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Urinary Creatinine Concentrations and Its Explanatory Variables in General Chinese Population:Implications for Creatinine Limits and Creatinine Adjustment

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Biomedical and Environmental Sciences 2022年第10期35卷 899-910页

作者： JI Sai Sai LYU Yue Bin QU Ying Li HU Xiao Jian LU Yi Fu CAI Jun Fang SONG Shi Xun ZHANG Xu LIU Ying Chun YANG Yan Wei ZHANG Wen Li LI Ya Wei ZHANG Ming Yuan CHEN Chen LI Cheng Cheng LI Zheng GU Heng LIU Ling CAI Jia Yi QIU Tian FU Hui JI S.John ZHAO Feng ZHU Ying CAO Zhao Jin SHI Xiao Ming China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China School of Public Health Jilin UniversityChangchun 130021JilinChina Vanke School of Public Health Tsinghua UniversityBeijing 100084China

Objective The study aimed to analyze the applicability of the World Health Organization’s exclusionary guidelines for Urinary creatinine(Ucr)in the general Chinese population,and to identify Ucr related *** We conduct a cross-sectional study using baseline data from 21,167 participants in the China National Human Biomonitoring *** linear models and restricted cubic splines(RCS)were used to analyze the associations between explanatory variables and Ucr *** The geometric mean and median concentrations of Ucr in the general Chinese population were 0.90 g/L and 1.01 g/L,*** 9.36%samples were outside 0.3-3.0 g/L,including 7.83%below the lower limit and 1.53%above the upper *** age,male,obesity,smoking,higher frequency of red meat consumption and chronic kidney disease were associated significantly with higher concentrations of *** of the RCS showed Ucr was positively and linearly associated with body mass index,inversely and linearly associated with systolic blood pressure,diastolic blood pressure,triglycerides level,and glomerular filtration rate,and were non-linearly associated with *** The age-and gender-specific cut-off values of Ucr that determine the validity of urine samples in the general Chinese population were *** avoid introducing bias into epidemiologic associations,the potential predictors of Ucr observed in the current study should be considered when using Ucr to adjust for variations in urine dilution.

关键词： Biomonitoring Urine hydration correction Creatinine

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