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Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects:Reconstruction,anti-infection,and osseointegration

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Bioactive Materials 2024年第12期42卷 18-31页

作者： Teng Zhang Wenhao Zhou Wanliang Yang Jingwei Bi Hao Li Xianlei Gao Baoliang Zhang Guidong Shi Ka Li Zhijian Wei Xin Pan Shiqing Feng Department of Orthopedics Qilu Hospital of Shandong UniversityJinan250012China Shaanxi Key Laboratory of Biomedical Metallic Materials Northwest Institute for Non-ferrous Metal ResearchXi’an710016China International Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina

infected bone defect is a formidable clinical *** approaches to prevention and treatment for infected bone defects are *** key elements of the treatment are bone defect reconstruction,antiinfection,and *** treatment methods remain unsatisfactory owing to the absence of composite integrating materials with anti-infective,and osteogenic activities as well as proper mechanical strength at the same *** this study,we fabricated a vancomycin-encapsulated hydrogel with bacteriaresponsive release properties combined with a shaved porous(submicron-micron)three-dimensional-printed Ti6Al4V *** implant surface,modified with submicron-sized pores through microarc oxidation(MAO),showed enhanced osteogenic activity and integrated well with the hydrogel drug release system,enabling sustained vancomycin *** vitro experiments underscored the commendable antibacterial ability,biosafety,and osteoinductive *** antibacterial and osteogenic abilities of the implant were further demonstrated in vivo in infected rabbit bone *** results showed that the vancomycinencapsulated hydrogel-loaded microarc-oxidized 3D-printed porous Ti6Al4V can repair the infected bone defects with satisfactory anti-infection and osseointegration effects.

关键词： Porous Ti6Al4V implants infected bone defects Anti-infection Osseointegration

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Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin

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Bioactive Materials 2023年第6期24卷 450-462页

作者： Hu Qian Ting Lei Long Hua Yu Zhang Dongyu Wang Jiangyu Nan Wenbin Liu Yan Sun Yihe Hu Pengfei Lei Department of Orthopedic Surgery Xiangya Hospital Central South UniversityChangsha410008China Department of Orthopedic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityChina Department of Orthopaedic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyiChina Xiangya School of Medicine Central South UniversityChangsha410008China

infected bone defects(IBDs)remains a challenging problem for ***,routine management for IBDs has two stages:debridement and systematic antibiotics administration to control infection,and secondary grafting to repair bone *** the efficacy is not satisfactory,because the overuse of antibiotics may lead to systemic toxicity,and the emergence of drug-resistant bacteria,as well as the secondary surgery would cause additional trauma and economic burden to the ***,it is imperative to develop a novel scaffold for one-stage repair of *** this study,vancomycin(Van)was encapsulated into poly(lactic co-glycolic acid)(PLGA)microspheres through the double emulsion method,which were then loaded into the additively-manufactured porous tantalum(AM-Ta)through gelatin methacryloyl(GelMA)hydrogel to produce the composite Ta/GelMA hydrogel(Gel)/PLGA/vancomycin(Van)scaffolds for repairing *** characterization of the newly-developed scaffold indicated that the releasing duration of Van was over 2 *** experiments indicated good biocompatibility of the composite scaffold,as well as bacteriostasis and osteointegration properties,which showed great potential for clinical *** construction of this novel scaffold would provide new sight into the development of orthopaedic implants,shedding a novel light on the treatment of IBDs.

关键词： infected bone defects Porous tantalum PLGA microspheres Vancomycin

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