.

关键词： Cumulative live birth rates IVF ICSI Controlled ovarian hyperstimulation In vitro fertilization intracytoplasmic sperm injection

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A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection

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Chinese Medical Journal 2012年第3期000卷 546-548页

作者： Lu Qun Chen Xi Li Yang Zhang Xiao-hong Liang Rong Zhao Yong-ping Wei Li-hui Shen Huan Peking Univ Peoples Hosp Reprod Med Ctr Beijing 100044 Peoples R China Peking Univ Peoples Hosp Dept Obstet & Gynecol Beijing 100044 Peoples R China Minist Educ Key Lab Assisted Reprod Beijing 100191 Peoples R China Shandong Univ Shandong Prov Hosp Ctr Reprod Med Jinan 250021 Shandong Peoples R China

Total or near-total fertilization failure after intracytoplasmic sperm injection （ICSl） is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 （A23187） activation on one-day-old unfertilized oocytes in a patient whose husband suffered oligoasthenoteratozoospermia, and who had experienced repeated near-total fertilization failure after ICSI. In the second ICSI cycle, only one oocyte was fertilized while nine were unfertilized. Oocyte activation with A23187 were performed on the one-day-old unfertilized oocytes after ICSI and resulted in fertilization and embryo transfer. A clinical pregnancy was achieved and a healthy baby was born. To our knowledge, this is the first reported case of a healthy birth after oocyte activation on the one-day-old unfertilized oocyte. This indicates that ＂rescue oocyte activation＂ on one-day-old unfertilized oocytes after ICSI may be helpful for preventing total or near-total fertilization failure after ICSI.

关键词： intracytoplasmic sperm injection fertilization failure oocyte activation calcium ionophore A23187

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Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome

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Asian Journal of Andrology 2005年第2期7卷 217-220,页

作者： Takuya Akashi Hideki Fuse Yasuo Kojima Mikiko Hayashi Sachiko Honda Department of Urology Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan Department of Obsterics and Gynecology Toyama Prefectural Central HospitalToyamaJapan Toyama Institute of Health ToyamaJapan

Aim:To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) ***:A 35-year- old man with a normal appearance consulted our hospital because of sterility over a 5-year *** analysis showed low-incidence mosaic Klinefelter's *** FISH,96 % hyperploidy of the lymphocytes was *** examined the sex chromosome of the ejaculated *** FISH,we examined 200 ejacu- lated spermatozoa and no hyperploidy was ***:The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol,following late luteal phase pituitary down *** culminated in the retrieval of seven oocytes,six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby ***:We report a male patient with low- incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI,leading to the successful pregnancy of his wife and the birth of a healthy baby girl.

关键词： Klinefelter's syndrome intracytoplasmic sperm injection fluorescence in situ hybridization

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