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Chinese Physics Letters 2014年第3期31卷 91-95页

作者： YU Jie CHEN Chu-Yi CHEN Gong GUO Xia-Sheng MA Yong TU Juan ZHANG Dong Key Laboratory of Modern Acoustics School of Physics Nanjing University Nanjing 210093 Traditional Chinese Medicine Hospital of Jiangsu Province Nanjing 210023 State Key Laboratory of Acoustics Chinese Academy of Sciences Beijing 100190

A software-based method is proposed to eliminate the flooding interference strips in B-mode images, and to evaluate the cavitation bubbles generated during high intensity focused ultrasound （HIFU） exposures. In vitro tissue phantoms are exposed to 1.12 MHz HIFU pulses with a fixed 100 Hz pulse repetition frequency. HIFU-induced cavitation bubbles are detected as hyperechoic regions in B-mode images. The temporal evolution of cavitation bubbles, generated by HIFU pulses with varying driving amplitude and pulse length, is analyzed by measuring the time-varying area of the hyperechoic region. The results show that： first, it is feasible to monitor HIFU-induced cavitation bubble activity in real-time using B-mode imaging; second, more cavitation bubbles can be generated with higher acoustic energy delivered; third, the hyperechoic region is observed to shrink gradually after ceasing the HIFU pulses, which indicates the dissolution of cavitation bubbles. This work will be helpful for developing an effective tool to realize real-time monitoring and quantitative evaluation of HIFU-induced cavitation bubble activity using a current commercialized B-mode machine.

关键词： CAVITATION RESEARCH high-intensity focused ultrasound IMAGING systems QUANTITATIVE research PHYSICS research

Effect of Tissue Inhomogeneity on Nonlinear Propagation of focused ultrasound

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Chinese Physics Letters 2010年第9期27卷 127-130页

作者：刘振波范庭波郭霞生章东 Institute of Acoustics Key Laboratory of Modern Acoustics (Ministry of Education) Nanjing University Nanjing 210093 Nanjing Normal University Nanjing 210097

We study the influence of tissue inhomogeneity on the focused ultrasound based on the phase screen model and the acoustic nonlinear equation. The inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Six polyethylene （PE） plates with various correlation lengths and standard deviations are made to mimic the inhomogeneity induced by the human body abdominal. Results indicate that the correlation length affects the side lobe structure of the beam pattern; while the standard deviation is associated with the focusing capability. This study provides a theoretical and experimental basis for the development of a precise treatment plan for high intensity focused ultrasound.

关键词： INHOMOGENEOUS materials NONLINEAR theories high-intensity focused ultrasound POLYETHYLENE COMBINATIONS (Mathematics) TISSUE engineering

In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

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Chinese Physics B 2012年第7期21卷 352-358页

作者：崔炜程屠娟 Hwang Joo-Ha 李倩范庭波章东陈静海陈伟中 Key Laboratory of Modern Acoustics MOEand Institute of AcousticsNanjing University Center for Industrial and Medical ultrasound Applied Physics LaboratoryUniversity of Washington Department of Cardiology of Children's Hospital Boston Harvard Medical School

Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that：（1） with constant pulse repetition frequency （PRF）（e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.

关键词： hyperthermia effects high-intensity focused ultrasound duty ratio ultrasound contrastagents

Perfluorooctyl bromide nanoemulsions holding MnO_(2) nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death

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Acta Pharmaceutica Sinica B 2022年第2期12卷 967-981页

作者： Xinping Kuai Yuefei Zhu Zheng Yuan Shengyu Wang Lin Lin Xiaodan Ye Yiping Lu Yu Luo Zhiqing Pang Daoying Geng Bo Yin Department of Radiology Huashan HospitalFudan UniversityShanghai 200040China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Department of Radiology Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 201800China Department of Radiology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of high Performance Ceramics and Superfine Microstructure School of Chemical Science and EngineeringShanghai 200092China

Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated ***,existing platforms suffer from low efficacy,inability to induce strong immunogenic cell death(ICD),and restrained capacity of transforming immune-deserted tumors into immune-cultivated ***,an innovative platform,perfluorooctyl bromide(PFOB)nanoemulsions holding MnO_(2) nanoparticles(MBP),was developed to orchestrate cancer immunotherapy,serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced *** simultaneously depleting the GSH and eliciting the ICD effect via highintensity focused ultrasound(HIFU)therapy,the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells(DCs)and facilitating the activation of CD8^(+)and CD4^(+)T *** synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung ***,these findings inaugurate a new strategy of tumor-targeted immunotherapy,realizing a novel therapeutics paradigm with great clinical significance.

