检索结果-南通市图书馆

Virus genomes and virus-host interactions in aquaculture animals

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2015年第2期58卷 156-169页

作者： ZHANG QiYa GUI Jian-Fang State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences University of the Chinese Academy of Sciences

Over the last 30 years,aquaculture has become the fastest growing form of agriculture production in the world,but its development has been hampered by a diverse range of pathogenic *** the last decade,a large number of viruses from aquatic animals have been identified,and more than 100 viral genomes have been sequenced and genetically *** advances are leading to better understanding about antiviral mechanisms and the types of interaction occurring between aquatic viruses and their ***,based on our research experience of more than 20 years,we review the wealth of genetic and genomic information from studies on a diverse range of aquatic viruses,including iridoviruses,herpesviruses,reoviruses,and rhabdoviruses,and outline some major advances in our understanding of virus–host interactions in animals used in aquaculture.

关键词： aquaculture viral genome antiviral defense iridoviruses reoviruses rhabdoviruses herpesviruses host-virusinteractions

Remodeling of host membranes during herpesvirus assembly and egress

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2019年第5期10卷 315-326页

作者： Ying Lv Sheng Zhou Shengyan Gao Hongyu Deng CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Many viruses,enveloped or non-enveloped,remodel host membrane structures for their replication,assembly and escape from host *** are important human pathogens and cause many *** large enveloped DNA viruses,herpesviruses undergo several complex steps to complete their life cycles and produce infectious ***,herpesvirus assembly initiates in the nucleus,producing nucleocapsids that are too large to cross through the nuclear *** nucleocapsids instead bud at the inner nuclear membrane to form primary enveloped virions in the perinuclear space followed by fusion of the primary envelopes with the outer nuclear membrane,to translocate the nucleocapsids into the ***,nucleocapsids obtain a series of tegument proteins in the cytoplasm and bud into vesicles derived from host organelles to acquire viral *** vesicles are then transported to and fuse with the plasma membrane to release the mature virions to the extracellular ***,at least two budding and fusion events take place at cellular membrane structures during herpesviruses assembly and egress,which induce membrane *** this review,we describe and discuss how herpesviruses exploit and remodel host membrane structures to assemble and escape from the host cell.

关键词： herpesviruses assembly egress budding fusion membrane deformations

Extracellular vesicles： novel vehicles in herpesvirus infection

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2017年第5期32卷 349-356页

作者： Lingzhi Liu Quan Zhou Yan Xie Lielian Zuo Fanxiu Zhu Jianhong Lu The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health Xiangya Hospital Central South University Changsha 410080 China Cancer Research Institute Central South University Changsha 410078 China Faculty of Chemical Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 China Department of Microbiology School of Basic Medical Science Central South University Changsha410078 China Department of Biological Science Florida State University Tallahassee 32306 USA

herpesviruses are remarkable pathogens that have evolved multiple mechanisms to evade host immunity, ensuring their proliferation and egress. Among these mechanisms, herpesviruses utilize elaborate extracellular vesicles, including exosomes, for the intricate interplay between infected host and recipient cells. herpesviruses incorporate genome expression products and direct cellular products into exosomal cargoes. These components alter the content and function of exosomes released from donor cells, thus affecting the downstream signalings of recipient cells. In this way, herpesviruses hijack exosomal pathways to ensure their survival and persistence, and exosomes are emerging as critical mediators for virus infection-associated intercellular communication and microenvironment alteration. In this review, the function and effects of exosomes in herpesvirus infection will be discussed, so that we will have a better understanding about the pathogenesis of herpesviruses.

关键词： herpesviruses extracellular vesicles(EVs) infection pathogenesis

Herpesviral infection and Toll-like receptor 2

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2012年第8期3卷 590-601页

作者： Ming-sheng Cai Mei-li Li Chun-fu Zheng State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Department of Veterinary Medicine Foshan Science and Technology UniversityFoshan 528231China Department of Pathogenic Biology and Immunology Guangzhou Medical UniversityGuangzhou 510182China

