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The History of Controlling and Treating infectious diseases in Ancient China

Current Medical Science 2024年第1期44卷 64-70页

作者： Cui-ling LIU Tao ZHOU Liang-bin CHENG David FISHER Khrystyna PRONYUK Erkin MUSABAEV Yi-ping DANG Lei ZHAO Department of infectious diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Gastroenterology and Hepatology Huanggang Hospital of Traditional Chinese MedicineHubei University of Chinese MedicineHuanggang 438000China Clinical College of Traditional Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Liver diseases Hubei Hospital of Traditional Chinese MedicineWuhan 430061China Department of Medical Biosciences Faculty of Natural SciencesUniversity of the Western CapeBellvilleCape Town 7535South Africa Department of infectious diseases Bogomolets National Medical UniversityKyiv 02132Ukraine The Research Institute of Virology Ministry of HealthTashkent 100122Uzbekistan Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

infectious diseases are the common enemies of *** the course of historical development,they persistently threaten human health and *** today,despite the developments in medical science,we cannot escape the fear and suffering caused by infectious *** in ancient or modern times,the source of infection,route of transmission,and a susceptible population are the three key conditions for the prevalence and spread of infectious *** factors closely related to these three conditions can affect the prevalence of infectious *** is one of the cradles of world *** ancient people accumulated a great deal of experience and lessons in the long struggle against infectious *** the face of the current threat posed by widespread infectious disease,it is imperative to review and summarize ancient Chinese ideas and health policies on epidemic prevention and control to inspire contemporary efforts in the prevention and control of infectious *** combination of prevention-oriented epidemic prevention ideology and traditional medicine provides valuable insights,especially for impoverished and medically underserved regions.

关键词： infectious diseases Chinese medicine public health historical review

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Bioactivities,Mechanisms,Production,and Potential Application of Bile Acids in Preventing and Treating infectious diseases

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Engineering 2024年第7期38卷 13-26页

作者： Shuang Liu Shuo Yang Biljana Blazekovic Lu Li Jidan Zhang Yi Wang Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

infectious diseases are a global public health problem,with emerging and re-emerging infectious diseases on the rise ***,their prevention and treatment are still major *** acids are common metabolites in both hosts and microorganisms that play a significant role in controlling the metabolism of lipids,glucose,and *** acids have historically been utilized as first-line,valuable therapeutic agents for related metabolic and hepatobiliary ***,bile acids are the major active ingredients of cow bezoar and bear bile,which are commonly used traditional Chinese medicines(TCMs)with the therapeutic effects of clearing heat,detoxification,and relieving wind and *** recent years,the promising performance of bile acids against infectious diseases has attracted attention from the scientific *** paper reviews for the first time the biological activities,possible mechanisms,production routes,and potential applications of bile acids in the treatment and prevention of infectious *** with previous reviews,we comprehensively summarize existing studies on the use of bile acids against infectious diseases caused by pathogenic microorganisms that are leading causes of global morbidity and *** addition,to ensure a stable supply of bile acids at affordable prices,it is necessary to clarify the biosynthesis of bile acids in vivo,which will assist scientists in elucidating the accumulation of bile acids and discovering how to engineer various bile acids by means of chemosynthesis,biosynthesis,and chemoenzymatic ***,we explore the current challenges in the field and recommend a development strategy for bile-acid-based drugs and the sustainable production of bile *** presented studies suggest that bile acids are potential novel therapeutic agents for managing infectious diseases and can be artificially synthesized in a sustainable way.

