Genetic variation in the chemokine receptor 5 gene and course of HIV infection;review on genetics and immunological aspect

作     者：M.K.Verma S.Shakya 

作者机构：Department of BiotechnologyAcharya Nagarjuna UniversityNagarjuna NagarGunturAndhra Pradesh522510India Indian Institute of Technology IndoreIndoreMadhya Pradesh453552India 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2021年第8卷第4期

页      面：475-483页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071007[理学-遗传学] 0703[理学-化学] 

基　　金：Department of Biotechnology  Acharya Nagarjuna University 

主　　题：Acquired immunodeficiency syndrome Chemokine and chemokine receptors Human immune deficiency viruses Single nucleotide polymorphism 

摘      要：Chemokines are small protein molecules associated with various physiological events precisely in immune modulation via dhemokine *** chemokine receptors are G-protein coupled receptors express mainly on the cell surface of immune ***-ruses,including HIV in the early stage of infection,primarily target chemokines receptors and get intemalized easily into immune cells;T cell and escape from immune *** glycoprotein selectively develops an affinity for the extracellular domain of chemokines recep-tors and allows the pathogen to intemalize via ***,CCR-5 remains a crucial signaling pathway that can be translated into the therapeutic target by changing the receptor protein *** populations have a mutation in coding and promoter regions of CCR-5,tun-ing a resistance for HIV ***,there are several mechanisms where the human genome remains in the dynamic state by changing its composition and acquiring ***-gle nucleotide polymorphism is spontaneous phenomenon responsible for precise and point mutation at the *** studies have demonstrated that European and African Amer-ican populations are enriched in significant CCR5 promoter SNP(CCR5432)in the coding and promoter region as ***,such SNP can be an early-stage biomarker in studying HIV and other similar ***,in this study,we have elucidated the role of SNP(both the pro-moter and coding region)and the fate of HIV *** also empathized with the genetics of such SNPs,mostly frequency and its immunological impact.