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herbal medicines and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第30期22卷 6890-6905页

作者： Hong Yao Yu-Jie Qiao Ya-Li Zhao Xu-Feng Tao Li-Na Xu Lian-Hong Yin Yan Qi Jin-Yong Peng College of Pharmacy Dalian Medical University Dalian 116044 Liaoning Province China

Nonalcoholic fatty liver disease(NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines(including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.

关键词： herbal medicines Nonalcoholic fatty liver disease Natural product Traditional Chinese medicines Review

Analysis on herbal medicines utilized for treatment of COVID-19

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1192-1204页

作者： Lu Luo Jingwen Jiang Cheng Wang Martin Fitzgerald Weifeng Hu Yumei Zhou Hui Zhang Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China West China Biomedical Big Data Center West China HospitalSichuan UniversityChengdu 610041 China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100006China Ashdale Clinic Cork T12 T2VKIreland The Third Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310000China The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou 518033China Akupunktur Akademiet Aabyhoej 8230Denmark

As coronavirus disease 2019(COVID-19)pandemic poses a substantial global public health threat,traditional Chinese medicine(TCM)was used in 91.50%of the COVID-19 cases in China,showing encouraging results in improving symptom management and reducing the deterioration,mortality,and recurrence rates.A total of 166 modified herbal formulae consisting of 179 single herbal medicines were collected for treating COVID-19 in *** Radix et Rhizome,Scutellariae Radix,and Armeniacae Semen Amarum are the most frequently utilized in clinics,most of which are antipyretic(47,26.26%),expectorant and cough-suppressing(22,12.29%),and dampness-resolving(21,11.73%)from traditional descriptions.A total of 1212 chemical components containingβ-sitosterol,stigmasterol,and quercetin were primarily ***,using complex system entropy and unsupervised hierarchical clustering,8 core herbal combinations and 10 new formulae emerged as potentially useful candidates for ***,following scaffold analysis,self-organizing mapping(SOM)and cluster analysis,12 clusters of molecules yielded 8 pharmacophore families of structures that were further screened as pharmacological targets in human metabolic pathways for inhibiting *** article aims to make more easily accessible and share historical herbal knowledge used in contemporary treatments in a modern manner to assist researchers contain the global spread of COVID-19.

关键词： COVID-19 Traditional Chinese medicine(TCM) herbal medicines Clustering analysis Scaffold analysis

Analysis of Chlorogenic Acid in herbal medicines by Capillary Electrophoresis

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Chinese Chemical Letters 1998年第10期9卷 941-944页

作者： Long, H Yang, JJ Liu, HW Wang, TS Huang, AJ Sun, YL Peking Univ Dept Chem Beijing 100871 Peoples R China

A simple, rapid and accurate capillary zone electrophoresis method was developed for the determination of chlorogenic acid as a marker in traditional Chinese medicines. The buffer solution comprised of 10 mmol/L sodium phosphate and 20 mmol/L boric acid containing 5% ethanol with the pH value adjusted to 7.00. The contents of chlorogenic acid in Flos Lonicerae and Flos Lonicerae containing herbal preparations were determined within 15 min.

关键词： chlorogenic acid quantitation herbal medicines capillary zone electrophoresis

Quality Control Approaches for Chinese herbal medicines

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Chinese herbal medicines 2011年第1期3卷 17-22页

作者： YUAN Hai-long1,ZHANG Tian-tian1,2,XIAO Xiao-he1 1.Institute of Chinese Materia Medica,302 Military Hospital,Beijing 100039,China 2.Pharmacy College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China Institute of Chinese Materia Medica 302 Military HospitalBeijing 100039China Institute of Chinese Materia Medica 302 Military HospitalBeijing 100039China Pharmacy College Chengdu University of Traditional Chinese MedicineChengdu 610075China

The current official quality control approaches meet the challenges from the complexity of herbal *** fact,any herbal medicines containing numerous unknown components,its curative effect usually depends on the whole of herbal medicines,so it is impossible and unnecessary to qualitatively and quantitatively study every *** investigating the limitations of current quality control approaches for herbal medicines and the difference and similarity in the chemical substantial style as well as quality control pattern of herbal medicines,a new quality control approach for Chinese herbal medicines should be explored and *** combination approach of chemical analysis with bioassay is promising to be developed and employed in order to ensure the safety and efficacy of Chinese herbal medicines.

关键词： bioassay chemical analysis combination approach herbal medicines quality control

Effects of Traditional Chinese herbal medicines on Blood Ions and Enzymes of Egg-laying Hens Under Heat Stress

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Agricultural Science & Technology 2014年第12期15卷 2171-2174页

作者：高桂生史秋梅沈萍刘欢邢超张雪莲高光平张艳英河北科技师范学院/河北省预防兽医学重点实验室河北昌黎066600

[Objective] This study was conducted to investigate the effects of tradi- tional Chinese herbal medicines on blood biochemical indices of egg-laying hens under heat stress and to provide theoretical basis for clinical application of the medicines. [Method] One hundred of 88-day-old ISA-Brown hens were randomly di- vided into five groups. The hens in four groups were administrated with Prescription I herbal medicines, Prescription II herbal medicines, Vc and blank control under ar- tificially simulated heat stress, respectively. The last group was raised under normal temperature condition. Blood samples of the hens were collected on 1, 4, 8 and 10 d later and detected for their biochemical indices. [Result] The blood sodium （Na）, phosphorus （P）, potassium （K） and chlorine （CI） concentrations in hens under heat stress were decreased, while the activities of alanine aminotransferase （ALT）, lactate dehydrogenase （LDH） and creatine kinase （CK） were increased. These indices grad- ually returned to normal levels after the use of traditional Chinese herbal medicines. [Conclusion] The herbal medicines can relieve the adverse effects caused by heat stress to blood biochemical indices via different metabolic pathways of ions and en- zymes.