关键词： Bile acids infectious diseases Bioactivities Mechanisms Anti-infective agents

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The exploration of cell population data in clinical use: Beyond infectious diseases

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iLABMED 2024年第2期2卷 125-140页

作者： Shayuanzi Huang Yin Liu Liu Qian Juan Zhou Dong Wang Department of Laboratory Medicine the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Guangxi Hospital Division of the First Affiliated HospitalSun Yat-Sen UniversityNanningGuangxiChina Department of Medical Affair Danaher Diagnostic PlatformShanghaiChina Department of Oncology General Hospital of the Southern Theatre CommandPLAGuangzhouGuangdongChina

Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given *** parameters harbor information associated with cell morphology and can be automatically generated using modern hematological *** studies have revealed many unique clinical applications for CPD,especially for infectious diseases,such as *** example,one monocyte-related CPD parameter is the monocyte distribution width(MDW),which can be generated using a Beckman Coulter hematological *** has received FDA and CE approval for aiding in sepsis diagnosis in adult patients in the emergency ***,MDW can serve as a diagnostic biomarker in patients infected with *** has also been widely explored for possible clinical applications beyond infectious dis-eases,such as for predicting myelodysplastic syndromes,screening for he-matological malignancies,and detecting sterile *** parameter measurements are easily obtained and quite cost-effective,making them practical for clinical ***,there are some potential drawbacks of CPD *** pre-analytical conditions can affect CPD ***-more,CPD are specific to certain hematological analyzers and the result cannot be transferred between different *** practical usefulness of CPD reference intervals is also still *** this review,wesummarize the current studies related to CPD and its clinical *** well-designed clinical studies related to CPD are still expected.

关键词： cell population data Coulter principle hematology analyzer infectious diseases white blood cell

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Aggregation-induced emission:recent applications in infectious diseases

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Science China Chemistry 2023年第11期66卷 2986-3005页

作者： Meijia Gu Luojia Chen Rui Hu Qingrong Chen Jianbo Liu Lianrong Wang Shi Chen Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug DiscoveryTaiKang Center for Life and Medical SciencesZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Respiratory diseases The Research and Application Center of Precision MedicineThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450014China

infectious diseases are caused by various pathogenic microorganisms that break through the human immune barrier,then reproduce and mutate in human cells,thus causing invasive *** many recent scientific and technological advances in fields,such as genetics,chemistry,and protein engineering,and in the efficiency of drug research and development,the discovery and development of novel and potent anti-infectious disease agents have still lagged *** is often challenging to keep up with the emergence and mutation of new pathogenic microorganisms,which leads to the emergence of more resistant pathogenic *** emergence of aggregation-induced emission(AIE)fluorogens with high luminescence yields and high reactive oxygen species(ROS)production rates provides scientists with a new strategy for the prevention and treatment of pathogenic *** to their advantages in terms of brightness,biocompatibility,photostability,and positive correlation,AIE fluorogens(AIEgens)have great potential in biological *** review presents a systemic overview of recent progress in AIEgen-based platforms for the photodynamic therapy(PDT)of infectious diseases,which has emerged as a promising noninvasive alternative to traditional antibiotics for combating the drug resistance of infectious *** review is mainly divided into two parts according to the type of pathogenic microorganisms:a section on bacterial and fungal infections(e.g.,eye,skin,oral cavity,and blood infections),and a section on viral *** future prospects and potential clinical applications of AIEgens are also discussed in *** addition to motivating further interest in this field,this review is intended to promote ideas for the further exploration of AIEgens and the development of more advanced AIEgens in a broader range of biomedical and clinical applications.

关键词： aggregation-induced emission infectious diseases photosensitizers photodynamic therapy pathogenic microorganisms

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Application of Nanopore Sequencing Technology in the Clinical Diagnosis of infectious diseases

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Biomedical and Environmental Sciences 2022年第5期35卷 381-392页

作者： ZHANG Lu Lu ZHANG Chi PENG Jun Ping NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100176China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100176China

infectious diseases are an enormous public health burden and a growing threat to human health *** or classic recurrent pathogens,or pathogens with resistant traits,challenge our ability to diagnose and control infectious *** sequencing technology has the potential to enhance our ability to diagnose,interrogate,and track infectious diseases due to the unrestricted read length and system *** review focuses on the application of nanopore sequencing technology in the clinical diagnosis of infectious diseases and includes the following:(i)a brief introduction to nanopore sequencing technology and Oxford Nanopore Technologies(ONT)sequencing platforms;(ii)strategies for nanopore-based sequencing technologies;and(iii)applications of nanopore sequencing technology in monitoring emerging pathogenic microorganisms,molecular detection of clinically relevant drug-resistance genes,and characterization of disease-related microbial ***,we discuss the current challenges,potential opportunities,and future outlook for applying nanopore sequencing technology in the diagnosis of infectious diseases.

