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Chinese Journal of Traumatology 2006年第3期9卷 168-174页

作者：刘展焦庆芳游潮车彦军苏芳忠 Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Department of Neurosurgery Second affiliated HospitalZhengzhou UniversityZhengzhou 450014China

Objective： To explore the effects of hyperbaric oxygen （HBO） treatment on the neuronal apoptosis at an earlier stage and the expressions of Cytochrome C （Cyt C）, Bcl-2 （B-cell lymphoma-2 family） and Bax （Bcl-2 associated X protein） in rat brain tissues after traumatic brain injury （TBI）. Methods： Forty adult rats were divided into two groups, i.e. ,Group A （the rats with untreated TBI） and Group B （ rats with HBO treatment after TBI）. Sections of brain tissues of these two groups were then detected at 3,6, 12,24,72 hours after TBI by immunohistochemistry and Results： HBO treatment could up-regulate the expression of Bcl-2 within 72 hours, reduce the release of Cyt C from mitochondria, attenuate the formation of dimeric Bax and alleviate the mitochondrial edema within 24 hours after TBI. Conclusions： HBO treatment can alleviate neuronal apoptosis after TBI by reducing the release of Cyt C and the dimers of Bax and up-regulating the expression of Bcl-2.

关键词： hyperbaric oxygen Apoptosis Cytochrome C Bcl-2 associated X protein

Structural changes of neurons in hippocampus from infantile rats exposed to hyperbaric oxygen

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Chinese Journal of Traumatology 2000年第4期3卷 206-209页

作者：刘燕鲍锦华赖晃文杨传红冯晓冬李建军 Department of hyperbaric oxygen Guangzhou General Hospital of Guangzhou Military Area

To investigate if hyperbaric oxygen (HBO) may induce structural changes of neurons in hippocampus from infantile rats and if the changes are reversible. Methods: All 27 healthy SD infantile rats were exposed to HBO ( 0.25 MPa) or hyperbaric air (HBA) for 1 to 3 courses (10 days as 1 course). The hippocampus was taken at the end of each course to observe its morphology by light microscope and electron microscope. Results: HBO exposure induced capillary dilation, nuclear membrane winding or blurring and some mitochondria swelling with its crista blurring in neurons. The changes occurred after 1 course exposure and became significant with time. Most of the changes recovered 20 days after stopping exposure. No change was found after HBA exposure. Conclusions: Long-term HBO exposure can cause capillary dilation and ultrastructural injury of neurons in hippocampus from infantile rats. The damage is not serious, but reversible.

关键词： Hippocampus Neuron Structure hyperbaric oxygen

Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury

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Plastic and Aesthetic Research 2015年第1期2卷 332-339页

作者： Yi-Ding Xiao Yun-Qi Liu Ming-Zi Zhang You-Bin Wang Yi-Fang Liu Xue-Mei Ma Department of Plastic Surgery Peking Union Medical College HospitalDongcheng 100730BeijingChina College of Life Science and Bioengineering Beijing University of TechnologyChaoyang 100124BeijingChina

Aim:This study was conducted to evaluate the synergistic effects of hyperbaric oxygen(HBO)preconditioning and hydrogen-rich saline(HRS)treatment on skin flap survival and apoptosis in a rat ischemia/reperfusion(IR)skin flap ***:Male Sprague-Dawley rats were randomly divided into five groups:one sham surgery group(sham group)and four surgery groups(IR group,HBO group,HRS group,and HBO+HRS group).An extended epigastric adipocutaneous flap(6 cm×9 cm)was raised over the abdomen in each animal of all five *** last four groups underwent 6 h of IR management and were treated,respectively,with normal saline,HBO,HRS(HRS,0.8 mmol/L),or a combined approach(HBO and HRS).On the 3rd postoperative day,flap survival rate and perfusion condition,apoptotic index,caspase-3 activity,protein expression of pASK1 and Bcl-2/Bax ratio,and Bcl-2 messenger RNA(mRNA)expression were ***:Prior studies have shown the protective effects of HBO and HRS,both of which have been associated with an increase in flap *** to the IR group,the flaps in the HBO,HRS,and HBO+HRS groups showed better perfusion and a larger survival area with a low number of apoptotic cells,low caspase-3 activity and pASK1 expression,and a high Bcl-2/Bax ratio and Bcl-2 mRNA *** these groups,the HBO+HRS group showed the best flap ***:Both HBO and HRS treatments increase the rate of flap survival,while the synergistic application of HBO and HRS showed a higher survival rate as compared to individual treatments of *** potential regulation of apoptosis with the use of these two modalities may improve skin flap survival.

关键词： Apoptosis hydrogen‑rich saline hyperbaric oxygen ischemia/reperfusion injury skin flaps

The Effect of Different hyperbaric oxygen Treatment Time Windows on Neurological Function and Prognosis in Acute Cerebral Infarction

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Expert Review of Chinese Medical

Expert Review of Chinese Medical 2024年第2期2卷 1-6页

作者： Tianqi Chen Xiaobei Liu Hubei University of Arts and Sciences Affiliated Hospital Xiangyang Central Hospital The First Clinical Medical College of Mudanjiang Medical College

Objective:To observe the effects of different hyperbaric oxygen treatment time windows on the prognosis and neurological function of acute cerebral ***:160 patients with acute cerebral infarction admitted to Xiangyang Central Hospital in Hubei Province were randomly divided into four groups,each with 40 cases,using a random number table *** to the 2017 guidelines for the treatment of cerebral infarction,the control group received routine treatment for acute cerebral infarction;On the basis of the control group,patients in Group A received hyperbaric oxygen therapy within 48 hours of onset;Group B patients receive hyperbaric oxygen therapy within 3-6 days of onset;Group C patients receive hyperbaric oxygen therapy within 7-12 days of *** the efficacy,recurrence,and neurological function recovery of four groups of patients after ***:There was no statistically significant difference in the National Institutes of Health Stroke Scale(NIHSS)and Barthel Index(BI)scores among the four groups before treatment(P>0.05).There were statistically significant differences in NIHSS and BI scores between 14 and 30 days after treatment and before treatment(F=16.352,27.261,11.899,28.326,P0.05).After 30 days of treatment,the total effective rate of Group A was higher than that of the control group and Group C,and the difference was statistically significant(X2=6.135,P<0.05).The one-year recurrence rate of Group A and Group B is lower than that of Group C and the control group,and the difference is statistically significant(X2=8.331,P<0.05).There was no statistically sign

关键词： acute cerebral infarction neurological function hyperbaric oxygen recrudescence

The Clinical Effects of hyperbaric oxygen in the Treatment of Sudden Deafness

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Journal of Clinical and Nursing Research 2021年第4期5卷 242-245页

作者： Xinli Feng Ying Chang hyperbaric oxygen Treatment Room Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Gastroenterology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To observe the clinical effect of hyperbaric oxygen in the treatment of sudden ***:Ninety-six patients with sudden deafness diagnosed by the otolaryngology department were divided into 2 groups which comprised of 48 patients in the conventional treatment group and the other 48 patients in the hyperbaric oxygen treatment *** groups were treated with methylcobalamin,vitamin B1,and ginkgo biloba *** patients in the hyperbaric oxygen treatment group were given hyperbaric oxygen therapy of 2.0 ATA once a *** course of treatment lasted 10 days and after two courses of treatment,the clinical efficacies of the two groups were ***:After two courses of treatment,the effect of treatment in the hyperbaric oxygen treatment group was significantly better than that of the conventional treatment ***:hyperbaric oxygen therapy can effectively improve the hearing level of patients with sudden deafness and the overall effective rate of treatment.

