Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy

作     者：Hiroaki Nema Mototsugu Kato 

作者机构：Department of Internal MedicineTeishinkai HospitalNorth 44East 8Higashi-kuSapporoHokkaido 007-0844Japan Division of EndoscopyHokkaido University HospitalNorth 14West 5Kita-kuSapporoHokkaido 060-8468Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第42期

页      面：5342-5346页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Low-dose aspirin Proton pump inhibitors Histamine 2 receptor antagonists Gastric ulcer 

摘      要：AIM:To compare the therapeutic effects of proton pump inhibitors(PPI) and histamine 2 receptor antagonists(H2RA) on gastroduodenal ulcers under continuous use of low-dose ***:Sixty patients who had a gastroduodenal ulcer on screening endoscopy but required continuous use of low-dose aspirin were randomly assigned to receive PPI(lansoprazole 30 mg,n = 30) or H2RA(famotidine 40 mg or if famotidine had been administered before assignment,ranitidine 300 mg,n = 30).The therapeutic effects were evaluated by endoscopy after 8-wk *** presence or absence of Helicobacter pylori(***) was determined by urea breath test before *** symptoms were compared with the gastrointestinal symptom rating scale(GSRS) questionnaire before and after ***:Twenty-six patients in the PPI group and 26 patients in the H2RA group,excluding dropouts,were *** were no significant differences in median age,sex,underlying disease,smoking status,*** infection,prevalence of ulcers before treatment,and lesion site between the two *** therapeutic effects were endoscopically evaluated as healed in 23 patients(88.5%) and not healed in 3 patients in the PPI group and as healed in 22 patients(84.6%) and not healed in 4 patients in the H2RA *** symptoms before treatment were uncommon in both groups;the GSRS scores were not significantly reduced after treatment as compared with before ***:The healing rate of gastroduodenal ulcers during continuous use of low-dose aspirin was greater than 80% in both the PPI group and the H2RA group,with no significant difference between the two groups.