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huoxue tongjiang decoction-resisted reflux esophagitis by activation stem cell factor/c-kit/interstitial cell of cajal pathway and regulating the T-helper 17/regulatory T-cells balance in rats

引用

Traditional Medicine Research 2024年第12期9卷 1-12页

作者： Yan Liu Yan-Ping Tang Pei-Cai Li Lei Liu Xi Liu Si-Yu Liu Lei Yang Division of Gastroenterology Hospital of Integrated Chinese and Western MedicineTianjin University of Traditional Chinese MedicineTianjin 300000China Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair Hospital of Integrated Chinese and Western MedicineTianjin 300000China Institute of Integrative Medicine for Acute Abdominal Diseases Hospital of Integrated Chinese and Western MedicineTianjin 300000China

Background:huoxue tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE ***:Chemical composition of HXTJD was analyzed by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry(MS).The change rates of mean contraction tension forces,mean amplitudes,and mean frequencies for the lower esophageal sphincter(LES)were recorded using the isolated tissue bath system,mechanical tension transducer,and PowerLab physiological *** weighing the stomach,the phenol red labeling method was used to measure the gastric emptying *** LES ultrastructure was observed through transmission electron *** and western blotting were used to detect the number of interstitial cells of Cajal(ICC)and the expression levels of c-kit protein,connexin43(Cx43),and stem cell factor(SCF).Flow cytometric analysis and enzyme-linked immunosorbent assay were conducted to detect the percentages of T helper 17(Th17)cells and regulatory T(Treg)cells and the serum concentrations of interleukin 6(IL-6),interleukin 17(IL-17),and interleukin 10(IL-10)in the ***:We identified 28 chemical constituents in *** esophageal motility,we revealed that HXTJD increased the mean contraction tension forces,mean amplitudes,and mean frequency change rate of LES and the gastric emptying rate;decreased stomach weight;and improved the LES ***,HXTJD increased the number of ICC-positive cells,and c-kit,Cx43,and SCF expression *** esophageal inflammation,HXTJD significantly decreased the percentage of Th17 cells,and IL-6 and IL-17 concentrations,and increased the percentage of Treg cells and IL-10 ***:HXTJD was found to be efficacious in the rat RE *** may promote esophageal motility and alleviate the inflammatory response by activating the SCF/c-kit/ICC

关键词： huoxue tongjiang decoction reflux esophagitis SCF/c-kit/ICC pathway Th17/Treg cell esophageal motility mucosal inflammation

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