Clinical implications of interleukins-31, 32, and 33 in gastric cancer

作     者：Qing-Hua Liu Ji-Wei Zhang Lei Xia Steven G Wise Brett David Hambly Kun Tao Shi-San Bao 

作者机构：Department of PathologyXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of SurgeryThe Central Hospital of Songjiang DistrictShanghai Jiaotong UniversityShanghai 201699ShanghaiChina Faculty of Medicine and HealthSchool of Medical SciencesUniversity of SydneySydney 2006NSWAustralia Department of PathologyTongren HospitalShanghai 200336China 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第9期

页      面：1808-1822页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China No. 81502030 

主　　题：Diagnosis and therapy Gastric cancer Immune cell interactions Interleukin-31 Interleukin32 Interleukin-33 

摘      要：BACKGROUND Gastric cancer(GC) is one of the most common malignancies in China with a high morbidity and *** To determine whether interleukin(IL)-31, IL-32, and IL-33 can be used as biomarkers for the detection of GC, via evaluating the correlations between their expression and clinicopathological parameters of GC *** Tissue array(n = 180) gastric specimens were utilised. IL-31, IL-32, and IL-33 expression in GC and non-GC tissues was detected immunohistochemically. The correlations between IL-31, IL-32, and IL-33 expression in GC and severity of clinicopathological parameters were evaluated. Survival curves were plotted using the Kaplan-Meier method/Cox regression. Circulating IL-31, IL-32, and IL-33 were detected by *** We found that the expression levels of IL-31, IL-32, and IL-33 were all lower in GC than in adjacent non-GC gastric tissues(P 0.05). IL-33 in peripheral blood of GC patients was significantly lower than that of healthy individuals(1.50 ± 1.11 vs 9.61 ± 8.00 ng/m L, P 0.05). Decreased IL-31, IL-32, and IL-33 in GC were observed in younger patients( 60 years), and IL-32 and IL-33 were lower in female patients(P 0.05). Higher IL-32 correlated with a longer survival in two GC subgroups: T4 invasion depth and TNM I-II stage. Univariate/multivariate analysis revealed that IL-32 was an independent prognostic factor for GC in the T4 stage subgroup. Circulating IL-33 was significantly lower in GC patients at TNM stage IV than in healthy people(P 0.05).CONCLUSION Our findings may provide new insights into the roles of IL-31, IL-32, and IL-33 in the carcinogenesis of GC and demonstrate their relative usefulness as prognostic markers for GC. The underlying mechanism of IL-31, IL-32, and IL-33 actions in GC should be further explored.