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injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration:current status and future perspectives

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Regenerative Biomaterials 2022年第1期9卷 1106-1130页

作者： Phuong Le Thi Dieu Linh Tran Thai Thanh Hoang Thi Yunki Lee Ki Dong Park Institute of Applied Materials Science Vietnam Academy of Science and TechnologyHo Chi Minh City 700000Vietnam Department of Orthopaedics Emory University School of MedicineAtlantaGA 30329USA Department of Molecular Science and Technology Ajou UniversitySuwon 443-749Republic of Korea

The dual role of reactive oxygen and nitrogen species(RONS)in physiological and pathological processes in biological systems has been widely reported.It has been recently suggested that the regulation of RONS levels under physiological and pathological conditions is a potential therapy to promote health and treat diseases,respectively.injectable hydrogels have been emerging as promising biomaterials for RONS-related biomedical applications owing to their excellent biocompatibility,three-dimensional and extracellular matrix-mimicking structures,tunable properties and easy functionalization.These hydrogels have been developed as advanced injectable platforms for locally generating or scavenging RONS,depending on the specific conditions of the target disease.In this review article,the design principles and mechanism by which RONS are generated/scavenged from hydrogels are outlined alongside a discussion of their in vitro and in vivo evaluations.Additionally,we highlight the advantages and recent developments of these injectable RONS-controlling hydrogels for regenerativemedicines and tissue engineering applications.

关键词： reactive oxygen/nitrogen species oxidative stress-related diseases injectable hydrogels reactive oxygen/nitrogen species-scavenging/releasing/responsive properties tissue regeneration

An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4318-4336页

作者： Jiao Zhang Qian Luo Qian Hu Tiantian Zhang Jingyu Shi Li Kong Dehao Fu Conglian Yang Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030China Department of Orthopaedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Center for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

Delayed diabetic wound healing has placed an enormous burden on society.The key factors limiting wound healing include unresolved inflammation and impaired angiogenesis.Platelet-rich plasma(PRP)gel,a popular biomaterial in the field of regeneration,has limited applications due to its non-injectable properties and rapid release and degradation of growth factors.Here,we prepared an injectable hydrogel(DPLG)based on PRP and laponite by a simple one-step mixing method.Taking advantages of the non-covalent interactions,DPLG could overcome the limitations of PRP gels,which is injectable to fill irregular injures and could serve as a local drug reservoir to achieve the sustained release of growth factors in PRP and deferoxamine(an angiogenesis promoter).DPLG has an excellent ability in accelerating wound healing by promoting macrophage polarization and angiogenesis in a full-thickness skin defect model in typeⅠdiabetic rats and normal rats.Taken together,this study may provide the ingenious and simple bioactive wound dressing with a superior ability to promote wound healing.

关键词： injectable hydrogels Diabetic wound healing Platelet-rich plasma Laponite Deferoxamine Angiogenesis Macrophage polarization

Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

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Military Medical Research 2022年第5期9卷 603-617页

作者： Yan Wang Hong-Qian Lv Xuan Chao Wen-Xin Xu Yun Liu Gui-Xia Ling Peng Zhang Shenyang Pharmaceutical University 103 Wenhua RoadShenyang 110016China Center for Nanotechnology in Drug Delivery Eshelman School of PharmacyUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Spinal cord injury(SCI)is a serious traumatic disease of the central nervous system,which can give rise to the loss of motor and sensory function.Due to its complex pathological mechanism,the treatment of this disease still faces a huge challenge.hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord.hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration to improve SCI.In this review,hydrogel-based multimodal therapeutic strategies to repair SCI are provided,and a combination of hydrogel scaffolds and other therapeutic modalities are discussed,with particular emphasis on the repair mechanism of SCI.

关键词： Spinal cord injury injectable hydrogels Hydrogel scaffolds Multimodal therapy

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

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Bioactive Materials 2022年第10期7卷 472-484页

作者： Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityOrthopedic Laboratory of Chongqing Medical UniversityNo.1 Youyi RoadYuzhong DistrictChongqing400016PR China Department of Orthopaedics Affiliated Hospital of North Sichuan Medical CollegeNo.1 the South of Maoyuan RoadNanchongSichuan637000PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis.

关键词： Boundary lubrication injectable hydrogels Shear-responsive Liposomes Osteoarthritis

The recent research progress of polyphenol-derived biomaterials in wound repair

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Biosurface and Biotribology 2023年第4期9卷 114-128页

作者： Shuya Zhao Lu Han Liwei Yan Xiong Lu Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina School of Medicine and Pharmaceutics Key Laboratory of Marine DrugsMinistry of EducationOcean University of ChinaQingdaoShandongChina

The clinical requirements for wound care are increasing daily, and the global wound dressing market is expanding;however, the research and development of new wound dressings are imminent. Natural biomolecules such as polyphenols, have been widely used in this field of vision. Owing to their unique anti-oxidative, adhesive, antibacterial and other bioactive functions, researchers have developed a series of wound dressings with excellent performance and applied them to a variety of biomaterials, such as hydrogels, nanofibers, films and scaffolds. They can effectively promote angiogenesis and fibroblast migration and proliferation, scavenge active oxygen free radicals, inhibit excessive in-flammatory reactions at wound sites and ultimately accelerate wound healing. The authors summarise the latest progress in polyphenol-derived biomaterials in skin wound repair to provide inspiration for future wound dressing research.

关键词： biomaterials biomedical application injectable hydrogels physically cross-linked gel polydopamine wound healing

A novel degradable injectable HLC-HPA hydrogel with antiinflammatory activity for biomedical materials:Preparation,characterization,in vivo and in vitro evaluation

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Science China(Technological Sciences) 2020年第11期63卷 2449-2463页

作者： GAO Shang QU LinLin ZHU ChenHui OUYANG PingKai FAN DaiDi Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an 710069China Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech&Biomed Research Institute Northwest UniversityXi’an 710069China College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjing 211816China

In situ injectable hydrogels,which have great potential in tissue engineering,are characterized by simple preparation,minimal invasiveness and adaptation to complex shapes.However,injectable hydrogels have higher requirements for biocompatibility and safety due to their use in vivo implantation.Therefore,in this study,a human-like collagen(HLC)-based in situ gel-forming injectable HLC-HPA hydrogel was synthesized by combining the amino group of HLC with the carboxyl group of HPA activated using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride(EDC)and N-hydroxysuccinimide(NHS),followed by crosslinking by horseradish peroxidase(HRP)and H_2O_2,and used as scaffold material for tissue engineering.The hydrogel stiffness,gel time and biodegradation rate could be easily and independently adjusted by varying the H_2O_2 and HRP concentrations.Scanning electron microscope(SEM)clarified the homogeneous porous and interconnected internal structures of the hydrogel.In vitro cell viability and in vivo degradation experiments confirmed that the HLC-HPA hydrogel had good biodegradability and excellent biocompatibility.Interestingly,in cultured macrophages,the HLC-HPA hydrogel showed anti-inflammatory activity by reducing the amount of the pro-inflammatory cytokines tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)and increasing the secretion of the anti-inflammatory cytokine interleukin-10(IL-10)induced by lipopolysaccharide(LPS).Meanwhile,in animal experiments,HLC-HPA hydrogels exhibit excellent biocompatibility and have properties of hemostasis and reduction of inflammatory response.Therefore,the HLC-HPA hydrogel prepared in this study has great potential for development for use in the biomedical field.

关键词： injectable hydrogels human-like collagen biocompatibility anti-inflammation hemostasis