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Genetic variation in the chemokine receptor 5 gene and course of HIV infection;review on genetics and immunological aspect

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Genes & Diseases 2021年第4期8卷 475-483页

作者： M.K.Verma S.Shakya Department of Biotechnology Acharya Nagarjuna UniversityNagarjuna NagarGunturAndhra Pradesh522510India Indian Institute of Technology Indore IndoreMadhya Pradesh453552India

Chemokines are small protein molecules associated with various physiological events precisely in immune modulation via dhemokine *** chemokine receptors are G-protein coupled receptors express mainly on the cell surface of immune ***-ruses,including HIV in the early stage of infection,primarily target chemokines receptors and get intemalized easily into immune cells;T cell and escape from immune *** glycoprotein selectively develops an affinity for the extracellular domain of chemokines recep-tors and allows the pathogen to intemalize via ***,CCR-5 remains a crucial signaling pathway that can be translated into the therapeutic target by changing the receptor protein *** populations have a mutation in coding and promoter regions of CCR-5,tun-ing a resistance for HIV ***,there are several mechanisms where the human genome remains in the dynamic state by changing its composition and acquiring ***-gle nucleotide polymorphism is spontaneous phenomenon responsible for precise and point mutation at the *** studies have demonstrated that European and African Amer-ican populations are enriched in significant CCR5 promoter SNP(CCR5432)in the coding and promoter region as ***,such SNP can be an early-stage biomarker in studying HIV and other similar ***,in this study,we have elucidated the role of SNP(both the pro-moter and coding region)and the fate of HIV *** also empathized with the genetics of such SNPs,mostly frequency and its immunological impact.

关键词： Acquired immunodeficiency syndrome Chemokine and chemokine receptors human immune deficiency viruses Single nucleotide polymorphism

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