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Wear Behavior of PTFE–hydroxyapatite composite Fabricated by Hot-Press Sintering Process

Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 347-351页

作者： H.R.Zafarani M.Abdi M.E.Bahrololoom Department of Materials Science and Engineering School of EngineeringShiraz University

In the present work, a new biocompatible composite was fabricated by hot-press sinter-bonding of polytet- rafluoroethylene （PTFE）-hydroxyapatite composite. Furthermore, the wear properties of this composite were studied by computer-controlled pin-on-disk type tribometer in reporting volume loss per distance. The investigation was performed in three different fractions of hydroxyapatite （10, 20 and 30 wt%）. In order to improve the bonding between hydroxyapatite and PTFE, and thus to increase the wear properties of the composite, the effect of adding silane-coupling agent was investigated. Furthermore, to simulate the environment of human body, some of the wear tests were carried out in the ringer＇s solution. It was found that the wear resistance is improved at high load. Moreover, an optimum fraction of hydroxyapatite （20 wt%） was found in which the best wear resistance is achieved, especially at dry sliding condition. At last, the roles of the factors such as wear load, ringer＇s solution, and silane-coupling agent are described with respect to their influences on the Lancaster wear coefficient.

关键词： hydroxyapatite composite Polymers Silane-coupling agent Wear resistance

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An in-vitro Investigation of Iron-Containing hydroxyapatite/Titanium composites

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Journal of Materials Science & Technology 2011年第6期27卷 546-552页

作者： Q. Chang H.Q. Ru D.L. Chen X.Y. Yue L. Yu C.P. Zhang Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University Shenyang 110004 China Department of Mechanical and Industrial Engineering Ryerson University 350 Victoria Street Toronto Ontario M5B 2K3 Canada

The in-vitro biological behavior of a newly-developed iron-containing hydroxyapatite/titanium（HA/Ti） composite was investigated by immersing the composites in the simulated body fluid（SBF） for up to 5 *** addition of iron was observed to have a significant influence on the in-vitro biological behavior of the *** obtained results revealed that the stability of the composites in the physiological solution was markedly *** solubility decreased in the order of pure HA,HA/5（Ti-33Fe）,and HA/15（Ti33Fe）.Precipitation occurred on the surface of HA/5（Ti-33Fe） composite,showing a good combination of physiostability with bioactivity,while HA/15（Ti-33Fe） composite exhibited superior physiostability since there was no obvious change on the surface of HA/15（Ti-33Fe）.

关键词： hydroxyapatite composite Iron Titanium Simulated body fluid Biological behavior

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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

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Journal of Pharmaceutical Analysis 2021年第3期11卷 364-373页

作者： Monika Zielinska Ewa Chmielewska Tomasz Buchwald Adam Voelkel PawełKafarski Poznan University of Technology Institute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and Technology Faculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of Technology Institute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland

There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.

关键词： Monolithic column Polymer composites Bisphosphonates hydroxyapatite coatings hydroxyapatite composite

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