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Extrahepatic bile duct reconstruction in pigs with heterogenous animal-derived artificial bile ducts:A preliminary experience

引用

World Journal of Gastroenterology 2020年第46期26卷 7312-7324页

作者： Hao Shang Jian-Ping Zeng Si-Yuan Wang Ying Xiao Jiang-Hui Yang Shao-Qing Yu Xiang-Chen Liu Nan Jiang Xia-Li Shi Shuo Jin Department of Hepatopancreatobiliary Surgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102200China Department of Pathology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102200China Institute for Precision Medicine Tsinghua University Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Anesthesiology and Operation The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Extrahepatic biliary duct injury(BDI)remains a complicated issue for *** several approaches have been explored to address this problem,the high incidence of complications affects postoperative *** a nonimmunogenic scaffold,an animal-derived artificial bile duct(ada-BD)could replace the defect,providing good physiological conditions for the regeneration of autologous bile duct structures without changing the original anatomical and physiologic *** To evaluate the long-term feasibility of a novel heterogenous ada-BD for treating extrahepatic BDI in *** Eight pigs were randomly divided into two groups in the *** animal injury model was developed with an approximately 2 cm segmental defect of various parts of the common bile duct(CBD)for all pigs.A 2 cm long novel heterogenous animal-derived bile duct was used to repair this segmental defect(group A,ada-BD-to-duodenum anastomosis to repair the distal CBD defect;group B,ada-BD-to-CBD anastomosis to repair the intermedial CBD defect).The endpoint for observation was 6 mo(group A)and 12 mo(group B)after the *** function was regularly *** were euthanized at the above *** analysis was carried out to assess the efficacy of the *** The median operative time was 2.45 h(2-3 h),with a median anastomosis time of 60.5 min(55-73 min).All experimental animals survived until the endpoints for *** liver function was almost *** analysis indicated a marked biliary epithelial layer covering the neo-bile duct and regeneration of the submucosal connective tissue and smooth muscle without significant signs of immune *** comparison,the submucosal connective tissue was more regular and thicker in group B than in group A,and there was superior integrity of the regeneration of the biliary epithelial *** the advantages of the regeneration of the bile duct smooth muscle observed in group A,th

关键词： Bile duct injury Animal-derived artificial bile duct heterogenous ureteral graft Nonimmunogenic Bile duct reconstruction Common bile duct

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