关键词： Nanopore sequencing infectious diseases Pathogen Oxford Nanopore Technologies

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Role of ultrasound in the treatment of pediatric infectious diseases:case series and narrative review

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World Journal of Pediatrics 2023年第1期19卷 20-34页

作者： Takahiro Hosokawa Yutaka Tanami Yumiko Sato Kuntaro Deguchi Haruka Takei Eiji Oguma Department of Radiology Saitama Children's Medical Center1-2 Shintoshin Chuo-kuSaitama 330-8777Japan Department of infectious diseases and Immunology Saitama Children's Medical CenterSaitamaJapan

Background infectious diseases are common in pediatric *** these patients,ultrasound is a useful imaging modality that involves no irradiation or sedation and can be performed repeatedly at the patient's *** purpose of this review was to show pediatric cases with infectious disease that used ultrasound to decide the methods of *** sources Literature review was performed using Pubmed as the medical database *** year-of-publication restric-tion was *** mesh terms used were:"ultrasound","sonography","infectious disease","treatment","antibiotics","surgical intervention","pediatric","children","deep neck abscess","pyothorax","empyema","pneumonia","urinary tract infection","intra-abdominal abscess","soft tissue infection","septic arthritis","osteomyelitis",and"surgical site infection".Results We presented pediatric case series with infectious diseases,including deep neck abscess,pyothorax and empyema,pneumonia,urinary tract infection,intra-abdominal abscess,soft tissue infection,septic arthritis and osteomyelitis,and surgical-site *** was useful for evaluating the extent and location of inflammation and abscess and for decision-making concerning surgical *** Knowledge of these sonographic findings is important for sonographers during examinations and for physicians when determining the treatment plan and period of antibiotic therapy for infected lesions.

关键词： infectious diseases Intra-abdominal abscess Osteomyelitis Pyothorax Ultrasound

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Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases

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Cellular & Molecular Immunology 2023年第6期20卷 600-612页

作者： Annu Devi Isha Pahuja Shashi Prakash Singh Akanksha Verma Debapriya Bhattacharya Ashima Bhaskar Ved Prakash Dwivedi Gobardhan Das Special Centre for Molecular Medicine Jawaharlal Nehru UniversityNew DelhiIndia Immunobiology Group International Centre for Genetic Engineering and Biotechnology New DelhiIndia Department of Molecular Medicine Jamia Hamdard UniversityNew DelhiIndia Centre for Biotechnology Siksha O Anusandhan UniversityBhubneshwarOdishaIndia

Mesenchymal stem cells(MsCs)play diverse roles ranging from regeneration and wound healing to immune *** investigations have indicated the crucial role of these multipotent stem cells in regulating various aspects of the immune *** express unique signaling molecules and secrete various soluble factors that play critical roles in modulating and shaping immune responses,and in some other cases,MSCs can also exert direct antimicrobial effects,thereby helping with the eradication of invading ***,it has been demonstrated that MSCs are recruited at the periphery of the granuloma containing Mycobacterium tuberculosis and exert"Janus"-like functions by harboring pathogens and mediating host protective immune *** leads to the establishment of a dynamic balance between the host and the *** function through various immunomodulatory factors such as nitric oxide(NO),IDO,and immunosuppressive ***,our group has shown that *** uses MSCs as a niche to evade host protective immune surveillance mechanisms and establish *** also express a large number of ABC efflux pumps;therefore,dormant *** residing in MSCs are exposed to a suboptimal dose of ***,it is highly likely that drug resistance is coupled with dormancy and originates within *** this review,we discussed various immunomodulatory properties of MsCs,their interactions with important immune cells,and soluble *** also discussed the possible roles of MsCs in the outcome of multiple infections and in shaping the immune system,which may provide insight into therapeutic approaches using these cells in different infection models.

