Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects:Reconstruction,anti-infection,and osseointegration

作     者：Teng Zhang Wenhao Zhou Wanliang Yang Jingwei Bi Hao Li Xianlei Gao Baoliang Zhang Guidong Shi Ka Li Zhijian Wei Xin Pan Shiqing Feng 

作者机构：Department of OrthopedicsQilu Hospital of Shandong UniversityJinan250012China Shaanxi Key Laboratory of Biomedical Metallic MaterialsNorthwest Institute for Non-ferrous Metal ResearchXi’an710016China International Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第42卷第12期

页      面：18-31页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the National Natural Science Foundation of China[grant number 82202729] the Natural Science Foundation of Shandong Province[grant number ZR2022QH261] the Taishan Scholar Project of Shandong Province[grant number tsqn202306355] the National Natural Science Foundation of China[grant number 32101087] the Tianjin Municipal Science and Technology Program(21JCZDJC01100) 

主　　题：Porous Ti6Al4V implants Infected bone defects Anti-infection Osseointegration 

摘      要：Infected bone defect is a formidable clinical *** approaches to prevention and treatment for infected bone defects are *** key elements of the treatment are bone defect reconstruction,antiinfection,and *** treatment methods remain unsatisfactory owing to the absence of composite integrating materials with anti-infective,and osteogenic activities as well as proper mechanical strength at the same *** this study,we fabricated a vancomycin-encapsulated hydrogel with bacteriaresponsive release properties combined with a shaved porous(submicron-micron)three-dimensional-printed Ti6Al4V *** implant surface,modified with submicron-sized pores through microarc oxidation(MAO),showed enhanced osteogenic activity and integrated well with the hydrogel drug release system,enabling sustained vancomycin *** vitro experiments underscored the commendable antibacterial ability,biosafety,and osteoinductive *** antibacterial and osteogenic abilities of the implant were further demonstrated in vivo in infected rabbit bone *** results showed that the vancomycinencapsulated hydrogel-loaded microarc-oxidized 3D-printed porous Ti6Al4V can repair the infected bone defects with satisfactory anti-infection and osseointegration effects.