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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

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Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 143-152页

作者： Wenna Li Ting Li Leilei Liu Qi Han Hairong Zhang Yike Sun Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Community Health Service Center of Hailar East Road Office Hohhotthe Inner Mongolia Autonomous Region010015China School of Medicine Henan Polytechnic UniversityJiaozuo454000China

Background: Based on the effect of seasonal changes on human visceral function, this study investigated the impact of seasonal photoperiod of the pineal body on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in rats, aiming to reveal the mechanism by which pineal gland melatonin regulates the seasonal secretion of hippocampal ***: Vernal equinox, summer solstice, autumn equinox, and winter solstice were selected as four experimental time points, and rats were randomly divided into normal control group, sham operation group, and pinealectomized group. The seasonal changes in corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH), corticosterone, hypothalamic melatonin receptor(MTR), and hippocampal corticosterone receptor(CORTR) were examined by enzyme-linked immunosorbent ***: Comparing the same group between different seasons, we showed that in the normal control group, CRH, ACTH, corticosterone, and MTR were higher, while CORTR was lower in autumn and winter than in spring(all P hypothalamic-pituitary-adrenal axis-hippocampal-receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder.

关键词： Pineal gland Melatonin Hippocampus Seasonal photoperiod hypothalamic-pituitary-adrenal axis Receptor

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Functional changes in the hypothalamic-pituitary-adrenal axis after successful cardiopulmonary resuscitation

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Emergency and Critical Care Medicine 2023年第2期3卷 46-50页

作者： Le An Zhijiang Qi Huan Shao Chunsheng Li Emergency Department of Beijing Chao-Yang Hospital Capital Medical UniversityBeijingChina

Background:Cardiac arrest(CA)is a terminal event that results in a range of pathophysiological changes in the body,most notably,systemic ischemia-reperfusion *** hypothalamic-pituitary-adrenal(HPA)axis is an important neuroendocrine system that modulates adrenocortical hormone *** study was designed to investigate the changes in HPA-related hormone levels after successful cardiopulmonary resuscitation(CPR)and to explore possible etiologies to provide a basis for relevant clinical ***:We collected the clinical data of 96 patients with CA admitted to the Emergency Department of Beijing Chaoyang Hospital,Capital Medical University,between January 2016 and May *** samples were collected 6,24,and 72 hours after restoring spontaneous circulation(ROSC).The data were compared with those of the healthy control group(n=50).An enzyme-linked immunosorbent assay(ELISA)was performed to measure copeptin,adrenocorticotropic hormone(ACTH),corticotropin-releasing hormone(CRH),and total *** data were collected for both *** the CPR group,clinical data and the end-of-study cerebral performance category(CPC)were *** were followed up through day *** or survival after day 28 was used as the study *** values were expressed as medians and quartiles or ratios(%)for statistical *** variables are expressed as mean±standard *** variables were expressed as frequencies and *** mean values of normally distributed measurement data were analyzed using 1-way analysis of variance(ANOVA)for among-group comparisons and the least significant difference(LSD)test for between-group *** v17(SPSS,Chicago,IL,USA)was used for statistical analysis,and P<0.05 was considered statistically ***:No significant between-group differences were observed in terms of age or *** 28-day mortality rate in the CPR group was 71%.ACTH and CRH levels were signific

关键词： Cardiac arrest Cardiopulmonary resuscitation Cerebral performance category hypothalamic-pituitary-adrenal axis Postcardiopulmonary resuscitation syndrome

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Inflammatory airway features and hypothalamic-pituitary- adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease

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Chinese Medical Journal 2010年第13期123卷 1720-1726页

作者： CAI Cui ZHANG Hong-ying LE Jing-jing DONG Jing-cheng CUI Yan XU Chang-qing LIU Bao-jun WU Jin-feng DUAN Xiao-hong CAO Yu-xue Lab of Integrative Medicine for Lung Inflammation and Cancers Huashan Hospital Fudan University Shanghai 200040 China

Background Bronchial asthma （BA） and chronic obstructive pulmonary disease （COPD） are both inflammatory airway diseases with different characteristics. However, there are many patients who suffer from both BA and COPD. This study was to evaluate changes of inflammatory airway features and hypothalamic-pituitary-adrenal （HPA） axis function in asthmatic rats combined with COPD. Methods Brown Norway （BN） rats were used to model These three models were compared and evaluated with the inflammatory airway diseases of BA, COPD and COPD＋BA. respect to clinical symptoms, pulmonary histopathology, airway hyperresponsiveness （AHR）, inflammatory cytokines and HPA axis function. Results The inflammatory airway features and HPA axis function in rats in the COPD＋BA model group were greatly influenced. Rats in this model group showed features of the inflammatory diseases BA and COPD. The expression of inflammatory cytokines in this model group might be up or downregulated when both disease processes are present. The levels of corticotrophin releasing hormone mRNA and corticosterone in this model group were both significantly decreased than those in the control group （P 〈0.05）. Conclusions BN rat can be used as an animal model of COPD＋BA. By evaluating this animal model we found that the features of inflammation in rats in this model group seem to be exaggerated. The HPA axis functions in rats in this model group have been disturbed or impaired, which is prominent at the hypothalamic level.

