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Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode

引用

Journal of Innovative Optical Health Sciences 2021年第3期4卷 88-102页

作者： Yaqin Wan Meiqun Wang Shaorong Zhang Bingbin Xie Out-Patient Department of the Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Jiangxi Biomedical Engineering Research Center for Auditory Research 1 Minde RoadNanchang 330006P.R.China

An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition *** auditory brainstem responses(oABRs)were recorded in normal-hearing guinea pigs,and the energy thresholds,pulse durations,and ampli-tudes evoked by the varied stimulus repetitions were *** oABRs could be evoked through INS even as the repetition rate of stimulation reached 19 *** energy threshold of oABRs was elevated,the amplitudes decreased as pulse durations increased and repetition rates were higher,and the latencies were delayed as the pulse durations *** temperature variation curves on the site of stimulation significantly increased as the pulse duration increased to 400μ*** elevated the temperature around the stimulus site area via thermal accumulation during radiation,especially when higher repetition stimuli were *** results demonstrate that high repetition infrared stimulations can safely evoke stable and available oABRs in normal-hearing guinea pigs.

关键词： infrared neural stimulation implantable optrode cochlear implant spiral ganglion neuron optical stimulation

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