Extracellular vesicles:Emerging tools as therapeutic agent carriers

作     者：Shan Liu Xue Wu Sutapa Chandra Christopher Lyon Bo Ning Li jiang Jia Fan Tony Y.Hu 

作者机构：Sichuan Provincial Key Laboratory for Human Disease Gene StudyDepartment of Medical GeneticsDepartment of Laboratory MedicineSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Biochemistry and Molecular BiologyCenter for Cellular and Molecular DiagnosisSchool of MedicineTulane UniversityNew OrleansLA 70112USA The M.O.E.Key Laboratory of Laboratory Medical Diagnosticsthe College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第10期

页      面：3822-3842页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Tulane Weatherhead Endowment Fund (USA) 

主　　题：Extracellular vesicle Therapeutic agent Delivery carrier Outer membrane vesicle Cancer therapy Infectious disease vaccine Regenerative medicine Gene therapy 

摘      要：Extracellular vesicles(EVs)are secreted by both eukaryotes and prokaryotes,and are present in all biological fluids of vertebrates,where they transfer DNA,RNA,proteins,lipids,and metabolites from donor to recipient cells in cell-to-cell *** EV components can also indicate the type and biological status of their parent cells and serve as diagnostic targets for liquid *** can also natively carry or be modified to contain therapeutic agents(e.g.,nucleic acids,proteins,polysaccharides,and small molecules)by physical,chemical,or bioengineering *** to their excellent biocompatibility and stability,EVs are ideal nanocarriers for bioactive ingredients to induce signal transduction,immunoregulation,or other therapeutic effects,which can be targeted to specific cell ***,we review EV classification,intercellular communication,isolation,and characterization strategies as they apply to EV *** review focuses on recent advances in EV applications as therapeutic carriers from in vitro research towards in vivo animal models and early clinical applications,using representative examples in the fields of cancer chemotherapeutic drug,cancer vaccine,infectious disease vaccines,regenerative medicine and gene ***,we discuss current challenges for EV therapeutics and their future development.