关键词： chronic obstructive pulmonary disease bronchial asthma inflammatory airway disease hypothalamic-pituitary-adrenal axis

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Shizhenqing granule stimulates the hypothalamic-pituitary-adrenal axis and reduces serum pro-inflammatory factors in a rat model with chronic eczema

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Journal of Traditional Chinese Medical Sciences 2020年第4期7卷 386-392页

作者： Jinrui Lu Xiaoyan Liu Yao Xiao Shuran Ma Department of Pharmacy Qiannan Medical College for NationalitiesDuyun558013China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming650500China Ward Two Department of NephroendocrinologyDongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective:In this study,we examined the effects of Shizhenqing granule(SZQG)on hypothalamicpituitary-adrenal(HPA)axis and serum inflammatory factors in a rat model of chronic eczema,in order to explore the mechanism of action of SZQG in treatment of this ***:Sixty SpragueeDawley male rats were randomly divided into six groups(with 10 rats per group):blank group;model group;positive control group(prednisone);and the low-,medium-,and high-dose SZQG *** for the blank group,rats in all other groups were treated with 2,4-dinitrochlorobenzene to induce chronic *** rats were administered prednisone or SZQG for 7 consecutive days after successful establishment of the chronic eczema model,and samples were collected 12 h after the last *** degree of skin lesions and the changes in serum levels of corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH),cortisol(CORT),interleukin(IL)-4,interferon(IFN)-g,IL-25,and IL-31 among the groups were ***:SZQG effectively increased the levels of CRH,ACTH,and CORT,which decreased in the serum of rats with chronic eczema,stimulated the function of the HPA axis,and promoted the expression of *** reduced the serum levels of inflammatory factors including IL-4,IL-25 and IL-31,which were overexpressed in rats with chronic eczema,and increased those of anti-inflammatory factor IFN-g,thereby alleviating the inflammatory symptoms and itching,and ameliorating the clinical symptoms of chronic ***:SZQG effectively alleviates skin lesions in the chronic eczema rat model by stimulating the function of the HPA axis.

关键词： Shizhenqing granule Chronic eczema hypothalamic-pituitary-adrenal axis Inflammatory factors

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Dampness-induced stress in rats:a novel model for exploring the disorders in hypothalamic-pituitary-adrenal axis

Dampness-induced stress in rats:a novel model for exploring ...

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第十六届中国中西医结合风湿病学术年会

作者：杨敏中国人民解放军成都军区总医院

Objective:To establish a dampness-induced model in rats for exploring the stress response and disorders in hypothalamic-pituitary-adrenal(HPA) ***:50 male Sprague Dawley(SD) rats were randomized into five groups:rats without dampness-induced stress(normal group),rats induced with medium temperature and high humility(mT-hH group),rats induced with high temperature and high humility(hT-hH group),rats induced with hT plus hH,and treated with Huangqin Huashi decoction(hT-hH-HQ group),rats induced with hT plus hH,and treated with Mifepristone(hT-hH-Mi group).The models were evaluated according to Morris water maze,open field test,pathologic observation,the expression of glucocorticoid receptor(GR),corticotropin releasing hormone(CRH),adrenocorticotropic hormone(ACTH) and corticosteroid(CORT).Results:At 6 weeks,rats in vehicle-treated groups seemed to be more damaged in HPA axis vs control,as evaluated using variables including the times into the platform,the escape latency,the rest-to-movement ratio and the times into deep rearing(Paxis.

关键词： dampness-induced stress hypothalamic-pituitary-adrenal axis Huangqin Huashi decoction

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The total flavonoids extracted from Xiaobuxin Tang reverse the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats

The total flavonoids extracted from Xiaobuxin Tang reverse t...

