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Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats:a potential role of the hypothalamic-pituitary-adrenal axis

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中医杂志:英文版 2023年第5期43卷 944-954页

作者： WANG Kun ZHOU Jie CUI Shuai WU Xin ZHU Guoqi WU Shengbing ZHOU Meiqi Key Laboratory of Xin’an Medicine Ministry of EducationAnhui University of Chinese MedicineHefei 230038China Department of Acupuncture and Moxibustion the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053China Colleges of Acupuncture and Massage Anhui University of Chinese MedicineHefei 230038China Bozhou Institute of Chinese Medicine Anhui Academy of Traditional Chinese MedicineBozhou 236800China

OBJECTIVE:To verify the hypothesis that electroacupuncture inhibits the hyperactivity of the hypothalamic-pituitary-adrenal(HPA)axis via regulating the expression of glial fibrillary acidic protein(GFAP)in the hippocampus of acute myocardial ischemia(AMI)***:Sixty-six healthy male Sprague-Dawley rats were randomly divided into five groups:Sham,AMI(Model),electroacupuncture at Shenmen(HT7)-Tongli(HT5)segment(EA),non-acupoint electroacupuncture(Control),and Model+corticosterone(Model+CORT).AMI was induced via occlusion of the left anterior descending coronary artery,followed by 3 d of electroacupuncture at Shenmen(HT7)-Tongli(HT5)*** the Control group,electroacupuncture was applied at points lying 5 and 10 mm from the base of the *** AMI+CORT group was injected with CORT(20 mg/kg)in ***,electrocardiography(ECG),hematoxylin and eosin staining,and expression of glycogen phosphorylase BB(GPBB)and heart-type fatty acid-binding protein(H-FABP)were used to assess cardiac *** effects of adrenocorticotropic hormone(ACTH)and CORT were evaluated by enzymelinked immunosorbent *** expression in the Sham and Model groups were screened by tandem mass tag-based quantitative proteomics *** expression was evaluated by Western blotting(vimentin and GFAP)and immunofluorescence staining(GFAP).RESULTS:Compared with the Sham group,the hemorheology indicators,heart rate,ECG-ST segment elevation,and GPBB and H-FABP levels were higher in Model *** EA group showed reductions in these indicators compared with the Model ***,in Model rats,the expression of ACTH and CORT were significantly increased compared with the Sham *** EA group also showed reduced expression of ACTH and ***,proteomics analysis showed that vimentin was differentially expressed in Model *** with the Sham group,vimentin and GFAP expression in the hippocampus was increased in the Model group but decreased in the AM

关键词： acupuncture myocardial ischemia hippocampus vimentin glial fibrillary acidic protein hypothalamic-pituitary-adrenal

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Individual Differences in Stress Responsiveness of the hypothalamic-pituitary-adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys

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Journal of Behavioral and Brain Science 2015年第7期5卷 280-294页

作者： Nadezhda D. Goncharova Victor Yu. Marenin Tamara E. Oganyan Laboratory of Endocrinology Federal State Budgetary Scientific Institution “Research Institute of Medical Primatology” Sochi Russia

Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AVP) related disturbances of stress adaptation can occur with aging. However, most studies of such kind have been performed on rodents, give contradictory results and fail to consider individual characteristics of the animals. The purpose of this study was to investigate individual HPA responsiveness to acute stress and its vasopressinergic regulation in old female rhesus monkeys that differ in their behavioral responses to stress. Animals with depression-like or anxiety-like behavior (DAB) responded with higher plasma levels of ACTH and AVP, lower levels of corticosteroids and higher cortisol/DHEAS molar ratios to restraint stress and to insulin-induced hypoglycemia compared with animals with healthy adaptive behavior. AVP and ACTH dynamics were closely correlated in most animals. AVP treatment produced differences in HPA responses similar to those produced by the stressors. The ACTH response to hypoglycemic stress in the DAB animal with highest HPA responsiveness was dramatically reduced by prior administration of a V1b receptor antagonist. These results suggest that the dysfunctions of HPA observed in old animals with DAB are caused by increased tone of the vasopressinergic system in regulation of HPA stress reactivity.

关键词： hypothalamic-pituitary-adrenal Axis Stress Responsiveness Vasopressinergic Regulation Different Types of Adaptive Behavior Aging

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Acupuncture and Moxibustion-like thermal stimulation activate cutaneous and systematic hypothalamic-pituitary-adrenal axis in rats

Acupuncture and Moxibustion-like thermal stimulation activat...

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新时代新思维新跨越新发展——2019中国针灸学会...

