Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice
作者机构:Department of NeurobiologySchool of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute for Brain ResearchCollaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan430030China Department of Forensic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of PhysiologySchool of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Forensic ToxicologyMinistry of Public SecurityBeijing100192China
出 版 物:《Neuroscience Bulletin》 (神经科学通报(英文版))
年 卷 期:2023年第39卷第4期
页 面:602-616页
核心收录:
学科分类:0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学]
基 金:supported by the National Natural Science Foundation of China(31871089 and 31871028) Junior Thousand Talents Program of China,Fundamental Research Funds for the Central Universities(HUST:2172019kfyXKJC077 and HUST:2172019kfyRCPY064) Key Laboratory of Forensic Toxicology,Ministry of Public Security of China(Beijing Municipal Public Security Bureau:2020FTDWFX02 and 2019FTDWFX06)
主 题:Methcathinone Synthetic psychoactive substance In vivo single-unit recording Ca^(2+)imaging Nucleus accumbens Visual cortex
摘 要:Methcathinone(MCAT)belongs to the designer drugs called synthetic cathinones,which are abused worldwide for recreational *** has strong stimulant effects,including enhanced euphoria,sensation,alertness,and ***,little is known about how MCAT modulates neuronal activity in ***,we evaluated the effect of MCAT on neuronal activity with a series of functional approaches.C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold,especially in sensory and motor cortices,striatum,and midbrain motor *** vivo single-unit recording and two-photon Ca^(2+) imaging revealed that a large proportion of neurons increased spiking activity upon MCAT ***,MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability,specifically during a natural movie *** improved the information-processing efficiency by enhancing the single-neuron coding capacity,suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.