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interferon-gamma release assay is Not Appropriate for the Diagnosis of Active Tuberculosis in High-Burden Tuberculosis Settings： A Retrospective Multicenter Investigation

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Chinese Medical Journal 2018年第3期131卷 268-275页

作者： Wan-Li Kang Gui-Rong Wang Mei-Ying Wu Kun-Yun Yang Er-Tai A Shu-Cai Wu Shu-Jun Geng Zhi-Hui Li Ming-Wu Li Liang Li Shen-Jie Tang Epidemiology Research Department Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149 China Tuberculosis Clinical Laboratory Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149 China Department of Tuberculosis Souzhou 5th People's Hospital Souzhou Jiangsu 215007 China Department of Tuberculosis Hunan Chest Hospital Changsha Hunan 410013 China Department of Tuberculosis Chest Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang 830049 China Department of Tuberculosis Hebei Chest Hospital Shijiazhuang Hebei 050041 China Department of Tuberculosis Kunming 3rd People's Hospital Kunming Yunnan 650041 China Department of Tuberculosis Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149China

Background：interferon-gamma release assay （IGRA） has been used in latent tuberculosis （TB） infection and TB diagnosis,but the results from different high TB-endemic countries are *** aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB （PTB） in ***：We conducted a large-scale retrospective multicenter investigation to further evaluate the role of IGRA in the diagnosis of active PTB in high TB-epidemic populations and the factors affecting the performance of the *** patients who underwent valid *** assays from December 2012 to November 2015 in six large-scale specialized TB hospitals in China and met the study criteria were retrospectively *** were divided into three groups：Group 1,sputum culture-positive PTB patients,confirmed by positive Mycobacterium tuberculosis sputum culture;Group 2,sputum culture-negative PTB patients;and Group 3,non-TB respiratory *** medical records of all patients were ***-square tests and Fisher＇s exact test were used to compare categorical *** logistic analyses were performed to evaluate the relationship between the results of T-SPOT in TB patients and other ***：A total of 3082 patients for whom complete information was available were included in the investigation,including 905 sputum culture-positive PTB cases,914 sputum cultmre-negative PTB cases,and 1263 non-TB respiratory disease *** positive rate of *** was 93.3% in the culture-positive PTB group and 86.1% in the culture-negative PTB *** the non-PTB group,the positive rate of *** was 43.6%.The positive rate of *** in the culture-positive PTB group was significantly higher than that in the culture-negative PTB group （x2 =25.118,P 〈 0.01）,which in turn was significantly higher than that in the non-TB group （x2 =566.l 16,P 〈 0.01）.The overall results were as follows：sensitivity,89.7%;specificity,56.37%;positive predictive valu

关键词： Active Tuberculosis Diagnosis interferon-gamma release assay

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Early detection of Toxoplasma gondii-infected cats by interferon-gamma release assay(IGRA)

Early detection of Toxoplasma gondii-infected cats by interf...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Qing Yin Saeed El-Ashram Xianyong Liu Xun Suo State Key Laboratory for Agrobiotechnology China Agricultural University National Animal Protozoa Laboratory & College of Veterinary Medicine China Agricultural University Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture

Felines,the only definitive hosts that shed the environmentally-durable oocysts,are the key in the transmission of Toxoplasma gondii to all warm-blooded *** seroconvert as late as the third week and begin to shed oocysts as early as 3-8 days after being fed tissue *** detection of Toxoplasma-infected cats is crucial to evaluate Toxoplasma-contaminated environment and potential risks to public ***,it is fundamental for Toxoplasma infection ***-gamma release assay(IGRA) is a blood-based test assessing the presence of IFN-γ released by the T-lymphocytes directed against specific antigens,which is an ideal assay for early detection of Toxoplasma-infected ***,cats were orally infected with the tissue cysts and blood was collected for toxoplasmic antigen stimulation,and the released IFN-γ was measured by *** showed that Toxoplasma-infection was detected by IGRA as early as 4 days post-infection(dpi);while serum Toxoplasma IgM and IgG were detected by ELISA at 10 dpi and 14 dpi,*** findings demonstrated that IGRA-positive and ELISA-negative samples revealed an early Toxoplasma infection in cats,indicating a new strategy for the early diagnosis of Toxoplasma infection by combining IGRA and ***,IGRA could emerge as a reliable diagnostic tool for the exploration of cat toxoplasmosis prevalence and its potential risks to public health.