关键词： Sudden deafness hyperbaric oxygen Clinical effect

Therapeutic Effect of hyperbaric oxygen on Experimental Piglet Hypoxic-Ischemic Brain Damage

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中国当代儿科杂志 2001年第4期 446-449页

作者： BO Tao, HAN Yu-Kun, SHU HangDepartment of Pediatrics, Second Clinical Hospital, China Medical University, Shenyang 110003, China

Objective To investigate the therapeutic effect of hyperbaric oxygen (HBO) on experimental piglet hypoxic-ischemic brain damage (HIBD) and its protective mechanism by using piglets as the animal model for HIBD in newborns. Methods Using Levine’s method, thirty 7-day-old HIBD piglets were randomly divided into the control group and the HBO-treated group in which the piglets were treated with HBO for 3 hours daily. Half of the piglets in each group were sacrificed on the 1st and 7th day after hypoxic-ischemic (HI) injury respectively. For these two groups, we observed (1) the mortality and neurological symptoms; (2) the velocity of blood flow in the right carotid artery (rVCA); (3) the brain weight; (4) the quantitative analysis of subdiploid cells in the brain by flow cytometry. Results The mortality and the incidence of neurological symptoms in the HBO-treated group were less than those in the control group (P 0.05). The rVCA in the HBO-treated group was faster significantly than that in the control group when the first HBO therapy ended [( 146.8± 16.8) ml/min vs ( 123.9± 27.6) ml/min](P< 0.01). The ratio of subdiploid cells to all cells in the HBO group was less than that in the control group in the bilateral hippocampus on the 1st and 7th day after HI, and in the left frontoparietal cortex on the 1st day after HI. Conclusions HBO therapy is effective on HIBD, and should be recommended as a short-term and early treatment.

关键词： hyperbaric oxygen Brain hypoxia Brain ischemia Newborn Piglet

The responses of rat carotid body to IL-1β,chronic intermittent hypobaric and hyperbaric oxygen stimuli

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The responses of rat carotid body to IL-1β,chronic intermit...

hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia in rabbits

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Zheng-Wu PENG~(1,2),Hui-Ying ZHAO~2,Juan FAN~1,Ling LIU~1,Xi WANG~1,Bai-Ren WANG~(1,*) 1 Institute of neurosciences,Fourth Military Medical University,Xi’an 710032,China 2 College of Veterinary Medicine,Northwest A&F Universty,Yangling 712100,China

Objective The carotid body(CB) is a well characterized chemoreceptive organ that senses PaO,PaCO,acidity and glucose concentration in arterial *** previous studies we reported stimulation of proinflammatory cytokines can also induce changes of cellular activity in CB principal cells and increase the discharge rate in carotid sinus *** researches have indicated that the CB supporting cells have stem cell potentiality and these progenitors are able to produce clonal colonies easily,self-renew,and differentiate into multiple cell types in *** oxygen(HBO) has conspicuous curative effect to carbon monoxide poisoning and ischemia reperfusion injury in *** present study, the effect of chronic intermittent hypobaric oxygen(CIHO),hyperbaric oxygen(HBO) and exogenous IL-1βon the expressions of growth associated protein(GAP)-43,nestin and phosphorylated protein kinase C(pPKC)-γwere investigated in the *** The rats in IL-1βgroup were subjected to an intraperitoneal injection of rmIL-1β(1μg/kg) once a day for 3 consecutive *** in CIHO group were put in hypobaric oxygen cabin(PB=375 Torr and oxygen pressure was 10%) for lOh a day for 1,2 or 3 weeks,*** in HBO group received Id or consecutive 5 d,10 d and 20 d of HBO(2.5 ATA,100%02,1h/d).Rats in hyperbaric group received same treatment as HBO group except that the oxygen pressure was 20%.The rats without any treatment or only received saline injection were served as control. Immunohistochemistry and Western blotting techniques used to judge the above protein expression in *** GAP-43 was expressed in both principal and supporting cells as well as in nerve fibers in normal *** no nestin-expressing cells were found in normal ***-γwas expressed in the some glomus cells of normal *** expressions of GAP-43,nestin and pPKC-γwere up-regulated by CIHO and IL-1βinjection but decreased by HBO in time-dependent *** treatment with normal ox

关键词： Carotid body IL-1β chronic hypoxia hyperbaric oxygen PKC-γ Rat

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中国临床神经科学 2000年第Z1期8卷 77-页

作者： DONG Hai-Long XIONG Li-Ze ZHU Zheng-Hua Department of Anesthesiology Xijing Hospital Xi' an 710033 Shannxi Province China Department of Anesthesiology Xijing Hospital Xi' an 710033 Shannxi Province China Department of Anesthesiology Xijing Hospital Xi' an 710033 Shannxi Province China

