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decreased human leukocyte antigen-d-related expression on Cd14^(+)monocytes in patients with out-of-hospital cardiac arrest provided target temperature management therapy:a prospective observational study

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Emergency and Critical Care Medicine 2024年第1期4卷 16-21页

作者： Huan Shao Wei Yuan Ziren Tang Zhijiang Qi Le An Qiang Zhang Chunsheng Li department of Emergency Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina.

Background:Post–cardiac arrest syndrome involves systemic inflammation,which causes subsequent neurological *** investigated the influence of targeted temperature management(TTM)therapy in patients with out-of-hospital cardiac arrest(OHCA)after return of spontaneous circulation(ROSC)by observing the changes in circulating Cd14^(+)monocytes and the expression of human leukocyte antigen d–related(HLA-dR)and programmed cell death ligand 1(Pd-L1)in Cd14^(+)***:Adult patients admitted to the emergency department of Beijing Chao-Yang Hospital after OHCA between January 2017 and March 2018 were included in this *** control subjects,10 patients with OHCA,and 37 patients with OHCA who received 72 hours of TTM therapy were *** blood samples of patients in the OHCA and TTM groups were collected on days 1 and 3(d1 and d3)after ROSC and evaluated for HLA-dR and Pd-L1 expression on Cd14^(+)monocytes using flow ***:Compared with control subjects,the percentage of circulating Cd14^(+)monocytes,HLA-dR+/Cd14^(+)monocyte ratios,and mean fluorescence intensity were significantly decreased in patients with *** ROSC,HLA-dR expression in Cd14^(+)monocytes in the TTM group was lower than that in patients with ***,there were no significant differences in the percentage of Pd-L1+/Cd14^(+)monocytes or the mean fluorescence intensity between patients with OHCA and healthy ***:After ROSC,circulating Cd14^(+)monocytes and HLA-dR+/Cd14^(+)monocyte ratios decreased significantly in patients with *** leukocyte antigen d–related expression in Cd14^(+)monocytes was lower in patients treated with TTM.

关键词： human leukocyte antigen d-related Monocytes Out-of-hospital cardiac arrest Target temperature management

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