关键词： Mesenchymal Stem Cells(MsCs) Macrophages Tuberculosis infectious diseases T cells Immunomodulation Immunotherapy.

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Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1126-1147页

作者： Yesi Shi Hongyan Qian Peishi Rao Dan Mu Yuan Liu Gang Liu Zhongning Lin State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China Department of Rheumatology and Clinical Immunology The First Affiliated Hospital of Xiamen UniversityXiamen 361102China

Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and *** has a great potential in modulating immune ***,biomimetic nanomodulators can be designed for prevention,diagnosis and therapy to achieve a better targeted *** the development of materials science and bioengineering,a wide range of membranecoated nanomodulators are ***,we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious *** also rethink the challenges or limitations in the progress of the therapeutic nanoplatform,and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.

关键词： Biomimetic membrane Nanomodulators Immune system Bioengineering Immunotherapy Autoimmune infectious diseases

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Soluble triggering receptor expressed on myeloid cell-1 （sTREM- 1）： a potential biomarker for the diagnosis of infectious diseases

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Frontiers of Medicine 2017年第2期11卷 169-177页

作者： Changlin Cao Jingxian Gu Jingyao Zhang Department of Pulmonary Medicine Chenzhou No. 1 People 's Hospital Chenzhou 423000 China Department of Hepatobiliary Surgery the First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 China Department of SICU the First Affiliated Hospital of Xi'an Jiaotong University Xi 'an 710061 China

Sensitive and useful biomarkers for the diagnosis and prognosis of infectious diseases have been widely developed. An example of these biomarkers is triggering receptor expressed on myeloid cell-1 （TREM-1）, which is a cell surface receptor expressed on monocytes/macrophages and neutrophils. TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway. This pathway is triggered by the interaction of TREM-1 with ligands or stimulation by bacterial lipopolysaccharide. Consequently, pro-inflammatory cytokines and chemokines are secreted. Soluble TREM-1 （sTREM-1） is a special form of TREM-1 that can be directly tested in human body fluids and well-known biomarker for infectious diseases, sTREM-1 level can be potentially used for the early diagnosis and prognosis prediction of some infectious diseases, including infectious pleural effusion, lung infections, sepsis, bacterial meningitis, viral infections （e.g., Crimean Congo hemorrhagic fever and dengue fever）, fungal infections （e.g., Aspergillus infection）, and burn-related infections, sTREM-1 is a more sensitive and specific biomarker than traditional indices, such as C-reactive protein and procalcitonin levels, for these infectious diseases. Therefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of infectious diseases.

关键词： soluble triggering receptor expressed on myeloid cells-l infectious diseases diagnosis and prognosis biomarker

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Analysis of Monitoring,Early Warning and Emergency Response System for New Major infectious diseases in China and Overseas

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Current Medical Science 2021年第1期41卷 62-68页

作者： Xing-li DU Xin-rui ZHAO Huan GAO Wan-wan SHEN Jia-zhi LIAO Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In recent years,the impact of new major infectious diseases on people’s normal life is becoming more and more frequent,which has brought great impact on people’s life safety and social economy,especially the corona virus disease 2019,which has been sweeping the *** health and disease prevention and control systems in different countries have different performances in response to the pandemic,but they all have exposed many *** around the world urgently need to improve the monitoring,early warning and emergency response systems for new major infectious *** the outpost and main part of medical rescue,the hospital urgently needs to establish a set of scientifically advanced emergency response mechanism that is suitable for the business process of the medical system and unified standards in order to improve the response efficiency and quality of emergency treatment.

关键词： infectious diseases monitoring emergency response hospital

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