Analysis of related factors affecting cumulative live birth rates of the first ovarian hyperstimulation in vitro fertilization or intracytoplasmic sperm injection cycle: a population-based study from 17,978 women in China

作     者：Rui Yang Zi-Ru Niu Li-Xue Chen Ping Liu Rong Li Jie Qiao Yang Rui;Niu Zi-Ru;Chen Li-Xue;Liu Ping;Li Rong;Qiao Jie

作者机构：Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and GynecologyBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University)Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing 100191China Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第12期

页      面：1405-1415页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071008[理学-发育生物学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grants from the National Key Research and Development Program of China(No.2018YFC1002106) the National Science Foundation for Young Scientists of China(No.81801447) 

主　　题：Cumulative live birth rates IVF ICSI Controlled ovarian hyperstimulation In vitro fertilization Intracytoplasmic sperm injection 

摘      要：Background:More and more scholars have called for the cumulative live birth rate(CLBR)of a complete ovarian stimulation cycle as a key indicator for assisted reproductive *** research aims to study the CLBR of the first ovarian hyperstimulation cycles and analyze the related prognosis factors that might affect the ***:Our retrospective study included first in vitro fertilization or intracytoplasmic sperm injection(IVF/ICSI)cycles performed between January 2013 to December 2014.A total of 17,978 couples of first ovarian hyperstimulation IVF/ICSI cycles were *** study was followed up for 4 years to observe the *** multivariable logistic regression model was used to analyze the prognosis factor,P value of0.05 was considered statistically ***:The cumulative pregnancy rate was 58.14%(10,452/17,978),and the CLBR was 49.66%(8928/17,978).The female age was younger in the live birth group when compared with the non-live birth group(30.81±4.05 vs.33.09±5.13,P0.001).The average duration of infertility was shorter than the non-live birth cohort(4.22±3.11 vs.5.06±4.08,P0.001).The preliminary gonadotropin used and the total number of gonadotropin used were lower in the live birth group when compared with the non-live birth group(both P0.001).Meanwhile,the number of oocytes retrieved and transferrable embryos were both significantly higher in the live birth group(15.35±7.98 vs.11.35±7.60,P0.001;6.66±5.19 vs.3.62±3.51,P0.001,respectively).Conclusions:The women s age,body mass index,duration of infertility years,infertility factors,controlled ovarian hyperstimulation protocol,the number of acquired oocytes,and number of transferrable embryos are the prognosis factors that significantly affected the CLBR.