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Extracellular vesicles:Emerging tools as therapeutic agent carriers

Acta Pharmaceutica Sinica B 2022年第10期12卷 3822-3842页

作者： Shan Liu Xue Wu Sutapa Chandra Christopher Lyon Bo Ning Li jiang Jia Fan Tony Y.Hu Sichuan Provincial Key Laboratory for Human disease Gene Study Department of Medical GeneticsDepartment of Laboratory MedicineSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Biochemistry and Molecular Biology Center for Cellular and Molecular DiagnosisSchool of MedicineTulane UniversityNew OrleansLA 70112USA The M.O.E.Key Laboratory of Laboratory Medical Diagnostics the College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China

Extracellular vesicles(EVs)are secreted by both eukaryotes and prokaryotes,and are present in all biological fluids of vertebrates,where they transfer DNA,RNA,proteins,lipids,and metabolites from donor to recipient cells in cell-to-cell communication.Some EV components can also indicate the type and biological status of their parent cells and serve as diagnostic targets for liquid biopsy.EVs can also natively carry or be modified to contain therapeutic agents(e.g.,nucleic acids,proteins,polysaccharides,and small molecules)by physical,chemical,or bioengineering strategies.Due to their excellent biocompatibility and stability,EVs are ideal nanocarriers for bioactive ingredients to induce signal transduction,immunoregulation,or other therapeutic effects,which can be targeted to specific cell types.Herein,we review EV classification,intercellular communication,isolation,and characterization strategies as they apply to EV therapeutics.This review focuses on recent advances in EV applications as therapeutic carriers from in vitro research towards in vivo animal models and early clinical applications,using representative examples in the fields of cancer chemotherapeutic drug,cancer vaccine,infectious disease vaccines,regenerative medicine and gene therapy.Finally,we discuss current challenges for EV therapeutics and their future development.

关键词： Extracellular vesicle Therapeutic agent Delivery carrier Outer membrane vesicle Cancer therapy infectious disease vaccine Regenerative medicine Gene therapy

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