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两岸三地药理学与临床药理学术会议

作者： AN Lei~1 ZHANG You-zhi~2 (1. Department of Pharmacology, Dalian Medical University, Dalian 116044, China 2. Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China)

Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal (HPA) axis in chronic mild stress (CMS) model of *** Using ELISA to test the serum corticos- terone,adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) level in CMS rats;Using western blot to determine hippocampal glucocorticoids receptors (GR) expression in CMS rats. Results Co-administration of XBXT-2 (25,50 mg·kg,p.o.,28 days,the effective doses for behavioral re- sponses) significantly decreased the serum corticosterone and ACTH level in CMS rats,while the CRH level was not markedly affected by chronic stress or ***,XBXT-2 significantly increased the GR ex- pression in the hippocampus of CMS *** same effects were observed in the positive control drug imipramine (10 mg·kg,p.o.).Conclusions The decrease of serum corticosterone and ACTH level,as well as the increase of hippocampal GR expression may be the mechanisms underlying the antidepressant action of XBXT-2,which may associate with HPA axis.

关键词： Xiaobuxin-Tang hypothalamic-pituitary-adrenal axis glucocorticoid receptors stress

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Essence of"Shen(Kidney)Controlling Bones":Conceptual Analysis Based on hypothalamic-pituitary-adrenal-Osteo-Related Cells axis

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Chinese Journal of Integrative Medicine 2018年第11期24卷 806-808页

作者： XU Tao-tao JIN Hong-ting TONG Pei-jian First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou(310053)China Institute of Orthopaedicsand Traumatology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China Departmentof Orthopaedics First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China

As a traditional concept of Chinese medicine（CM）, the theory of ＂Shen（Kidney） controlling bones＂ has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal（HPA） axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis： cells that comprise bone tissue（osteo-related cells） are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.

关键词： Chinese medicine Shen (Kidney) controlling bones hypothalamic-pituitary-adrenal axis bone homeostasis osteoporosis

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Molecular chaperones in stroke-induced immunosuppression

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Neural Regeneration Research 2023年第12期18卷 2638-2644页

作者： Haoduo Qiao Qing Xu Yunfei Xu Yao Zhao Nina He Jie Tang Jie Zhao Ying Liu Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Pathophysiology Xiangya School of MedicineCentral South UniversityChangshaHunan ProvinceChina Sepsis Translational Medicine Key Laboratory of Hunan Province ChangshaHunan ProvinceChina National Medicine Functional Experimental Teaching Center ChangshaHunan ProvinceChina Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive ***-induced immunosuppression leads to increased susceptibility to post-stroke infections,such as urinary tract infections and stroke-associated pneumonia,worsening *** chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains,refolding misfolded proteins,and targeting misfolded proteins for *** molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones,cochaperones,and their associated *** review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.

关键词： Hsp70 Hsp72 Hsp90 HspB5 hypothalamic-pituitary-adrenal axis molecular chaperones neuroprotection stroke stroke-induced immunosuppression sympathetic nervous system

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Pneumocystis jiroveci pneumonia after total hip arthroplasty in a dermatomyositis patient:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3313-3320页

作者： Mao Hong Zi-Yu Zhang Xiao-Wei Sun Wei-Guo Wang Qi-Dong Zhang Wan-Shou Guo Beijing University of Chinese Medicine Beijing 100029China Department of Orthopaedic Surgery Beijing Key Lab Immune-Mediated Inflammatory DiseasesChina-Japan Friendship HospitalBeijing 100029China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100029China

BACKGROUND Pneumocystis jiroveci pneumonia(PJP)is a serious opportunistic infection that occurs mostly in patients with immunodeficiency and long-term immunosuppressive *** non-human immunodeficiency virus-infected patients,the most important risk factor for PJP is the use of glucocorticoids in combination with other immunosuppressive *** management of glucocorticoids during the perioperative period in patients with dermatomyositis requires special *** SUMMARY We report a case of PJP in the perioperative period.A 61-year-old woman with a history of anti-melanoma differentiation-associated gene 5(MDA5)-positive dermatomyositis and interstitial pneumonia was administered with long-term oral methylprednisolone and *** patient underwent right total hip arthroplasty in the orthopaedic department for bilateral osteonecrosis of the femoral *** was given intravenous drip hydrocortisone before anesthesia and on the first day after surgery and resumed oral methylprednisolone on the second postoperative *** the fifth day after surgery,the patient suddenly developed *** computed tomography scan showed diffuse grid shadows and ground glass shadows in both *** chain reaction testing of bronchoalveolar lavage fluid was positive for Pneumocystis *** patient was eventually diagnosed with PJP and was administered with oral *** the 6-mo review,there was no recurrence or *** Continued perioperative glucocorticoid use in patients with anti-MDA5-positive dermatomyositis may increase the risk of PJP.

关键词： Pneumocystis jiroveci pneumonia Glucocorticoids Perioperative period Dermatomyositis hypothalamic-pituitary-adrenal axis Case report

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