Roles of ribosomal proteins in hematologic disorders and cancers:a review

作     者：Jie Wang Feng Yan Jie Wang;Feng Yan

作者机构：Shandong Key Laboratory of Cardiovascular ProteomicsDepartment of Geriatric MedicineQilu Hospital of Shandong UniversityJinanChina Department of Emergency MedicineQilu Hospital of Shandong UniversityJinanChina 

出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)

年 卷 期：2023年第3卷第1期

页      面：23-31页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(81601721) the Natural Science Foundation of Shandong Province(ZR2016HB11). 

主　　题：Cancers Extra-ribosomal function Hematologic diseases Ribosomal protein Ribosome 

摘      要：Ribosomes are important organelles for synthesizing proteins in cells.They are composed of ribosomal RNA and more than 80 ribosomal proteins.It is well known that an essential function of ribosomal proteins is to participate in protein translation.In addition,ribosomal proteins also perform extra-ribosomal functions,such as participating in DNA replication,transcription,and damage repair,regulating cell growth,proliferation,apoptosis,and transformation.In recent years,studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases,including Diamond-Blackfan anemia,5q-syndrome,Shwachman-Diamond syndrome,and other blood system diseases.Moreover,abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors.In this review,we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal,prostate,gastric,esophageal,and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers.