Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes

作     者：Jiasong Cao Yixin Wang Shuqi Wang Yongmei Shen Wen Li Zhuo Weil Shanshan Li Qimei Lin Ying Chang 

作者机构：Tianjin Key Laboratory of Human Development and Reproductive RegulationTianjin Central Hospital of Gynecology Obstetrics and Nankai University Affiliated Hospital of Obstetrics and GynecologyTianjin 300100China School of Clinical MedicineTianjin Medical UniversityTianjin 300070China 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2023年第5卷第3期

页      面：163-172页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grants from the Natural Science Foundation of Tianjin,China(20JCYBJC01400 to Y.C.and 21JCYBJC00100 to J.S.C.) Open Project of Tianjin Key Laboratory of Human Development and Reproductive Regulation(2021XH05 to J.S.C.) 

主　　题：Placenta Steroidogenic enzymes Maternal-fetal outcomes Cytochrome P450 Hydroxysteroid dehydrogenase 

摘      要：Steroid hormones,including progestagens,estrogens,androgens,corticosteroids,and their precursor cholesterol,perform essential functions in the successful establishment and maintenance of pregnancy and normal fetal *** the core endocrine organ at the prenatal stage,the human placenta is involved in the biosynthesis,metabolism,and delivery of steroid *** pathways are tightly regulated by placenta-intrinsic cytochrome P450 and hydroxysteroid ***,the relationship between placental steroidogenic enzyme expression and adverse pregnancy outcomes is *** this review,we summarize the possible upstream regulatory mechanisms of placental steroidogenic enzymes in physiologic and pathophysiologic *** also describe the human placental barrier model and examine the potential of single-cell sequencing for evaluating the primary functions and cellular origin of steroidogenic ***,we examine the existing evidence for the association between placental steroidogenic enzyme dysregulation and adverse pregnancy outcomes.