关键词： Immunogenic cell death Nanoemulsions Manganese dioxide nanoparticles Glutathione depletion Dual-modality imaging high-intensity focused ultrasound Tumor microenvironment

Locoregional therapies and their effects on the tumoral microenvironment of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1288-1303页

作者： Thomas Lambin Cyril Lafon Robert Andrew Drainville Mathieu Pioche Frédéric Prat LabTAU INSERMCentre Léon BérardUniversitéLyon 1Univ LyonLyon 69003France Department of Gastroenterology Hospices Civils de LyonEdouard Herriot HospitalLyon 69008France Service d’Endoscopie Digestive Hôpital BeaujonAssistance Publique-Hôpitaux de ParisClichy 92110France INSERM U1016 Institut CochinUniversitéde ParisParis 75014France

Pancreatic ductal adenocarcinoma(PDAC) is expected to become the second leading cause of death from cancer by 2030. Despite intensive research in the field of therapeutics, the 5-year overall survival is approximately 8%, with only 20% of patients eligible for surgery at the time of diagnosis. The tumoral microenvironment(TME) of the PDAC is one of the main causes for resistance to antitumoral treatments due to the presence of tumor vasculature, stroma, and a modified immune response. The TME of PDAC is characterized by high stiffness due to fibrosis, with hypo microvascular perfusion, along with an immunosuppressive environment that constitutes a barrier to effective antitumoral treatment. While systemic therapies often produce severe side effects that can alter patients’ quality of life, locoregional therapies have gained attention since their action is localized to the pancreas and can thus alleviate some of the barriers to effective antitumoral treatment due to their physical effects. Local hyperthermia using radiofrequency ablation and radiation therapy-most commonly using a local high single dose-are the two main modalities holding promise for clinical efficacy. Recently, irreversible electroporation and focused ultrasound-derived cavitation have gained increasing attention. To date, most of the data are limited to preclinical studies, but ongoing clinical trials may help better define the role of these locoregional therapies in the management of PDAC patients.

关键词： Pancreatic ductal adenocarcinoma Tumoral microenvironment Stroma Hyperthermia Radiation therapy high-intensity focused ultrasound

New frontiers in focal therapy for prostate cancer:Prostate-specific membrane antigen positron emission tomography/magnetic resonance imaging

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World Journal of Clinical Oncology 2021年第2期12卷 61-68页

作者： Celeste Manfredi Esau Fernandez-Pascual Estefanía Linares-Espinós Felipe Couñago Juan Ignacio Martínez-Salamanca Department of Woman Child and General and Specialized SurgeryUrology UnitUniversity of Campania“Luigi Vanvitelli”Naples 81110Italy Department of Urology Hospital Universitario La PazMadrid 28046Spain LYX Institute of Urology Facultad de MedicinaUniversidad Francisco de VitoriaPozuelo de Alarcón 28223MadridSpain Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Urology Hospital Universitario Puerta Hierro-MajadahondaMajadahonda 28222MadridSpain

Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of *** papers reported the potential advantages of PSMA PET/MRI in different clinical *** evidence on PSMA PET/MRI is available in the setting of *** PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary *** PET/MRI also shows high performance for restaging and detecting tumor *** higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed *** PET/MRI could represent a turning point in the management of patients with PCa in the context of *** studies are needed to confirm its applications in this specific clinical setting.

关键词： Prostate-specific membrane antigen Positron emission tomography/magnetic resonance imaging Prostate cancer Focal therapy high-intensity focused ultrasound Cryotherapy

DUAL-FOCUS SCANNING IN VOLUMETRIC HIFU ABLATION:PRELIMINARY SIMULATION STUDY

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DUAL-FOCUS SCANNING IN VOLUMETRIC HIFU ABLATION:PRELIMINARY ...

高强度聚焦超声结合超声引导下瘤内无水乙醇注射治疗子宫肌瘤的对照研究

2015全国压电和声波理论及器件技术研讨会

作者： Ke LI Jing-feng BAI Ya-zhu CHEN Xiang JI School of Biomedical Engineering Shanghai Jiao Tong University

Volumetric HIFU ablation has been implemented in clinical practice to create large thermal lesion while reducing treatment ***,it still takes several hours to cover the whole target using volumetric *** focus intensity patterns have been proved beneficial to create larger *** feasibility of dual-focus scanning in volumetric ablation has been *** of dual-focus scanning and single-focus scanning were performed with the treatment cells of 4,8,12 and 16 mm in *** of both scanning approaches indicates that the dual-focus scanning saves treatment time by 20%and needs lower peak acoustic pressure,therefore the potential cavitation could be *** the maximum near-field temperatures are slightly higher than single-focus scanning,they are acceptable in HIFU treatment.

关键词： Dual-focus scanning Volumetric ablation high-intensity focused ultrasound Treatment time

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高强度聚焦超声结合超声引导下瘤内无水乙醇注射治疗子宫肌瘤的对...