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Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice

Neuroscience Bulletin 2023年第4期39卷 602-616页

作者： Jun Zhou Wen Deng Chen Chen Junya Kang Xiaodan Yang Zhaojuan Dou Jiancheng Wu Quancong Li Man Jiang Man Liang Yunyun Han Department of Neurobiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Physiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Forensic Toxicology Ministry of Public SecurityBeijing100192China

Methcathinone(MCAT)belongs to the designer drugs called synthetic cathinones,which are abused worldwide for recreational purposes.It has strong stimulant effects,including enhanced euphoria,sensation,alertness,and empathy.However,little is known about how MCAT modulates neuronal activity in vivo.Here,we evaluated the effect of MCAT on neuronal activity with a series of functional approaches.C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold,especially in sensory and motor cortices,striatum,and midbrain motor nuclei.in vivo single-unit recording and two-photon Ca^(2+) imaging revealed that a large proportion of neurons increased spiking activity upon MCAT administration.Notably,MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability,specifically during a natural movie stimulus.It improved the information-processing efficiency by enhancing the single-neuron coding capacity,suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.

关键词： Methcathinone Synthetic psychoactive substance in vivo single-unit recording Ca^(2+)imaging Nucleus accumbens Visual cortex

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