In the last decade,substantial progress has been made in understanding the molecular mechanisms involved in the initial host responses to viral ***-viral infections can provoke an inflammatory cytokine response,however,the innate pathogen-sensing mechanisms that transduce the signal for this response are poorly *** recent years,it has become increasingly evident that the Toll-like receptors(TLRs),which are germline-encoded pattern recognition re-ceptors(PRRs),function as potent sensors for *** can induce the activation of the innate immunity by recruiting specific intracellular adaptor proteins to initiate signaling pathways,which then culminating in activation of the nuclear factor kappa B(NF-κB)and interferon-regulatory factors(IRFs)that control the transcription of genes encoding type I interferon(IFN I)and other inflammatory ***,activa-tion of innate immunity is critical for mounting adaptive immune *** parallel,common mechanisms used by viruses to counteract TLR-mediated responses or to actively subvert these pathways that block recog-nition and signaling through TLRs for their own benefit are *** findings have demonstrated that TLR2 plays a crucial role in initiating the inflammatory process,and surprisingly that the response TLR2 trig-gers might be overzealous in its attempt to counter the attack by the *** this review,we summarize and discuss the recent advances about the specific role of TLR2 in triggering inflammatory responses in herpes-virus infection and the consequences of the alarms raised in the host that they are assigned to protect.

关键词： herpesviruses innate immune Toll-like receptor(TLR) TLR2

The Importance of Heparan Sulfate in Herpesvirus Infection

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2008年第6期23卷 383-393页

作者： Christopher D. O'Donnell Deepak Shukla Department of Microbiology and Immunology College of MedicineUniversity of Illinois at Chicago Department of Ophthalmology and Visual Sciences College of MedicineUniversity of Illinois at Chicago

Herpes simplex virus type-1 (HSV-1) is one of many pathogens that use the cell surface glycosaminoglycan heparan sulfate as a receptor. Heparan sulfate is highly expressed on the surface and extracellular matrix of virtually all cell types making it an ideal receptor. Heparan sulfate interacts with HSV-1 envelope glycoproteins gB and gC during the initial attachment step during HSV-1 entry. In addition,a modified form of heparan sulfate,known as 3-O-sulfated heparan sulfate,interacts with HSV-1 gD to induce fusion between the viral envelope and host cell membrane. The 3-O-sulfation of heparan sulfate is a rare modification which occurs during the biosynthesis of heparan sulfate that is carried out by a family of enzymes known as 3-O-sulfotransferases. Due to its involvement in multiple steps of the infection process,heparan sulfate has been a prime target for the development of agents to inhibit HSV entry. Understanding how heparan sulfate functions during HSV-1 infection may not only be critical for inhibiting infection by this virus,but it may also be crucial in the fight against many other pathogens as well.

关键词： Heparan sulfate (HS) herpesviruses Herpes simplex virus type-1 (HSV-1) 3-O-sulfotransferases Viral entry

Cytomegalovirus immune evasion by perturbation ot endosomal trafficking

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2015年第2期12卷 154-169页

作者： Pero Lucin Hana Mahmutefendic Gordana Blagojevic Zagorac Maja Ilic Tomas Department of Physiology and Immunology University of Rijeka Faculty of Medicine Rijeka Croatia

Cytomegaloviruses （CMVs）, members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection, They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins （major histocompatibility Class I and Class II molecules） from the cell surface that display viral antigens to CD8 and CD4 T lymphocytes, CMVs also successfully escape recognition and elimination of infected cells by natural killer （NK） cells, effector cells of innate immunity, either by mimicking NK cell inhibitory ligands or by downregulating NK cell-activating ligands, To accomplish these immunoevasion functions, CMVs encode several proteins that function in the biosynthetic pathway by inhibiting the assembly and trafficking of cellular proteins that participate in immune recognition and thereby, block their appearance at the cell surface, However, elimination of these proteins from the cell surface can also be achieved by perturbation of their endosomal route and subsequent relocation from the cell surface into intracellular compartments, Namely, the physiological route of every cellular protein, including immune recognition molecules, is characterized by specific features that determine its residence time at the cell surface, In this review, we summarize the current understanding of endocytic trafficking of immune recognition molecules and perturbations of the endosomal system during infection with CMVs and other members of the herpesvirus family that contribute to their immune evasion mechanisms,

关键词： cytomegaloviruses endocytic trafficking herpesviruses immune evasion