Objective To determine whether the ischemic tolerance could be induced in the spinal cord by pretreated with hyperbaric oxygen (HBO). Methods 23 New Zealand white rabbits(2. 1 ±0.3Kg) were randomly assigned to three groups. Control Group: n=8,no hyperbaric oxygen was applied before spinal cord ischemia; HBO-1 Group: n=8,hyperbaric oxygen (2.5ATA, 100% O2, 1 hr per day) pretreated for 3 days before ischemia; HBO-2 Group: n=7, hyperbaric oxygen pretreated for 5 days before ischemia. Infrarenal aorta clamping modal was used in this study. Ischemia lasted for 20-min. MAP(proximal Distal)- HR、 PaO2、 PaCO2、 pH、 rectal temperature and plasma glucose were measured during experiment. Results The neurologic outcome both in HBO-1 and HE-2 Groups were better than that of Control Group (P＜0.05). The neruologic outcome in HBO-2 was better than that of HBO-1 Group (P＜0.05). The normal neurons in the anterior spinal cord of HBO-2 Group were more than that of Control and HBO-1 *** number of normal neurons in the anterior spinal cord of HBO-1 Group was similar with that of Control Group. Conclusion hyperbaric oxygen preconditioning could induce ischemic tolerance on spinal cord in rabbits. 5 days period of HBO preconditioning induce stronger ischemic tolerance than 3 days of HBO preconditioning.

关键词： hyperbaric oxygen spinal cord ischemia used in

Therapeutic Effect Observation on Treatment of Craniocerebral Trauma-Related Coma with Acupuncture plus hyperbaric oxygen:A Report of 45 Cases

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Journal of Acupuncture and Tuina Science 2006年第5期4卷 303-304页

作者：刘朝生周晖唐晓萍刘芳韩丑萍(Translator) The physiotherapy department No 163 PLA Hospital Changsha 410003 P. R. China 不详

Objective： To investigate the efficacy of treating craniocerebral trauma-related coma with acupuncture plus hyperbaric oxygen. Methods： Coma patients were randomly allocated into observation and control groups. Routine surgery or non-surgical treatment was given according to the condition of injury. The observation group received acupuncture plus hyperbaric oxygen as well as the treatment for the control group. The score was counted by the Glasgow coma scale before and after the treatment. A chi-square test was used. Results： There was a very significant difference in curative effect between the observation and control groups （P〈0.01）. Conclusion： Treatment with acupuncture plus hyperbaric oxygen can promote the patients＇ early revival.

关键词： Coma Acupuncture Therapy hyperbaric oxygen

Observation on Therapeutic Effect in Treatment of Hypoxemic Infantile Encephalopathy by Acupuncture plus hyperbaric oxygen

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Journal of Acupuncture and Tuina Science 2006年第5期4卷 293-295页

作者：刘锦郭峰蒯乐 (Translator) Department of physiotherapy Lanzhou general hospital of Lanzhou military area Lanzhou 730050 P. R. China 不详

Objective： To investigate the therapeutic effect of acupuncture plus hyperbaric oxygen in treating hypoxemic infantile encephalopathy （HIE）. Methods： Fifty-nine HIE children were divided into treatment （33 cases） and control （26 cases） groups. Both groups were treated by basic therapy of removing acidosis, controlling cerebral edema and convulsion, and intravenous drip of cerebrolysin or citicoline. The treatment group was treated by acupuncture plus hyperbaric oxygen and the control group was treated by hyperbaric oxygen only. Results： The total effective rate was 97.0% in the treatment group and 73.1% in the control group. Statistical analysis showed a highly significant difference （P〈0.01）. Conclusion： Acupuncture plus hyperbaric oxygen was better than simple hyperbaric oxygen in treating HIE. Its main manifestations were shortening the course of disease, increasing cure rate, decreasing death rate and reducing the occurrence of sequelae. HIE children should be treated as early as possible.

关键词： Acupuncture Hypoxemic Encephalopathy hyperbaric oxygen