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A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional chinese medicine

引用

Acta Pharmaceutica Sinica B 2021年第6期11卷 1379-1399页

作者： Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Shaanxi Institute of International Trade&Commerce Xianyang 7120462China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China

Over the past decade,traditional chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its ***,integrative pharmacology-based traditional chinese medicine(TCMIP) was proposed as a paradigm shift in *** review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of ***,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in ***,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,*** that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental ***,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.

关键词： integrative pharmacology-based traditional chinese medicine PK-PD correlations Big data Mathematical modeling Multidimensional association network

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