作者： Wei He Ying Li XiaoNing Zhang HongYe Wan QingQuan Yu XiangHong Jing Bing Zhu Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences

Background: The skin neuroendocrine system, named as skin-brain axis plays a role in regulation of local and global homeostasis, which can be activated by physical stimulation such as Ultraviolet B(UVB). As physical treating methods, acupuncture and moxibustion often induce comprehensive responses of the body function, which assists the body in returning to homeostasis. In the present study, we investigated the response of cutaneous and systematic hypothalamic-pituitary-adrenal(HPA) axis to electroacupuncture(EA) and moxibustion like thermal stimulation. Methods: Male Sprague Dawley rats were divided into two groups: ST 36 acupoint group and LI 4 acupoint group. Rats in each group were then divided into four subgroups: Control group, Electroacupuncutre(EA) group, 37°C stimulation group,43.5°C stimulation group. Bilateral ST 36 or LI 4 acupoints were chosen as the location for EAor thermal stimulation respectively. Electroacupuncture and moxibustion-like 43.5°C thermal stimulation were delivered at bilateral ST 36 acupoints or LI 4 *** techniques were used to observe cutaneous neurohormone expression of corticotropin-releasing factor(CRF), adrenocorticotropic hormone(ACTH), and glucocorticoid receptor(GR) at the acupoints at the acupoints. Concentrations of plasma and cutaneous CRH, ACTH, Corticosterone(CORT) were determined by enzyme linked immunosorbent assay or enzyme immunoassay. Results: Immunofluorescent staining of cutaneous CRF, ACTH and GR at the acupoints showed that CRF mainly expressed in cutaneous keratinocytes, hair bulb keratinocytes, ACTH mainly expressed in cutaneous hair bulb keratinocytes(Fig. 3). GR mainly expressed in keratinocytes and hair follicles(Fig. 4).Cutaneous levels of CRF, ACTH and CORT increased(P<0.01, P<0.05, P<0.01 vs Ctrl) after EA at the ST 36 acupoints, and cutaneous levels of CORT also increased(P<0.01, vs Ctrl or37°C) after 43.5 °C thermal stimulation at the ST 36 acupoints. Cutaneous levels of CORT

关键词： Acupuncture Moxibustion hypothalamic-pituitary-adrenal skin-brain axis

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The total flavonoids extracted from Xiaobuxin Tang reverse the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats

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沈阳药科大学学报 2008年第S1期25卷 104-104页

作者： AN Lei1,ZHANG You-zhi2(1.Department of Pharmacology,Dalian Medical University,Dalian 116044,China 2.Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal(HPA)axis in chronic mild stress(CMS)model of *** Using ELISA to test the serum corticosterone,adrenocorticotropic hormone(ACTH)and corticotropin-releasing hormone(CRH)level in CMS rats;Using western blot to determine hippocampal glucocorticoids receptors(GR)expression in CMS *** Co-administration of XBXT-2(25,50 mg·kg-1,p.o.,28 days,the effective doses for behavioral responses)significantly decreased the serum corticosterone and ACTH level in CMS rats,while the CRH level was not markedly affected by chronic stress or ***,XBXT-2 significantly increased the GR expression in the hippocampus of CMS *** same effects were observed in the positive control drug imipramine(10 mg·kg-1,p.o.).Conclusions The decrease of serum corticosterone and ACTH level,as well as the increase of hippocampal GR expression may be the mechanisms underlying the antidepressant action of XBXT-2,which may associate with HPA axis.

关键词： Xiaobuxin-Tang hypothalamic-pituitary-adrenal axis glucocorticoid receptors stress

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Leptin/leptin receptor system in the regulation of reproductive functions and stress response in the European beaver

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Current Zoology 2019年第2期65卷 197-203页

作者： Katarzyna CHOJNOWSKA Joanna CZERWINSKA Tadeusz KAMINSKI Barbara KAMINSKA Aleksandra KURZYNSKA Iwona BOGACKA Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Oczapowskiego Street 1A Olsztyn 10-719 Poland

The European beaver (Castor fiber L.) is the largest free-living rode nt in Eurasia. The prese nt work aimed to determi ne sex- and seas on-related cha nges in leptin receptor (Ob-R) expression in the hypothalamic-pituitary-gonadal/adrenal axes and uterus of beavers during breeding-(April), postbreeding-(July), and pre-breeding-(November) periods. The expression of Ob-R gene and protein was found in all analyzed tissues. The expression of Ob-R mRNA remained constant in the hypothalamus of both sexes during the analyzed stages. Sex- and season-related changes were found in the pituitary gland;the greatest level was observed in July in both sexes. The same expression pattern was noted in the testis, whereas in the ovary a lack of seasonal changes was found. In uterine tissues, the greatest expression occurred in November. The impact of season was also demonstrated in the adrenal cortex. In females, a higher Ob-R transcript level was noted in April, while in males, an increased mRNA abundanee was noted in November than July. Our study suggests that in the beaver, leptin acting via the Ob-R can be an important endocrine factor engaged in the regulation of reproductive functions and stress response.

关键词： leptin receptor (Ob-R) beaver seasonal breeding hypothalamic-pituitary-gonadal axis (HPG) hypothalamic-pituitary-adrenal axis (HPA)

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Xylocarpin H, a Limonoid of <i>Xylocarpus granatum</i>, Produces Antidepressant-Like Activities in Mice

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Journal of Behavioral and Brain Science 2015年第11期5卷 524-532页

作者： Xi Yin Xin Li Yaoguang Hao Yiwen Zhao Jinghong Zhou Haishui Shi Department of Functional Region of Diagnosis Fourth Hospital of Hebei Medical University Shijiazhuang China College of Basic Medicine Hebei Medical University Shijiazhuang China Department of Biochemistry and Molecular Biology College of Basic Medicine Hebei Medical University Shijiazhuang China

Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, a limonoid of Xylocarpus granatum, has antidepressant-like effects in mouse forced swimming and tail suspension tests, two validated models of depression. 7-day oral administration of Xylocarpin H resulted in dose-dependent decreases immobility duration within the dose range of 15 - 50 mg/kg. Xylocarpin H dose-dependently increases the time spent in the central zone at doses of 5 - 50 mg/kg in locomotion activity test. In addition, 7-day treatment Xylocarpus H at 15 and 50 mg/kg doses significantly decreases levels of serum corticosterone and adrenocorticotropic hormone (ACTH) following the acute stress of forced swimming test. Furthermore, these effective doses of Xylocarpin H do not affect locomotor activity and levels of serum corticosterone and ACTH in the absence of stress. In summary, the present study, for the first time, demonstrates that Xylocarpin H exerts antidepressant-like effects in mouse behavioral models of depression, likely by inhibiting HPA axis systems. These data provide primarily basis for developing Xylocarpin H as a novel antidepressant candidate for the treatment of depression and stress related disorders.

关键词： Depression Xylocarpin H Tail Suspension Test Forced Swimming Test hypothalamic-pituitary-adrenal Axis

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Oxytocin and Stress Response

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Open Journal of Endocrine and Metabolic Diseases 2018年第3期8卷 93-104页

作者： Abeer E. Dief Elena V. Sivukhina Gustav F. Jirikowski Department of Medical Physiology University of Alexandria Alexandria Egypt Institute für Anatomie II Friedrich Schiller Universit&#228 t Jena Jena Germany

In response to a stressful unexpected experience, the brain activates a complex stress system that involves the organism in an adaptive response to the threatening situation. This stress system acts on several peripheral tissues and feeds back to the brain. One of its key players is oxytocin hormone. The neuropeptide, oxytocin (OT), has well-established roles during parturition and lactation. In addition to its peripheral actions, OT is released within multiple areas of the brain and influences behavioural and neuroendocrine responses to stress. Several studies suggest that oxytocin is implicated in the central control of responses to stress through modulation of corticotrophin releasing hormone (CRH). Intranasal OT application was associated with an inhibitory effect on adrenocorticotrophic hormone (ACTH) secretion and subsequent impairment of corticosterone secretion. This may be of importance for understanding and perhaps suggesting its utility to buffer stress. Synthesis and release of OT depend to a great extent on steroid hormones particularly on estradiol and corticosterone. Estrogens stimulate synthesis and release of OT and increase the number of OT receptors in some areas of the brain. However, the role of OT in mediating stress is variable and may also depend on gender and on external factors.

关键词： Oxytocin Central Stress Response Corticotrophin Releasing Hormone Steroid Hormone hypothalamic-pituitary-adrenal Axis

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Is perinatal neuroendocrine programming involved in the developmental origins of metabolic disorders?

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World Journal of Diabetes 2011年第12期2卷 211-216页

作者： David IW Phillips Stephen G Matthews MRC Lifecourse Epidemiology Unit South-ampton General Hospital Department of Physiology Faculty of Medicine University of Toronto Medical Sciences Building 1 King's College Circle

The discovery that small size at birth and during infancy are associated with a higher risk of diabetes and related metabolic disease in later life has pointed to the importance of developmental factors in these conditions. The birth size associations are thought to refl ect exposure to adverse environmental factors during early development but the mechanisms involved are still not fully understood. Animal and human work has pointed to the importance of changes in the setpoint of a number of key hormonal systems controlling growth and development. These include the IGF-1/GH axis, gonadal hormones and, in particular, the systems mediating the classical stress response. Several studies show that small size at birth is linked with increased activity of the hypothalamic-pituitary-adrenal axis and sympathoadrenal system in adult life. More recent human studies have shown associations between specif ic adverse experiences during pregnancy, such as famine or the consumption of adverse diets, and enhanced stress responses many decades later. The mediators of these neuroendocrine responses are biologically potent and are likely to have a direct infl uence on the risk of metabolic disease. These neuroendocrine changes may also have an evolutionary basis being part of broader process, termed phenotypic plasticity, by which adverse environmental cues experienced during development modify the structure and physiology of the adult towards a phenotype adapted for adversity. The changes are clearly advantageous if they lead to a phenotype which is well-adapted for the adult environment, but may lead to disease if there is subsequent overnutrition or other unexpected environmental conditions.

关键词： Neuroendocrine fetal programming Metabolic disease Diabetes hypothalamic-pituitary-adrenal axis Stress responses Birth weight

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