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Association of interpregnancy interval and risk of adverse pregnancy outcomes in woman by different previous gestational ages

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Chinese Medical Journal 2024年第1期137卷 87-96页

作者： Peiran Chen Yi Mu Zheng Liu Yanping Wang Xiaohong Li Li Dai Qi Li Mingrong Li Yanxia Xie Juan Liang Jun Zhu National Office for Maternal and Child Health Surveillance of China West China Second University HospitalSichuan UniversityChengduSichuan 610066China Department of Obstetrics West China Second University HospitalSichuan UniversityChengduSichuan 610066China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengduSichuan 610066China

Background:With an increasing proportion of multiparas,proper interpregnancy intervals(IPIs)are urgently ***,the association between IPIs and adverse perinatal outcomes has always been *** study aimed to explore the association between IPIs and adverse outcomes in different fertility policy periods and for different previous gestational ***:We used individual data from China’s National Maternal Near Miss Surveillance System between 2014 and *** Poisson models with restricted cubic splines were *** adverse outcome was analyzed separately in the overall model and stratified *** stratified models included different categories of fertility policy periods(2014-2015,2016-2017,and 2018-2019)and infant gestational age in previous pregnancy(<28 weeks,28-36 weeks,and≥37 weeks).Results:There were 781,731 pregnancies enrolled in this study.A short IPI(≤6 months)was associated with an increased risk of preterm birth(OR[95%CI]:1.63[1.55,1.71]for vaginal delivery[VD]and 1.10[1.03,1.19]for cesarean section[CS]),low Apgar scores and small for gestational age(SGA),and a decreased risk of diabetes mellitus in pregnancy,preeclampsia or eclampsia,and gestational hypertension.A long IPI(≥60 months)was associated with an increased risk of preterm birth(OR[95%CI]:1.18[1.11,1.26]for VD and 1.39[1.32,1.47]for CS),placenta previa,postpartum hemorrhage,diabetes mellitus in pregnancy,preeclampsia or eclampsia,and gestational *** policy changes had little effect on the association of IPIs and adverse maternal and neonatal *** estimated risk of preterm birth,low Apgar scores,SGA,diabetes mellitus in pregnancy,and gestational hypertension was more profound among women with previous term births than among those with preterm births or pregnancy ***:For pregnant women with shorter or longer IPIs,more targeted health care measures during pregnancy should be formulated according to infant gestational age in

关键词： interpregnancy interval Fertility policy Gestational age Preterm birth Gestational hypertension Diabetes mellitus in pregnancy

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Interactions between long interpregnancy interval and advanced maternal age on neonatal outcomes

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World Journal of Pediatrics 2023年第12期19卷 1155-1161页

作者： Yan Ma Hua Fu Yang li Zheng‑Rong Bao Wen‑Bin Dong Xiao‑Ping Lei Division of Neonatology Department of PediatricsThe Affiliated Hospital of Southwest Medical UniversityXiaoping Lei8 Kangcheng RoadLuzhou 646000China Department of Perinatology The Afliated Hospital of Southwest Medical UniversityLuzhouChina Sichuan Clinical Research Center for Birth Defects LuzhouChina School of Pediatrics Southwest Medical UniversityLuzhouChina

Background After the implementation of the universal two-child policy in China,it was more frequent to have long interpregnancy intervals(IPIs)and advanced maternal ***,the interactions between long IPIs and advanced maternal age on neonatal outcomes are *** The study subjects of this historical cohort study were multiparas with singleton live births between October 1st,2015,and October 31st,*** was defned as the interval between delivery and conception of the subsequent *** regression models were used to calculate adjusted odds ratios(aORs)and 95%confdence intervals(CIs)of the risks of preterm birth(PTB),low birth weight(LBW),small for gestation age,and 1-min Apgar score≤7 in diferent IPI *** excess risk due to interaction(RERI)was used to evaluate the additive interaction between long IPIs and advanced maternal *** Compared with the 24≤IPI≤59 months group,the long IPI group(IPI≥60 months)was associated with a higher risk of PTB(aOR,1.27;95%CI:1.07–1.50),LBW(aOR,1.32;95%CI 1.08–1.61),and one-minute Apgar score≤7(aOR,1.46;95%CI 1.07–1.98).Negative additive interactions(all RERIs<0)existed between long IPIs and advanced maternal age for these neonatal ***,IPI<12 months was also associated with PTB(aOR,1.51;95%CI 1.13–2.01),LBW(aOR,1.50;95%CI 1.09–2.07),and 1-min Apgar score≤7(aOR,1.93;95%CI 1.23–3.04).Conclusions Both short and long IPIs are associated with an increased risk of adverse neonatal *** IPI should be recommended to women planning to become pregnant *** addition,better antenatal care might be taken to balance the inferiority of advanced maternal age and to improve neonatal outcomes.

关键词： Interaction interpregnancy interval Low birth weight Maternal age Preterm birth

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Long interpregnancy interval and adverse perinatal outcomes: a retrospective cohort study

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Science China(Life Sciences) 2020年第6期63卷 898-904页

作者： Jing Lin Han Liu Dan-Dan Wu Hong-Tao Hu Hui-Hui Wang Cheng-Liang Zhou Xin-Mei Liu Xiao-Jun Chen Jian-Zhong Sheng He-Feng Huang International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Institute of Embryo-Fetal Original Adult Disease Shanghai Key Laboratory for Reproductive MedicineSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Disease Shanghai 200030China Department of Pathology and Pathophysiology School of MedicineZhejiang UniversityHangzhou 310058China

We conducted a retrospective cohort study of 9,552 women experiencing their second delivery between 2014 and 2016 at the International Peace Maternity and Child Health Hospital to investigate the association between the interpregnancy interval(IPI)and adverse perinatal outcomes. With the 12–23-mon IPI as the reference category, logistic regression analyzes were used to examine associations between different IPIs(interval(CI) 1.32–2.35 and adjusted OR 2.03, 95% CI 1.53–2.67, respectively). These results indicate that a longer IPI is associated with a higher risk of adverse perinatal outcomes and an IPI of ≥120 mon appears to be independently associated with a higher risk of gestational diabetes mellitus and premature membrane rupture.

关键词： interpregnancy interval perinatal outcomes gestational diabetes mellitus premature membrane rupture

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Association between the Length of interpregnancy interval and Pregnancy Outcomes in Women with One Previous Caeserian Section Undergoing a Repeat Caeserian Delivery at Term at Pumwani Maternity Hospital between 2014 and 2018 a Cross-Sectional Study

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Open Journal of Obstetrics and Gynecology 2021年第2期11卷 80-87页

作者： Auma Adipo Diana Ondieki Omondi Ogutu Anne Pulei The University of Nairobi Nairobi Republic of Kenya

Caesarean sections constitute major surgery, and are associated with immediate maternal and perinatal risks with implications on future pregnancies. After a caesarean delivery, the World Health Organization (WHO) recommends an Inter-pregnancy interval (IPI) of at least 24 months to lower the risk of adverse maternal and perinatal outcomes in the subsequent pregnancy. However, whether the recommendation confers obstetric benefits is unclear as there’s paucity of data in low- and medium-income countries (LMIC). The objective was to determine the association between IPI length and maternal and neonatal outcomes in women with one previous caesarian section undergoing a repeat caesarian delivery at term in Pumwani Maternity Hospital between 1st January 2014 and 31st December 2018. A cross-sectional study was done where patients who had delivered via repeat caesarean section at term between 1st January 2014 and 31st December 2018 were evaluated. The files of 625 patients were retrieved and IPI was determined from the time interval between a previous caesarean section delivery and the beginning of the subsequent pregnancy, established from the date of the last normal menstrual period as recorded or extrapolated from an early trimester obstetric scan. The files were allotted to study groups as follows: = 170), 24

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