关键词： Heat stress Egg-laying hens herbal medicines Blood biochemical in- dices

Integration of Gut Microbiota and Metabolomics for Chinese Medicine Research:Opportunities and Challenges

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Chinese Journal of Integrative Medicine 2022年第11期28卷 1032-1039页

作者： FENG Wu-wen LIU Juan CHENG Hao PENG Cheng School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(611137)China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengdu(611137)China

Chinese medicines(CM)are gaining more attentions from all over the ***,there are a large body of questions to be answered because of the chemical complexity of CM and intricate molecular reactions within human *** recent years,gut microbiota and metabolomics have emerged as two cynosures in deciphering the mechanisms of how our body is *** gut microbiota and host is a closely interrelated system,paying attention only to gut microbiota or metabolites may omit the interplays among CM,gut microbiota,and *** systemically study these interplays,a network understanding of CM components,gut microbiota,metabolites of gut microbiota,metabolites in human body is *** there are some obstacles impeding the application of this integrative approach,the potential areas for implementation of the integrative approach is *** areas include,but not limited to,elucidating the mechanisms of CM at system level,screening bioactive compounds in CM,and guiding quality control of CM.

关键词： gut microbiota metabolomics Chinese medicine herbal medicines

Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 69-77页

作者： Aishah E.Albalawi Norah A.Althobaiti Reem Hasaballah Alhasani Sultan F.Alnomasy Faculty of Science Department of BiologyUniversity of TabukTabuk 47913Saudi Arabia Biology Department College of Science and HumanitiesAl QuwaiiyahShaqra UniversityAl Quwaiiyah 19257Saudi Arabia Department of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMakkahSaudi Arabia Department of Medical Laboratories Sciences College of Applied Medical SciencesAl-QuwayiyahShaqra UniversityRiyadhSaudi Arabia

Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in ***:Swiss albino mice(n=40)were divided into five groups:normal control mice,mice with Ehrlich solid tumors treated with normal saline,mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d,or 50mg/kg or 100 mg/kg PAME orally once a day for 14 *** growth inhibition,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers,antioxidant enzymes,tumor necrosis factor-alpha level(TNF-α),and apoptosis-regulatory gene expression were ***:Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers and TNF-αlevel in comparison with mice with Ehrlich solid tumors receiving normal *** PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes(P<0.05).Conclusions:Pistacia atlantica methanolic extract has potent antitumor activity in ***,the extract might be considered as an alternative anticancer agent against tumors,however,additional studies especially in the clinical setting are required to confirm this finding.

关键词： Cancer Ehrlich solid tumors Treatment Pistacia atlantica herbal medicines Natural product in vivo Mice

Antibacterial and anti-parasitic activities of Terfezia claveryi methanolic extract against some common pathogenic agents of infectious diarrhea

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Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 216-222页

作者： Sultan F Alnomasy Department of Medical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antidiarrheal effects of Terfezia claveryi methanolic extract against Escherichia coli,Salmonella typhimurium,Shigella flexneri,and Giardia ***:Antibacterial effects of the Terfezia claveryi methanolic extract were carried out by determining the minimum inhibitory concentration(MIC)and minimum bactericidal concentration through micro broth dilution ***,reactive oxygen species production and protein leakage were *** evaluate the in vitro anti-giardial effects of Terfezia claveryi methanolic extract,Giardia lamblia WB(ATCC®30957)trophozoites were treated with various concentrations of Terfezia claveryi methanolic extract for 10-360 *** addition,the plasma membrane permeability of trophozoites treated with Terfezia claveryi methanolic extract was *** cytotoxicity effects of Terfezia claveryi methanolic extract against normal(HEK293T)and cancer(MCF-7)cells were also assessed using the MTT ***:The MIC and minimum bactericidal concentration of Terfezia claveryi methanolic extract against bacterial strains were in the range of 0.52-1.04 and 1.04-2.08 mg/mL,*** results revealed that reactive oxygen species production and protein leakage were significantly increased after the bacteria were treated with the Terfezia claveryi methanolic extract,especially at 1/3 and 1/2 MICs(P<0.001).Furthermore,Terfezia claveryi methanolic extract decreased the viability of Giardia lamblia trophozoites in a dose-dependent *** claveryi methanolic extract at 1,2,and 4 mg/mL resulted in 100%mortality in Giardia lamblia trophozoites after 360,240,and 120 min,***,Terfezia claveryi methanolic extract altered the permeability of plasma membrane of Giardia lamblia trophozoites by increasing the *** assay revealed that the 50%cytotoxic concentrations values for HEK293T and MCF-7 cells were 4.32 mg/mL and 6.40 mg/mL,respectively,indicating that Terfezia clavery

关键词： Terfezia claveryi Shigellosis Giardiasis herbal medicines Infectious diarrhea Cellular mechanisms Cytotoxicity Microbiology

Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami Hamid Reza Mohammadi Hossein Mahmoudvand Mohammad Nabi Moradi Javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi herbal medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation