The total flavonoids extracted from Xiaobuxin Tang reverse the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats

作     者：AN Lei1,ZHANG You-zhi2(1.Department of Pharmacology,Dalian Medical University,Dalian 116044,China 2.Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China) 

出 版 物：《沈阳药科大学学报》 (Journal of Shenyang Pharmaceutical University)

年 卷 期：2008年第25卷第S1期

页      面：104-104页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Xiaobuxin-Tang hypothalamic-pituitary-adrenal axis glucocorticoid receptors stress 

摘      要：Objective To investigate the effect of XBXT-2 on the activity of hypothalamic-pituitary-adrenal(HPA)axis in chronic mild stress(CMS)model of *** Using ELISA to test the serum corticosterone,adrenocorticotropic hormone(ACTH)and corticotropin-releasing hormone(CRH)level in CMS rats;Using western blot to determine hippocampal glucocorticoids receptors(GR)expression in CMS *** Co-administration of XBXT-2(25,50 mg·kg-1,p.o.,28 days,the effective doses for behavioral responses)significantly decreased the serum corticosterone and ACTH level in CMS rats,while the CRH level was not markedly affected by chronic stress or ***,XBXT-2 significantly increased the GR expression in the hippocampus of CMS *** same effects were observed in the positive control drug imipramine(10 mg·kg-1,p.o.).Conclusions The decrease of serum corticosterone and ACTH level,as well as the increase of hippocampal GR expression may be the mechanisms underlying the antidepressant action of XBXT-2,which may associate with HPA axis.