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host defense peptide-mimickingβ-peptide polymer displaying strong antibacterial activity against cariogenic Streptococcus mutans

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Journal of Materials Science & Technology 2023年第2期133卷 77-88页

作者： Yi Yang Yuxin Qian Mingxing Zhang Shuang Hao Hui Wang Yongqiang Fan Runhui Liu Dake Xu Fuhui Wang Life and Health Sciences Northeastern UniversityShenyang 110819China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China Electrobiomaterials Institute Key Laboratory for Anisotropy and Texture of MaterialsMinistry of EducationNortheastern UniversityShenyang 110819China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China School of Environmental and Safety Engineering Liaoning Petrochemical UniversityFushun 113001China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Cariogenic Streptococcus mutans(***)is a leading cause of bacterial-induced oral *** strategies to kill bacteria based on host defense peptide(HDP)mimicking polymers hold promise to treat oral bacterial ***,we explore the impact of hydrophobic subunit and chain length variation on the antibacterial and antibiofilm activity ofβ-peptide *** physicochemical and biological prop-erties,such as the toxicity,the antibacterial activity,and the effect on bacterial transcription ofβ-peptide polymers,were systematically investigated with numerous *** results exhibited that the op-timalβ-peptide polymer has low toxicity towards human periodontal ligament fibroblasts,andβ-peptide polymers(especially P3)have more excellent antibacterial activity against *** than *** addition,β-peptide polymers inhibited the reversible and irreversible bacterial adhesion during the formation of *** polymer can promote biofilm dispersion by decreasing the hydrophobicity of bacterial cells after adhering to cell *** of the transcriptome for *** treated withβ-peptide polymers demonstrated thatβ-peptide polymers could reduce the cariogenicity of *** by impacting the transcription of the energy and acid metabolism-related genes.β-peptide polymers are promising antimicrobial agents in clinical dentistry due to their high antibacterial efficiency and low tox-icity.

关键词： β-peptide polymers host defense peptide S.mutans RT-qPCR Transcriptome

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host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds

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Science China Chemistry 2023年第6期66卷 1824-1833页

作者： Zhongqian Qiao Wenjing Zhang Yueming Wu Weinan Jiang Ning Shao Jiayang Xie Guixue Xia Qimeng Chen Zhefeng Liu Jingcheng Zou Jiawei Gu Shifang Luan Haodong Lin Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound *** hydrogels are widely used to achieve anti-infectious wound ***,due to the quick emergence of drugresistant bacteria,such as methicillin-resistant Staphylococcus aureus(MRSA),wound infection has been a formidable challenge to human *** address MRSA-infected wounds,an antibacterial peptide polymer-loaded hyaluronic acid(HA)hydrogel(Gel-HA@P)is *** peptide polymer is designed to mimic host defense peptides as the antibiotic alternative showing potent antibacterial activity,low susceptibility to drug resistance and good stability against *** is biocompatible and biodegradable hydrogel substrate as a primary constituent of the extracellular matrix and suitable for cell migration and wound ***-HA@P shows potent activity against MRSA in vitro and in vivo,low toxicity during the treatment and promotes the wound healing in *** design has proven to be an effective and antibiotic-free strategy to enable the healing of MRSA-infected wounds.

关键词： peptide polymer wound healing MRSA drug-resistance host defense peptide

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Breaking or following the membrane-targeting mechanism:Exploring the antibacterial mechanism of host defense peptide mimicking poly(2-oxazoline)s

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Journal of Materials Science & Technology 2020年第24期59卷 220-226页

作者： Chengzhi Dai Min Zhou Weinan Jiang Ximian Xiao Jingcheng Zou Yuxin Qian Zihao Cong Zhemin Ji Longqiang Liu Jiayang Xie Zhongqian Qiao Runhui Liu State Key Laboratory of Bioreactor Engineering Frontiers Science Center for Materiobiology and Dynamic ChemistryKey Laboratory of Specially Functional Polymeric Materials and Related Technology(ECUST)Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Molecular Engineering of Polymers(Fudan University) Shanghai200438China

peptides exert important biological functions but their application is hindered by their susceptibility to proteolysis and poor stability in ***,functional peptide mimics have drawn a great deal of attention to address this ***(2-oxazoline)s,a class of biocompatible and proteolysis-resistant polymer,can work as host defense peptide mimics without following the general membrane-targeting mechanism as shown in our previous *** observation encouraged us to figure out if poly(2-oxazoline)s are special and break the general membrane-targeting mechanism of host defense peptides and their *** this study,we aimed at the connection between structure and antibacterial mechanism of poly(2-oxazoline)s.A new γ-aminobutyric acid(GABA)-pendent poly(2-oxazoline)was synthesized and investigated to compare with glycine-pendent poly(2-oxazoline)in our previous study,with the former polymer has two extra CH2 groups in the sidechain to increase the hydrophobicity and *** depolarization assay suggested that incorporating two more CH2 groups into the sidechain of poly(2-oxazoline)resulted in a mechanism switch from DNA-targeting to membrane-targeting,which was supported by the slow time-kill kinetics and slightly distorted and sunken membrane ***,GABA-pendent poly(2-oxazoline)showed potent activity against methicillin-resistant *** and low hemolysis on human red blood ***,repeated use of the antimicrobial poly(2-oxazoline)did not stimulate bacteria to obtain resistance,which was an obvious advantage of membrane-targeting antimicrobial agents.

关键词： Poly(2-oxazoline) host defense peptide Antibacterial mechanism Membrane-targeting Antimicrobial resistance

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Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

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Bioactive Materials 2021年第12期6卷 4531-4541页

作者： Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu State Key Laboratory of Bioreactor Engineering College of ChemistryChemical Engineering and Materials ScienceEast China University of Science and TechnologyShanghai200237China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application Soochow UniversitySuzhou215123China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical *** defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant *** recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide *** we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide *** peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in ***,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and *** vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU *** further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial *** results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices.

关键词： peptide polymer host defense peptide Antimicrobial surface MRSA Subcutaneous infection

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Spider antiviral peptide targets NS2B-NS3 protease of Flaviviruses

Spider antiviral peptide targets NS2B-NS3 protease of Flaviv...

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第十四届生物毒素毒理学术大会暨第一届生物毒素——从生存...

作者： Mengyao Ji Meichen Xing Ren Lai College of Life Sciences Nanjing Agricultural University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences Key Laboratory of Bioactive peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences

Flaviviruses,such as Dengue,Japanese encephalitis,Tick-borne encephalitis,West Nile,Yellow Fever,and Zika virus,are single-stranded RNA viruses and predominantly transmitted by the widely distributed Aedes mosquitoes in *** important human pathogens,the geographic reach of Flaviviruses is increasing and they have become threats to public health worldwide and currently there is no approved specific drug for *** vaccination is the primary strategy for preventing Flaviviruses infections,antivirals may also play an important role in controlling their infection and *** recent years,development of peptide antivirals has gained much *** animal host defense peptides（HDPs） which uniquely evolved to protect the hosts have been shown to have antiviral *** this study,we collected the spider venom of Alopecosa nagpag spider from the Napa sea area of the Shangri-La,Yunnan *** anti-Dengue serotype-2 virus and anti-Zika virus HDP named GY-36 was identified from the spider ***-36 functions as a NS2 B-NS3 protease inhibitor and its anti-flavivirus activity was verified in U251,A549 and RAW264.7 cells by qPCR,plaque assay,western blot and immunofluorescence ***,GY-36 administration in Ifnar～（-/-） mice inhibited Dengue and Zika virus ***,our findings not only demonstrate that GY-36 might be a candidate for antiviral drug,but also indicated spider HDPs as antiviral precursor molecules.

关键词： Alopecosa nagpag Dengue virus Zika virus host defense peptide antiviral mechanism Flaviviruses

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