关键词： cat Toxoplasma gondii interferon-gamma release assay early detection

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interferon-gamma release assays as a tool for differential diagnosis of gastrointestinal tuberculosis

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World Journal of Clinical Cases 2024年第27期12卷 6015-6019页

作者： Tsvetelina Velikova Anita Aleksandrova Medical Faculty Sofia University Street Kliment OhridskiSofia 1407Bulgaria Department of Immunology Medical-diagnostic laboratory RamusSimitli 6000Bulgaria

In this editorial,we comment on an article published in a recent issue of the World Journal of Clinical *** is a pressing need for reliable tools for diagnosing tuberculosis(TB)of the gastrointestinal *** advancements in the diagnosis and treatment,TB remains a global health *** et al demon-strated that TB may mimic gastrointestinal conditions,such as gastric outlet obstruction,causing a delay in the ***,the latter complication is frequently observed during infections,including Helicobacter pylori,and rarely is related to TB,as in the presented *** line with this,we think that laboratory tests based on interferon-gamma release assays can be a helpful tool for diagnosing latent TB paced in the gastrointestinal *** strategies and approaches for diagnosing latent/active extra pulmonary TB are crucial for establishing the diagnosis early and enhancing treatment strategies to mitigate the global burden of TB.

关键词： Tuberculosis Gastrointestinal tuberculosis interferon-gamma release assay IGRA Primary gastroduodenal tuberculosis Gastric outlet obstruction Case report

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Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

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Infectious Diseases of Poverty 2017年第1期6卷 1074-1078页

作者： Lei Ji Yong-Liang Lou Zhong-Xiu Wu Jin-Qin Jiang Xing-Li Fan Li-Fang Wang Xiao-Xiang Liu Peng Du Jie Yan Ai-Hua Sun Department of Basic Medicine Hangzhou Medical CollegeHangzhou 310053ZhejiangPeople’s Republic of China School of Laboratory Medical Science and Life Science Wenzhou Medical UniversityWenzhou 325035ZhejiangPeople’s Republic of China Zhejiang Blood Center Hangzhou 310006ZhejiangPeople’s Republic of China Division of Basic Medical Microbiology State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesFirst Affiliated Hospital of Zhejiang UniversityHangzhou 310003ZhejiangPeople’s Republic of China Department of Medical Microbiology and Parasitology College of MedicineZhejiang UniversityHangzhou 310058ZhejiangPeople’s Republic of China

Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical *** research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary ***:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy *** samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s ***:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),*** was no statistically significant difference of its performance between these two sample sets(P>0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P>0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis.

关键词： interferon-gamma release assay Smear-negative pulmonary TB Extra-pulmonary TB

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Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors

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World Journal of Clinical Cases 2024年第33期12卷 6604-6607页

作者： Dan-Xiang Shen Yu-Wei Wang Zhi-Min Lin Di Jin Zhen-Hua Ying Chen Li Department of Internal Medicine Changxing Third People's HospitalHuzhou 313000Zhejiang ProvinceChina Department of Rheumatology and Immunology Jinzhou Medical University Graduate Training Base Zhejiang Provincial People's HospitalCenter for General Practice MedicineZhejiang Provincial People's HospitalHangzhou 310000Zhejiang ProvinceChina Department of Rheumatology Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Cultivation for Arthritis Diagnosis and TreatmentHangzhou 310000Zhejiang ProvinceChina Department of Cardiology Yidu Central Hospital of WeifangWeifang 261000Shandong ProvinceChina Third Affiliated Hospital Beijing University of Chinese MedicineBeijing 100020China Department of Rheumatology Weifang People's HospitalWeifang 261000Shandong ProvinceChina Department of Rheumatology Fangshan HospitalBeijing University of Chinese MedicineBeijing 102400China

In this editorial,we comment on the article by Liu et *** on our analysis of a case report,we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor(TNFi).While TNFi therapy increases the risk of reactivating latent tuberculosis,primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal *** factors for primary nasal tuberculosis include minimally invasive nasal surgery,diabetes,and human immunodefi ciency *** with early symptoms such as nasal congestion,rhinorrhea,altered olfaction,epistaxis,or ulceration,and unresponsive to conventional antibiotics and antihistamines should undergo early rhinoscopy,possibly followed by repeated tissue biopsies and acid-fast bacilli culture when *** diagnosis is challenging,it is essential to consider local tuberculosis epidemiology and the efficacy of diagnostic antituberculosis *** preferred method for tuberculosis screening is the interferon gamma release assay,with a general recommendation for screening at 3 and 6 months after initial treatment and then every six ***,the optimal frequency is not yet consensus-driven and may be increased in economically viable settings.

关键词： Tumor necrosis factor inhibitor interferon-gamma release assay Primary nasal tuberculosis Rhinoscopy Diabetes mellitus

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