Recent advances in lung-on-a-chip technology for modeling respiratory disease

作     者：Jorge A.Tavares-Negrete Prativa Das Sahar Najafikhoshnoo Steven Zanganeh Rahim Esfandyarpour Jorge A.Tavares-Negrete;Prativa Das;Sahar Najafikhoshnoo;Steven Zanganeh;Rahim Esfandyarpour

作者机构：Department of Electrical EngineeringUniversity of CaliforniaIrvineCA 92697USA Department of Biomedical EngineeringUniversity of CaliforniaIrvineCA 92697USA Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Laboratory for Integrated Nano Bio Electronics InnovationHenry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Department of Mechanical and Aerospace EngineeringUniversity of CaliforniaIrvineCA 92697USA Department of BioengineeringUniversity of Massachusetts DartmouthDartmouthMAUSA 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2023年第6卷第5期

页      面：563-585页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Henry Samueli School of Engineering UC MEXUS-CONACYT University of California, UC University of California, Irvine, UCI Consejo Nacional de Ciencia y Tecnología, CONACYT 

主　　题：Lung-on-a-chip In vitromodeling Lung pathophysiology Respiratory diseases 3D culturemodel 

摘      要：Tissue engineering approaches,including those to functional lung tissues,are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in *** culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent *** review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory *** identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells,as well as their application in modeling lung diseases caused by external factors such as smoking and *** possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is ***,the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced,reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.