检索结果-南通市图书馆

Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes

Maternal-Fetal Medicine 2023年第3期5卷 163-172页

作者： Jiasong Cao Yixin Wang Shuqi Wang Yongmei Shen Wen Li Zhuo Weil Shanshan Li Qimei Lin Ying Chang Tianjin Key Laboratory of Human Development and Reproductive Regulation Tianjin Central Hospital of Gynecology Obstetrics and Nankai University Affiliated Hospital of Obstetrics and GynecologyTianjin 300100China School of Clinical Medicine Tianjin Medical UniversityTianjin 300070China

Steroid hormones,including progestagens,estrogens,androgens,corticosteroids,and their precursor cholesterol,perform essential functions in the successful establishment and maintenance of pregnancy and normal fetal *** the core endocrine organ at the prenatal stage,the human placenta is involved in the biosynthesis,metabolism,and delivery of steroid *** pathways are tightly regulated by placenta-intrinsic cytochrome P450 and hydroxysteroid ***,the relationship between placental steroidogenic enzyme expression and adverse pregnancy outcomes is *** this review,we summarize the possible upstream regulatory mechanisms of placental steroidogenic enzymes in physiologic and pathophysiologic *** also describe the human placental barrier model and examine the potential of single-cell sequencing for evaluating the primary functions and cellular origin of steroidogenic ***,we examine the existing evidence for the association between placental steroidogenic enzyme dysregulation and adverse pregnancy outcomes.

关键词： Placenta Steroidogenic enzymes Maternal-fetal outcomes Cytochrome P450 hydroxysteroid dehydrogenase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary-testicular axis secretion in aging rats

引用

Neural Regeneration Research 2012年第21期7卷 1611-1617页

作者： Siyun Niu Suru Kou Xiaochun Zhou Liang Ding School of Basic Medical Science Hebei University Baoding 071000 Hebei Province China Institute of Basic Medical Sciences Chengde Medical College Chengde 067000 Hebei Province China

An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction （a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Epimedii, Radix Salviae Miltiorrhiae, and Poria）. Heshouwu pill treated rats were the positive control group. Radioimmunoassay, immunohistochemical staining, and western blot assay showed hypothalamic gonadotropin-releasing hormone, hypothalamic substance P, and serum gonadotropin levels to be significantly increased in the model rats; the concentrations of hypothalamic ~3-endorphin, and serum levels of insulin-like growth factor I and testosterone were significantly decreased. 1713- and 3[3-hydroxysteroid dehydrogenase expression in testicular tissue was also decreased. Intragastric administration of Heshouwu decoction at high （9.6 g/mL/100 g）, medium （4.8 g/mL/100 g）, and low （2.4 g/mlJ100 g） doses, Heshouwu decoction pretreatment at a medium dose （4.8 g/mL/100 g）, and Heshouwu pill （2.06 g/mL/100 g） significantly reversed these changes. Heshouwu decoction pretreatment and high-dose Heshouwu decoction had the greatest anti-aging effects. These experimental findings indicate that Heshouwu decoction can improve hypothalamic-pituitary-testicular axis secretion in a subacute aging rat model, and prevent and delay gonadal axis aging, with an effect superior to that of Heshouwu pill.

关键词： Heshouwu decoction pituitary gonadal axis aging gonadotropin-releasing hormone gonadotropin hydroxysteroid dehydrogenase hypothalamic-pituitary-testicular axis neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of noise exposure(85 dB) on testicular adrenocortical steroidogenic key enzymes, acid and alkaline phosphatase activities of sex organs in mature albino rats

引用

Journal of Environmental Sciences 2000年第3期12卷 286-289页

作者： Debidas Ghosh, Sampa Ghosh, Sandip Chattopadhyay, Jogen Debnath (Department of Human Physiology with Community Health, Vidyasagar University, Midnapore\|721 102, West Bengal, India) Department of Human Physiology with Community Health Vidyasagar University Midnapore-721 102 West Bengal India

Changes in the activities of Δ 5\|3β\|hydroysteroid dehydrogenase(HSD) in testis and adrenal gland, 17β\|hydroxysteroid dehydrogenase in testis, acid and alkaline phosphatase in testis, prostate and seminal vesicle were observed in noise exposed mature rats at the intensity of 85 dB for 8 h/day for 45 days. The results indicated that noise exposed group showed a significant diminution in the activities of androgenic key enzymes Δ 5\|3β and 17β\|HSD, acid phosphatase in testis, prostate and seminal vesicle. There was a significant elevation in the activities of adrenal Δ 5\|3β\|HSD, alkaline phosphatase in testis and other accessory sex organ in noise exposed group. Gonadosomatic, prostatosomatic and seminal vesiculo\|somatic indexes were decreased significantly in noise exposed group. Therefore, it is evident that noise exposure at 85dB exerts a deleterious effect on testicular and adrenocortical activities.

关键词： noise hydroxysteroid dehydrogenase acid phosphatase alkaline phosphatase sex organs adrenal cortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：