检索结果-南通市图书馆

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments in vivo and in vitro

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人COMT介导的木犀草素体内外甲基化代谢的区域选择性研究(英文)

人COMT介导的木犀草素体内外甲基化代谢的区域选择性研究(英文)

引用

第十届全国药物和化学异物代谢学术会议暨第三届国际ISS...

作者： CHEN Zhong-Jian,DAI Yan-Qing,KONG Si-Si,SONG Fei-Feng,LI Li-Ping,ZHOU Hui,ZENG Su,JIANG Hui-Di Department of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,866 Yuhangtang Road,Hangzhou 310058,PR.China

Aim Luteolin(3’,4’,5,7-tetrahydroxyflavone)is a typical flavonoid widely distributed in plants,which possesses many biological *** to its catecholic ring,luteolin could be methylated at meta- or para-hydroxyl in B ***,the methylated luteolin still displayed *** there was lack of information about the methylation of luteolin in *** present study aims to elucidate the regioselective methylation of luteolin in vitro and in *** Recombinant human COMT(rhCOMT)and human liver S9(HLS9)were utilized to study the kinetics of meta(3’)- and para(4’)-methylation of luteolin,and urine samples from volunteers after giving a luteolin containing formulation were collected to determine the ratio of meta-/para-production in vivo. Furthermore,metabolism stability of the meta- and para-methylated luteolin was evaluated with human liver microsomes(HLM)and recombinant human CYP450s(rhCYP450s),and a series of typical inhibitors of CYP450s were utilized to identify the CYP450 isoforms contributing to further metabolism of meta- and para-methylated *** The kinetics study showed that,V values(in rhCOMT/HLS9)for meta- and para-methylation were 0.784±0.044/0.067 3±0.002 2 and 1.17±0.082/0.097 9±0.002 4 nmol mg proteinmin,respectively;Km values for meta and para-methylation were 0.673±0.097/0.769±0.13 and 0.706±0.147/0.751±0.63μM,*** ratio of meta-/para-methylation in Clint(Vmax/Km)for rhCOMT and HLS9 were 1.43 and ***. Both meta- and para-methylated luteolin were also detected in human urine after dosing of luteolin,but the ratio of meta-/ para-mathylated luteolin was 0.528±0.14,which contrasted with the in vitro ***,CYP450s,especially CYPIA2 and CYP3A4,preferentially demethylate the para-methylated-luteolin,which might result in different ratios of meta-/para-production between in vivo and in *** Luteolin could be meta- and para-methylated by human COMT,which displayed a preferenc

关键词： Luteolin human COMT Regioselective methylation human in vivo and in vitro

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：