Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

作     者：Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang 

作者机构：Department of OrthopedicsThe First Affiliated Hospital of Chongqing Medical UniversityOrthopedic Laboratory of Chongqing Medical UniversityNo.1 Youyi RoadYuzhong DistrictChongqing400016PR China Department of OrthopaedicsAffiliated Hospital of North Sichuan Medical CollegeNo.1 the South of Maoyuan RoadNanchongSichuan637000PR China Department of OrthopaedicsShanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第10期

页      面：472-484页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200) the National Natural Science Foundation of China(81873998,32101104 and 81972069) Shanghai Jiao Tong University“Medical and Research”Program(ZH2018ZDA04) 

主　　题：Boundary lubrication Injectable hydrogels Shear-responsive Liposomes Osteoarthritis 

摘      要：Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate ***,these boundary layers can be damaged by shear,resulting in decreased ***,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable ***,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining ***,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary ***,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis.