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Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo Beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： Stephanie C.Joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

Tofacitinib combined with local low-dose ixekizumab injection benefits those with peripheral psoriatic arthritis

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The Journal of Biomedical Research 2024年第1期38卷 92-94页

作者： Yours Sincerely Ruiyuan Xia Weixin Zhang Jing Hang Zhiqiang Yin Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Ultrasound the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

Dear Editor,Treating psoriatic arthritis(PsA)is always *** treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability *** injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of *** limited treatment options for PsA present a challenge.

关键词： injection drugs cavity treatment

Reliable intracavity reflection for self-injection locking lasers and microcomb generation

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Photonics Research 2024年第5期12卷 I0001-I0010页

作者： BITAO SHEN XUGUANG ZHANG YIMENG WANG ZIHAN TAO HAOWEN SHU HUAJIN CHANG WENCAN LI YAN ZHOU Zhangfeng Ge RUIXUAN CHEN BOWEN BAI LIN CHANG XINGJUN WANG State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Frontiers Science Center for Nano-optoelectronics Peking UniversityBeijing 100871China

Self-injection locking has emerged as a crucial technique for coherent optical sources,spanning from narrow linewidth lasers to the generation of localized *** technique involves key components,namely a laser diode and a high-quality cavity that induces narrow-band reflection back into the laser ***,in prior studies,the reflection mainly relied on the random intracavity Rayleigh backscattering,rendering it unpredictable and unsuitable for large-scale production and wide-band *** this work,we present a simple approach to achieve reliable intracavity reflection for self-injection locking to address this challenge by introducing a Sagnac loop into the *** method guarantees robust reflection for every resonance within a wide operational band without compromising the quality factor or adding complexity to the fabrication *** a proof of concept,we showcase the robust generation of narrow linewidth lasers and localized microcombs locked to different resonances within a normal-dispersion ***,the existence and generation of localized patterns in a normal-dispersion cavity with broadband forward–backward field coupling is first proved,as far as we know,both in simulation and in *** research offers a transformative approach to self-injection locking and holds great potential for large-scale production.

关键词： intracavity injection locking

Is intracytoplasmic sperm injection an add-on to conventional in vitro fertilisation for infertility without severe male factors?

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 105-107页

作者： Rong Li Rui Yang Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingPeople's Republic of China State Key Laboratory of Female Fertility Promotion BeijingPeople's Republic of China National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital) BeijingPeople's Republic of China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijingPeople's Republic of China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology BeijingPeople's Republic of China

Since the birth of the first in vitro fertilisation(IVF)baby in 1978,there have been over 12million babies born from IVF globally.l The first IVF baby in China's Mainland was born at Peking University Third Hospital in 1988;nowadays,more than 300000 IVF babies are born in China per *** sperm injection(ICSI)was introduced in 1992 in which conventional VF(c-IVF)had failed in severe male infertile couples(figure 1).Over the past 30 years,the use of ICSI has increased and now accounts for nearly two-thirds of IVF cycles worldwide,including 70%in Europe and North America.

关键词： injection mainland infertility

Corrigendum:Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority phase III trail

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Chronic Diseases and Translational Medicine 2024年第1期10卷 81-81页

In the article titled,“Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority ... 详细信息

关键词： injection anemia alfa

injection MOLDED TUNGSTEN HEAVY ALLOY

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中国有色金属学会会刊：英文版 1998年第4期8卷 45-50页

作者： Li Yimin, Qu Xuanhui, Li Zhilin and Huang Baiyun State Key Laboratory for Powder Metallurgy, Central South University of Technology, Changsha 410083, P. R. China State Key Laboratory for Powder Metallurgy Central South University of Technology Changsha 410083 China

ＩＮＴＲＯＤＵＣＴＩＯＮＭｅｔａｌＩｎｊｅｃｔｉｏｎＭｏｌｄｉｎｇ（ＭＩＭ），ｗｈｉｃｈｉｓｄｅｒｉｖｅｄｆｒｏｍｐｌａｓｔｉｃｉｎｊｅｃｔｉｏｎｍｏｌｄｉｎｇ，ｉｓａｋｉｎｄｏｆｎｅｗｌｙｄｅｖｅｌｏｐｅｄｐｏｗｄ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＭｅｔａｌＩｎｊｅｃｔｉｏｎＭｏｌｄｉｎｇ（ＭＩＭ），ｗｈｉｃｈｉｓｄｅｒｉｖｅｄｆｒｏｍｐｌａｓｔｉｃｉｎｊｅｃｔｉｏｎｍｏｌｄｉｎｇ，ｉｓａｋｉｎｄｏｆｎｅｗｌｙｄｅｖｅｌｏｐｅｄｐｏｗｄｅｒｍｅｔａｌｕｒｇｙｆｏｒｍｉｎ...

关键词： injection molding heavy alloy powder loading

injection molding of nano structured 90W-7Ni-3Fe alloy powder prepared by high energy ball milling

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中国有色金属学会会刊：英文版 2000年第6期10卷 794-797页

作者：范景莲曲选辉黄伯云中南工业大学粉末冶金国家重点实验室湖南长沙

Blended elemental 90W 7Ni 3Fe (mass fraction, %) powder was mechanically alloyed in a planetary ball mill. Nano crystalline grains were obtained after 10 h milling. The nano structured powder was processed to full density by metal injection molding approach. Compacts from the optimal powder binder mixture were studied for molding and sintering behaviors. Milling significantly increases the maximum powder loading and homogeneity of the feedstock, and enhances the sintering densification process. When solid state sintered at 1 350～1 450 ℃, the alloy shows very fine grains (～3 μm), high tensile strength (>1 130 MPa) and almost no distortion. [

关键词： tungsten heavy alloy nano structured powder injection molding

α-Lipoic acid improves spatial learning memory deficits induced by intracerebroventricular injection of streptozotocin via activation of JAK/STAT-GPX4 in rats

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 30-30页

作者：张瑶 Endocrinol Dept Liyuan HospTongji Med CollHuazhong Univ Sci&TechnolWuhan 430077

Objective To observe the effect of α-lipoic acid(ALA) on the intracerebroventricular injection (icv) of streptozotocin (STZ)-induced spatial learning memory impairments in rats and the underlying molecular *** Forty-... 详细信息

关键词： JAK/STAT injection STZ