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Statin-induced liver injury Patterns: A Clinical Review

Journal of Clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： Leon D.Averbukh Alla Turshudzhyan David C.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-CoA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf Causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： Drug-induced liver injury Statin Cholestatic liver injury hepatocellular liver injury Cholestasis Autoimmune hepatitis

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