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Recent advances in lung-on-a-chip technology for modeling respiratory disease

生物设计与制造(英文) 2023年第5期6卷 563-585页

作者： Jorge A.Tavares-Negrete Prativa Das Sahar Najafikhoshnoo Steven Zanganeh Rahim Esfandyarpour Department of Electrical Engineering University of CaliforniaIrvineCA 92697USA Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA Henry Samueli School of Engineering University of CaliforniaIrvineCA 92697USA Laboratory for Integrated Nano Bio Electronics Innovation Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92697USA Department of Bioengineering University of Massachusetts DartmouthDartmouthMAUSA

Tissue engineering approaches,including those to functional lung tissues,are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in *** culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent *** review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory *** identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells,as well as their application in modeling lung diseases caused by external factors such as smoking and *** possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is ***,the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced,reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.

关键词： Lung-on-a-chip in vitromodeling Lung pathophysiology Respiratory diseases 3D culturemodel

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