Decreased human leukocyte antigen-D-related expression on CD14^(+)monocytes in patients with out-of-hospital cardiac arrest provided target temperature management therapy:a prospective observational study

作     者：Huan Shao Wei Yuan Ziren Tang Zhijiang Qi Le An Qiang Zhang Chunsheng Li Huan Shao;Wei Yuan;Ziren Tang;Zhijiang Qi;Le An;Qiang Zhang;Chunsheng Li

作者机构：Department of Emergency MedicineBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cardiopulmonary Cerebral ResuscitationBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina. 

出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)

年 卷 期：2024年第4卷第1期

页      面：16-21页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(Grant No.81372025) 

主　　题：Human leukocyte antigen D-related Monocytes Out-of-hospital cardiac arrest Target temperature management 

摘      要：Background:Post–cardiac arrest syndrome involves systemic inflammation,which causes subsequent neurological *** investigated the influence of targeted temperature management(TTM)therapy in patients with out-of-hospital cardiac arrest(OHCA)after return of spontaneous circulation(ROSC)by observing the changes in circulating CD14^(+)monocytes and the expression of human leukocyte antigen D–related(HLA-DR)and programmed cell death ligand 1(PD-L1)in CD14^(+)***:Adult patients admitted to the emergency department of Beijing Chao-Yang Hospital after OHCA between January 2017 and March 2018 were included in this *** control subjects,10 patients with OHCA,and 37 patients with OHCA who received 72 hours of TTM therapy were *** blood samples of patients in the OHCA and TTM groups were collected on Days 1 and 3(D1 and D3)after ROSC and evaluated for HLA-DR and PD-L1 expression on CD14^(+)monocytes using flow ***:Compared with control subjects,the percentage of circulating CD14^(+)monocytes,HLA-DR+/CD14^(+)monocyte ratios,and mean fluorescence intensity were significantly decreased in patients with *** ROSC,HLA-DR expression in CD14^(+)monocytes in the TTM group was lower than that in patients with ***,there were no significant differences in the percentage of PD-L1+/CD14^(+)monocytes or the mean fluorescence intensity between patients with OHCA and healthy ***:After ROSC,circulating CD14^(+)monocytes and HLA-DR+/CD14^(+)monocyte ratios decreased significantly in patients with *** leukocyte antigen D–related expression in CD14^(+)monocytes was lower in patients treated with TTM.