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Advances in single-cell sequencing:insights from organ transplantation

Military Medical Research 2022年第1期9卷 86-97页

作者： Ying Wang Jian-Ye Wang Angelika Schnieke Konrad Fischer Ying Wang and Jian-Ye Wang have contributed equally to this review Chair of Livestock Biotechnology School of Life Sciences WeihenstephanTechnical University of MunichLiesel Beckman Str i85354 FreisingGermany

Single-cell RNA sequencing(scRNA-seq)is a comprehensive technical tool to analyze intracellular and intercellular interaction data by whole transcriptional profile ***,we describe the application in biomedical research,focusing on the immune system during organ transplantation and *** conventional transcriptome analysis,this method provides a full map of multiple cell populations in one specific tissue and presents a dynamic and transient unbiased method to explore the progression of allograft dysfunction,starting from the stress response to final graft *** promising sequencing technology remarkably improves individualized organ rejection treatment by identifying decisive cellular subgroups and cell-specific interactions.

关键词： Single-cell RNA sequencing Transplant rejection immune cell interactions Transcriptional profiling 10×Genomics chromium

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Clinical implications of interleukins-31, 32, and 33 in gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1808-1822页

作者： Qing-Hua Liu Ji-Wei Zhang Lei Xia Steven G Wise Brett David Hambly Kun Tao Shi-San Bao Department of Pathology Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Surgery The Central Hospital of Songjiang DistrictShanghai Jiaotong UniversityShanghai 201699ShanghaiChina Faculty of Medicine and Health School of Medical SciencesUniversity of SydneySydney 2006NSWAustralia Department of Pathology Tongren HospitalShanghai 200336China

BACKGROUND Gastric cancer(GC) is one of the most common malignancies in China with a high morbidity and *** To determine whether interleukin(IL)-31, IL-32, and IL-33 can be used as biomarkers for the detection of GC, via evaluating the correlations between their expression and clinicopathological parameters of GC *** Tissue array(n = 180) gastric specimens were utilised. IL-31, IL-32, and IL-33 expression in GC and non-GC tissues was detected immunohistochemically. The correlations between IL-31, IL-32, and IL-33 expression in GC and severity of clinicopathological parameters were evaluated. Survival curves were plotted using the Kaplan-Meier method/Cox regression. Circulating IL-31, IL-32, and IL-33 were detected by *** We found that the expression levels of IL-31, IL-32, and IL-33 were all lower in GC than in adjacent non-GC gastric tissues(P < 0.05). IL-33 in peripheral blood of GC patients was significantly lower than that of healthy individuals(1.50 ± 1.11 vs 9.61 ± 8.00 ng/m L, P <0.05). Decreased IL-31, IL-32, and IL-33 in GC were observed in younger patients(< 60 years), and IL-32 and IL-33 were lower in female patients(P < 0.05). Higher IL-32 correlated with a longer survival in two GC subgroups: T4 invasion depth and TNM I-II stage. Univariate/multivariate analysis revealed that IL-32 was an independent prognostic factor for GC in the T4 stage subgroup. Circulating IL-33 was significantly lower in GC patients at TNM stage IV than in healthy people(P < 0.05).CONCLUSION Our findings may provide new insights into the roles of IL-31, IL-32, and IL-33 in the carcinogenesis of GC and demonstrate their relative usefulness as prognostic markers for GC. The underlying mechanism of IL-31, IL-32, and IL-33 actions in GC should be further explored.

关键词： Diagnosis and therapy Gastric cancer immune cell interactions Interleukin-31 Interleukin32 Interleukin-33

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