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A new indole alkaloid from Nauclea officinalis(Pierre ex Pitard) Merr. et Chun

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Journal of Chinese Pharmaceutical Sciences 2014年第5期23卷 306-310页

作者：皮晓雪谢可辉涂光忠蔡田芝杨蓉吴琼付宏征北京大学医学部天然药物与仿生药物国家重点实验室北京100191 北京微量化学研究所北京100191

From the aerial parts ofNauclea officinalis （Pierre ex Pitard） Merr. et Churl, one new indole alkaloid paratunamide E （1） has been isolated together with six known indole alkaloids, paratunamide A （2）, nauclealotide C （3）, nauclealotide A （4）, vincosamide （5）, strictosamide （6） and naucleamide F （7）. Naucleamide F （7） was isolated from Nauclea officinalis for the first time. All of the seven compounds above were elucidated by spectroscopic methods including 1 D and 2 D NMR soectroscoDic analyses.

关键词： Nauclea officinalis indole alkaloid Structural identification

indole alkaloids from the Roots of Ervatamia hainanensis

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Chinese Chemical Letters 2006年第6期17卷 779-782页

作者： Jian Peng HUANG Zi Ming FENG Chong Fei ZHENG Pei Cheng ZHANG Yang Min MA Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 College of Life Science Northwest A-F University Yangling Shaanxi 712100

Two new indole alkaloids, named ibogamine-18-carboxylic acid, 3, 4-didehydro-7, 8-dioxo-methyl ester 1, ibogamine-18-carboxylic acid, 16, 17-didehydro-9, 17-dihydro-9-hydroxy （2-oxopropyl）-methyl ester 2, were isola... 详细信息

关键词： Ervatamia hainanensis indole alkaloid ibogamine-18-carboxylic acid 3 4-didehydro-7 8-dioxo-methyl ester ibogamine- 18-carboxylic acid 16 17-didehydro-9 17-dihydro-9-hydroxy-(2-oxopropyl)-methyl ester.

Antimicrobial indole alkaloids from Tabernaemontana corymbosa

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Chinese Journal of Natural Medicines 2023年第2期21卷 146-153页

作者： FAN Kun ZHANG Lanchun TAN Bangyin Guy S.S.Njateng QIN Malong GUO Ruirong HUANG Xiaojuan DING Cai-feng GAO Weimin ZHANG Rongping YU Haofei School of Pharmaceutical Sciences Department of Zoology&Yunnan Key Laboratory of Pharmacology for Natural ProductsKunming Medical UniversityKunming 650500China School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Resources Yunnan University of Traditional Chinese MedicineKunming 650500China Department of Biochemistry Faculty of ScienceUniversity of DschangDschangCameroon

Four unreported monoterpene indole alkaloids,tabernaecorymines B−E(1−4),together with twenty-one known indole alkaloids(5−25)were obtained from the stem bark of Tabernaemontana *** structures and absolute configurations were elucidated by extensive spectroscopy,quantum chemical calculations,DP4+probability analyses and Mo2(OAc)4-induced electronic circular dichroism *** antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis,Streptococcus dysgalactiae and Candida albicans.

关键词： Tabernaemontana corymbosa indole alkaloid Antimicrobial activity

Marine-derived fungi as a source of bioactive indole alkaloids with diversifed structures

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Marine Life Science & Technology 2021年第1期3卷 44-61页

作者： Zhi-Hui Meng Tian-Tian Sun Guo-Zheng Zhao Yu-Fei Yue Qing-Hua Chang Hua-Jie Zhu Fei Cao College of Pharmaceutical Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China

Marine-derived fungi are well known as rich sources of bioactive natural *** evidences indicated that indole alkaloids,isolated from a variety of marine-derived fungi,have attracted considerable attention for their diverse,challenging structural complexity and promising bioactivities,and therefore,indole alkaloids have potential to be pharmaceutical lead *** compilation of the relevant *** this review,we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities,covering literatures published during 1982–2019.

关键词： indole alkaloid Marine-derived fungus Chemical diversity Bioactivity

Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis

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Green Synthesis and Catalysis 2022年第1期3卷 25-39页

作者： Xiao-Yu Liu Yong Qin Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610041 China

Asymmetric catalysis has continued to enable the preparation of optically active natural products over the past *** minireview summarizes progress in the catalytic enantioselective total synthesis of complex monoterpenoid indole alkaloids covering the reports from 2019 to June *** particular,the generation of the key chiral stereogenic centers with metal catalysts and organocatalysts has been highlighted,showcasing the power of asymmetric catalysis protocols in accessing complex molecular architectures.

关键词： Asymmetric catalysis Total synthesis indole alkaloid Natural product Enantioselectivity

Four new indole alkaloids from Plantago asiatica

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Natural Products and Bioprospecting 2012年第6期2卷 249-254页

作者： Zhong-Hua GAO Ling-Mei KONG Xi-Sheng ZOU Yi-Ming SHI Shan-Zhai SHANG Huai-Rong LUO Cheng-Qin LIANG Xiao-Nian LI Yan LI Xue DU Wei-Lie XIAO Han-Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Four new indole alkaloids,plasiaticines A-D(1-4),together with two known ones,were isolated from the seeds of Plantago *** structures of the new compounds were elucidated on the basis of comprehensive analysis of spectroscopic *** compounds were tested for their cytotoxic activity,and all compounds except 4 were tested for their acetylcholinesterase(AChE)inhibitory activities.

关键词： Plantago asiatica indole alkaloid AChE inhibitory activity cytotoxic activity

Three new indole alkaloids from Rauvolfia yunnanensis

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Natural Products and Bioprospecting 2011年第3期1卷 104-107页

作者： Yuan GAO Fei WANG Dong-Sheng ZHOU Yan LI Ji-Kai LIU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China BioBioPha Co. Ltd.Kunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100049China

One rare tetracyclic macroline-type indole alkaloid,named rauvoyunine A(1),and two new picraline-type alkaloids rauvoyunines B and C(2 and 3)were isolated from the aerial parts of Rauvolfia *** structures were elucidated on the basis of extensive spectroscopic *** 2 and 3 were evaluated for their in vitro cytotoxicity against five human tumor cell lines.

关键词： Rauvolfia yunnanensis indole alkaloid rauvoyunine

Unified total synthesis of eburnamine-vincamine indole alkaloids based on catalytic asymmetric hydrogenation/lactamization cascade

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Green Synthesis and Catalysis 2022年第3期3卷 291-293页

作者： Wen Zhang Yansong Xue Srihari Konduri Guodan Lin Mengjuan Wu Pei Tang Fener Chen Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China Skaggs School of Pharmacy and Pharmaceutical Science UC San Diego9500 Gilman DriveLa JollaCA 92093-0934United States

The enantioselective total synthesis of representative members of the eburnamine-vincamine alkaloids(+)-vincamine,(-)-eburnamonine,and(-)-criocerine has been *** synthesis took advantage of a highly stereoselective Ir-catalyzed hydrogenation/lactamization cascade reaction,which allows for the stereo-selective construction of the C/D rings as well as the installation of the critical cis-C20/C21 relative stereo-chemistry of the eburnamine-vincamine alkaloid skeleton in one pot.

关键词： indole alkaloid Imine Asymmetric hydrogenation Natural product Enantioselective synthesis

Rauvotetraphyllines A-E, new indole alkaloids from Rauvolfia tetraphylla

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Natural Products and Bioprospecting 2012年第2期2卷 65-69页

作者： Yuan GAO Dong-Sheng ZHOU Ling-Mei KONG Ping HAI Yan LI Fei WANG Ji-Kai LIU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China BioBioPha Co. Ltd.Kunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100039China

Five new indole alkaloids rauvotetraphyllines A-E(1-5),together with eight known analogues,were isolated from the aerial parts of Rauvolfia *** structures were established by means of spectroscopic methods.

关键词： Rauvolfia tetraphylla indole alkaloid rauvotetraphylline