Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

作     者：Monika Zielinska Ewa Chmielewska Tomasz Buchwald Adam Voelkel PawełKafarski Monika Zieli(n)ska;Ewa Chmielewska;Tomasz Buchwald;Adam Voelkel;Pawe(l) Kafarski

作者机构：Poznan University of TechnologyInstitute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and TechnologyFaculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of TechnologyInstitute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2021年第11卷第3期

页      面：364-373页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0817[工学-化学工程与技术] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：supported by the Ministry of Science and Higher Education grants and subsidy of the Ministry of Science and Higher Education 

主　　题：Monolithic column Polymer composites Bisphosphonates Hydroxyapatite coatings Hydroxyapatite composite 

摘      要：There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.