Urinary Creatinine Concentrations and Its Explanatory Variables in General Chinese Population:Implications for Creatinine Limits and Creatinine Adjustment

作     者：JI Sai Sai LYU Yue Bin QU Ying Li HU Xiao Jian LU Yi Fu CAI Jun Fang SONG Shi Xun ZHANG Xu LIU Ying Chun YANG Yan Wei ZHANG Wen Li LI Ya Wei ZHANG Ming Yuan CHEN Chen LI Cheng Cheng LI Zheng GU Heng LIU Ling CAI Jia Yi QIU Tian FU Hui JI S.John ZHAO Feng ZHU Ying CAO Zhao Jin SHI Xiao Ming JI Sai Sai;LYU Yue Bin;QU Ying Li;HU Xiao Jian;LU Yi Fu;CAI Jun Fang;SONG Shi Xun;ZHANG Xu;LIU Ying Chun;YANG Yan Wei;ZHANG Wen Li;LI Ya Wei;ZHANG Ming Yuan;CHEN Chen;LI Cheng Cheng;LI Zheng;GU Heng;LIU Ling;CAI Jia Yi;QIU Tian;FU Hui;JI S.John;ZHAO Feng;ZHU Ying;CAO Zhao Jin;SHI Xiao Ming

作者机构：China CDC Key Laboratory of Environment and Population HealthNational Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China School of Public HealthJilin UniversityChangchun 130021JilinChina Vanke School of Public HealthTsinghua UniversityBeijing 100084China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2022年第35卷第10期

页      面：899-910页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：supported by the National Health Commission Public Health Special Program of China[grant number:131031108000160004] 

主　　题：Biomonitoring Urine Hydration correction Creatinine 

摘      要：Objective The study aimed to analyze the applicability of the World Health Organization’s exclusionary guidelines for Urinary creatinine(Ucr)in the general Chinese population,and to identify Ucr related *** We conduct a cross-sectional study using baseline data from 21,167 participants in the China National Human Biomonitoring *** linear models and restricted cubic splines(RCS)were used to analyze the associations between explanatory variables and Ucr *** The geometric mean and median concentrations of Ucr in the general Chinese population were 0.90 g/L and 1.01 g/L,*** 9.36%samples were outside 0.3-3.0 g/L,including 7.83%below the lower limit and 1.53%above the upper *** age,male,obesity,smoking,higher frequency of red meat consumption and chronic kidney disease were associated significantly with higher concentrations of *** of the RCS showed Ucr was positively and linearly associated with body mass index,inversely and linearly associated with systolic blood pressure,diastolic blood pressure,triglycerides level,and glomerular filtration rate,and were non-linearly associated with *** The age-and gender-specific cut-off values of Ucr that determine the validity of urine samples in the general Chinese population were *** avoid introducing bias into epidemiologic associations,the potential predictors of Ucr observed in the current study should be considered when using Ucr to adjust for variations in urine dilution.