Molecular chaperones in stroke-induced immunosuppression

作     者：Haoduo Qiao Qing Xu Yunfei Xu Yao Zhao Nina He Jie Tang Jie Zhao Ying Liu Haoduo Qiao;Qing Xu;Yunfei Xu;Yao Zhao;Nina He;Jie Tang;Jie Zhao;Ying Liu

作者机构：Department of NeurosurgeryXiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of PathophysiologyXiangya School of MedicineCentral South UniversityChangshaHunan ProvinceChina Sepsis Translational Medicine Key Laboratory of Hunan ProvinceChangshaHunan ProvinceChina National Medicine Functional Experimental Teaching CenterChangshaHunan ProvinceChina Department of Clinical PharmacologyXiangya HospitalCentral South UniversityChangshaHunan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第12期

页      面：2638-2644页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：the National Natural Science Foundation of China,Nos.82172147(to YL),81571880(to YL),81373147(to YL),30901555(to JZ),30972870(to YL) the Natural Science Foundation of Hunan Province,Nos.2021JJ30900,2016JJ2157(both to YL)。 

主　　题：Hsp70 Hsp72 Hsp90 HspB5 hypothalamic-pituitary-adrenal axis molecular chaperones neuroprotection stroke stroke-induced immunosuppression sympathetic nervous system 

摘      要：Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections,such as urinary tract infections and stroke-associated pneumonia,worsening prognosis.Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains,refolding misfolded proteins,and targeting misfolded proteins for degradation.Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones,cochaperones,and their associated pathways.This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.