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Roles of ribosomal proteins in hematologic disorders and cancers:a review

Emergency and Critical Care Medicine 2023年第1期3卷 23-31页

作者： Jie Wang Feng Yan Shandong Key Laboratory of Cardiovascular Proteomics Department of Geriatric MedicineQilu Hospital of Shandong UniversityJinanChina Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanChina

Ribosomes are important organelles for synthesizing proteins in cells.They are composed of ribosomal RNA and more than 80 ribosomal proteins.It is well known that an essential function of ribosomal proteins is to participate in protein translation.In addition,ribosomal proteins also perform extra-ribosomal functions,such as participating in DNA replication,transcription,and damage repair,regulating cell growth,proliferation,apoptosis,and transformation.In recent years,studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases,including Diamond-Blackfan anemia,5q-syndrome,Shwachman-Diamond syndrome,and other blood system diseases.Moreover,abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors.In this review,we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal,prostate,gastric,esophageal,and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers.

关键词： Cancers Extra-ribosomal function hematologic diseases Ribosomal protein Ribosome

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Post-hematopoietic stem cell transplantation in patients with hematologic disorders:Chinese herbal medicine for an unmet need

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Journal of Integrative Medicine 2016年第5期14卷 322-335页

作者： Tom Fleischer Tung-Ti Chang Hung-Rong Yen Graduate Institute of Chinese Medicine College of Chinese Medicine China Medical University Department of Chinese Medicine China Medical University Hospital School of Chinese Medicine China Medical University School of Post-baccalaureate Chinese Medicine China Medical University Research Center for Chinese Medicine & Acupuncture China Medical University Research Center for Traditional Chinese Medicine Department of Medical Research China Medical University Hospital

While much progress has been made in the field of hematopoietic stem cell transplantation （HSCT）, headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine （CHM） for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention. Of the 9 papers, 6 were published by the same group of researchers. The focus of the reviewed studies was heterogeneous, and the objectives varied widely. With the exception of one randomized control trial, all of the studies were retrospective and observational; the median number of patients was 11.5, with the largest study containing 104 patients. CHM treatment was largely divided into two stages：（1） pre-HSCT, which was initiated as soon as conditioning chemotherapy was administered and aimed to counterbalance the adverse effects of these potent agents; （2） post-HSCT, which began immediately after transplantation and was intended to promote engraftment, control graft- versus-host disease and prolong survival. In addition, the 9 Chinese materia medica most commonly prescribed （appearing in four studies） were： Shengdihuang （Rehmannia glutinosa）, Baizhu （Atractylodes macrocephala）, Renshen （Panax ginseng）, Dangshen （ Codonopsis pilosula）, Maimendong （ Ophiopogon japonicus）, Danggui （Angelica sinensis）, Taizishen （Pseudostellaria heterophylla）, Huangqi （Astragalus membranaceus） and Ejiao （Equus asinus）.

关键词： hematologic diseases hematologic disorder hematopoietic stem cells Chinese herbalmedicine hematopoietic stem cell transplantation review

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Application and Assessment of Chinese Arsenic Drugs in Treating Malignant Hematopathy in China

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Chinese Journal of Integrative Medicine 2010年第4期16卷 368-377页

作者：胡晓梅刘锋麻柔 Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical Sciences

Chinese arsenic drugs have been applied in Chinese medicine for several centuries. Beginning from 1970s, arsenic containing drugs have been generally used for the treatment of malignant hematologic diseases including acute promyelocytic leukemia, myelodysplastic syndrome, and multiple myeloma. No matter what ingredients of arsenic drugs were applied, either arsenic trioxide, arsenic disulfide, or arsenic containing Chinese herbal compositions including Qinghuang Powder （青黄散） and Realgar-lndigo naturalis formula （复方黄黛片）, they all provided the distinct approaches for the management of malignant hematologic diseases, and good clinical efficacy was obtained with mild adverse reactions. Moreover, the mechanisms of action have been continuallv elucidated.

关键词： Chinese drug arsenic hematologic diseases clinical efficacy mechanism adverse reaction

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Atlas of clinical hematology /

Atlas of clinical hematology /

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2002年

作者： Douglas C. Tkachuk J. V. Hirschmann James R. McArthur.

来源：畅想之星图书光盘版（南... 评论

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