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Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy

World Journal of Gastroenterology 2010年第42期16卷 5342-5346页

作者： Hiroaki Nema Mototsugu Kato Department of Internal Medicine Teishinkai HospitalNorth 44East 8Higashi-kuSapporoHokkaido 007-0844Japan Division of Endoscopy Hokkaido University HospitalNorth 14West 5Kita-kuSapporoHokkaido 060-8468Japan

AIM:To compare the therapeutic effects of proton pump inhibitors(PPI) and histamine 2 receptor antagonists(H2RA) on gastroduodenal ulcers under continuous use of low-dose ***:Sixty patients who had a gastroduodenal ulcer on screening endoscopy but required continuous use of low-dose aspirin were randomly assigned to receive PPI(lansoprazole 30 mg,n = 30) or H2RA(famotidine 40 mg or if famotidine had been administered before assignment,ranitidine 300 mg,n = 30).The therapeutic effects were evaluated by endoscopy after 8-wk *** presence or absence of Helicobacter pylori(***) was determined by urea breath test before *** symptoms were compared with the gastrointestinal symptom rating scale(GSRS) questionnaire before and after ***:Twenty-six patients in the PPI group and 26 patients in the H2RA group,excluding dropouts,were *** were no significant differences in median age,sex,underlying disease,smoking status,*** infection,prevalence of ulcers before treatment,and lesion site between the two *** therapeutic effects were endoscopically evaluated as healed in 23 patients(88.5%) and not healed in 3 patients in the PPI group and as healed in 22 patients(84.6%) and not healed in 4 patients in the H2RA *** symptoms before treatment were uncommon in both groups;the GSRS scores were not significantly reduced after treatment as compared with before ***:The healing rate of gastroduodenal ulcers during continuous use of low-dose aspirin was greater than 80% in both the PPI group and the H2RA group,with no significant difference between the two groups.

关键词： Low-dose aspirin Proton pump inhibitors histamine 2 receptor antagonists Gastric ulcer

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Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis

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World Journal of Gastroenterology 2014年第25期20卷 8187-8194页

作者： Ji Eun Kwon Seong-Joon Koh Jaeyoung Chun Ji Won Kim Byeong Gwan Kim Kook Lae Lee Jong Pil Im Joo Sung Kim Hyun Chae Jung Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University Boramae HospitalSeoul 156-707South Korea

AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) ***: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric ***: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD ***: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.

关键词： Proton pump inhibitors histamine 2 receptor antagonists Gastrointestinal motility Peritoneal dialysis Peritonitis

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